Search Results - "Kerschen, Edward J"

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C by Kerschen, Edward J, Fernandez, José A, Cooley, Brian C, Yang, Xia V, Sood, Rashmi, Mosnier, Laurent O, Castellino, Francis J, Mackman, Nigel, Griffin, John H, Weiler, Hartmut

“…Activated protein C (APC) reduces mortality of severe sepsis patients but increases the risk of serious bleeding. APC exerts anticoagulant activity by…”
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Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity by Geiger, Hartmut, Pawar, Snehalata A, Kerschen, Edward J, Nattamai, Kalpana J, Hernandez, Irene, Liang, Hai Po H, Fernández, Jose Á, Cancelas, Jose A, Ryan, Marnie A, Kustikova, Olga, Schambach, Axel, Fu, Qiang, Wang, Junru, Fink, Louis M, Petersen, Karl-Uwe, Zhou, Daohong, Griffin, John H, Baum, Christopher, Weiler, Hartmut, Hauer-Jensen, Martin

“…Using an unbiased genetic screen in mice, Hartmut Geiger et al . found that the thrombomodulin–activated protein C pathway, which controls blood coagulation…”
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BOUNDARY-LAYER RECEPTIVITY TO FREESTREAM DISTURBANCES by Saric, William S, Reed, Helen L, Kerschen, Edward J

“…The current understanding of boundary-layer receptivity to external acoustic and vortical disturbances is reviewed. Recent advances in theoretical modeling,…”
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Gr1⁺ Cells Control Growth of YopM-Negative Yersinia pestis during Systemic Plague by Ye, Zhan, Kerschen, Edward J, Cohen, Donald A, Kaplan, Alan M, van Rooijen, Nico, Straley, Susan C

“…YopM, a protein toxin of Yersinia pestis, is necessary for virulence in a mouse model of systemic plague. We previously reported YopM-dependent natural killer…”
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The Plague Virulence Protein YopM Targets the Innate Immune Response by Causing a Global Depletion of NK Cells by KERSCHEN, Edward J, COHEN, Donald A, KAPLAN, Alan M, STRALEY, Susan C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers by Sood, Rashmi, Zogg, Mark, Westrick, Randal J, Guo, Yi-He, Kerschen, Edward J, Girardi, Guillermina, Salmon, Jane E, Coughlin, Shaun R, Weiler, Hartmut

“…We describe a mouse model of fetal loss in factor V Leiden (FvL) mothers in which fetal loss is triggered when the maternal prothrombotic state coincides with…”
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Antibody against V Antigen Prevents Yop-Dependent Growth of Yersinia pestis by Philipovskiy, Alexander V, Cowan, Clarissa, Wulff-Strobel, Christine R, Burnett, Sandra H, Kerschen, Edward J, Cohen, Donald A, Kaplan, Alan M, Straley, Susan C

“…The V antigen (LcrV) of the plague bacterium Yersinia pestis is a potent protective antigen that is under development as a vaccine component for humans. LcrV…”
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EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice by Liang, Hai Po H., Kerschen, Edward J., Hernandez, Irene, Basu, Sreemanti, Zogg, Mark, Botros, Fady, Jia, Shuang, Hessner, Martin J., Griffin, John H., Ruf, Wolfram, Weiler, Hartmut

“…Infection and inflammation are invariably associated with activation of the blood coagulation mechanism, secondary to the inflammation-induced expression of…”
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Mice Naturally Resistant to Yersinia pestis Δpgm Strains Commonly Used in Pathogenicity Studies by Congleton, Yasemin H.K, Wulff, Christine R, Kerschen, Edward J, Straley, Susan C

“…We report that females of some substrains of inbred mouse strain 129 are resistant to systemic plague due to conditionally virulent Δpgm strains of Yersinia…”
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Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice by Liang, Hai Po H., Kerschen, Edward J., Basu, Sreemanti, Hernandez, Irene, Zogg, Mark, Jia, Shuang, Hessner, Martin J., Toso, Raffaella, Rezaie, Alireza R., Fernández, José A., Camire, Rodney M., Ruf, Wolfram, Griffin, John H., Weiler, Hartmut

“…The key effector molecule of the natural protein C pathway, activated protein C (aPC), exerts pleiotropic effects on coagulation, fibrinolysis, and…”
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Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant by Mosnier, Laurent O., Zampolli, Antonella, Kerschen, Edward J., Schuepbach, Reto A., Banerjee, Yajnavalka, Fernández, José A., Yang, Xia V., Riewald, Matthias, Weiler, Hartmut, Ruggeri, Zaverio M., Griffin, John H.

“…Activated protein C (APC) reduces mortality in severe sepsis patients. APC exerts anticoagulant activities via inactivation of factors Va and VIIIa and…”
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Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5 by Schulteis, Ryan D., Chu, Haiyan, Dai, Xuezhi, Chen, Yuhong, Edwards, Brandon, Haribhai, Dipica, Williams, Calvin B., Malarkannan, Subramaniam, Hessner, Martin J., Glisic-Milosavljevic, Sanja, Jana, Srikanta, Kerschen, Edward J., Ghosh, Soumitra, Wang, Demin, Kwitek, Anne E., Lernmark, Ake, Gorski, Jack, Weiler, Hartmut

“…The loss of Gimap5 (GTPase of the immune-associated protein 5) gene function is the underlying cause of lymphopenia and autoimmune diabetes in the BioBreeding…”
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Caveolin-1–dependent apoptosis induced by fibrin degradation products by Guo, Yi-He, Hernandez, Irene, Isermann, Berend, Kang, Tae-bong, Medved, Leonid, Sood, Rashmi, Kerschen, Edward J., Holyst, Trudy, Mosesson, Michael W., Weiler, Hartmut

“…In mice lacking the blood coagulation regulator thrombomodulin, fibrinolytic degradation products (FDP) of fibrin induce apoptotic cell death of a specialized…”
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snr-1 Gene Is Required for Nitrate Reduction in Pseudomonas aeruginosa PAO1 by Kerschen, E J, Irani, V R, Hassett, D J, Rowe, J J

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Coagulation Factor V Mediates Inhibition of Tissue Factor Signaling By Activated Protein C by Weiler, Hartmut, Liang, Hai-Po, Kerschen, Edward J, Rezaie, Alireza, Fernandez, Jose A., Camire, Rodney M., Ruf, Wolfram, Griffin, John H., Toso, Raffaele

“…BACKGROUND: The key effector molecule of the natural protein C pathway, activated protein C (aPC), exerts pleiotropic effects on coagulation, fibrinolysis, and…”
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Factor V Inhibits PAR2-Mediated Lethal Inflammation by Kerschen, Edward J, Liang, Hai-Po Helena, Fernandez, Jose A., Toso, Raffaella, Ruf, Wolfram, Camire, Rodney M., Griffin, John H., Weiler, Hartmut

“…Abstract 3360 The Leiden polymorphism (Arg506Gln) in human blood coagulation factor V (fV) is the most prevalent genetic risk factor for venous thrombosis. We…”
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Pharmacological targeting of the thrombomodulin–protein C pathway mitigates radiation toxicity by Geiger, Hartmut, Pawar, Snehalata A, Kerschen, Edward J., Nattamai, Kalpana J., Hernandez, Irene, Liang, Hai Po, Fernández, Jose Á, Cancelas, Jose A., Ryan, Marnie A., Kustikova, Olga, Schambach, Axel, Fu, Qiang, Wang, Junru, Fink, Louis M., Petersen, Karl-Uwe, Zhou, Daohong, Griffin, John H., Baum, Christopher, Weiler, Hartmut, Hauer-Jensen, Martin

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Mechanisms for Mortality Reduction by Activated Protein C in Severe Sepsis by Kerschen, Edward J., Cooley, Brian C., Castellino, Francis J., Coughlin, Shaun R., Fernandez, Jose A., Griffin, John H., Weiler, Hartmut

“…Recombinant wild type (wt) activated protein C (APC) reduces patient mortality in severe sepsis and multi-organ failure. APC can exert both anticoagulant…”
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Protective Effect of Activated Protein C in Murine Endotoxemia: Mechanism of Action by Kerschen, Edward J., Cooley, Brian C., Castellino, Francis J., Griffin, John H., Weiler, Hartmut

“…Recombinant activated protein C (APC) reduces mortality of patients with severe inflammatory disease associated with multi-organ failure. APC exerts…”
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Instability of a vortex sheet leaving a right-angled corner by Davis, Anthony M. J., Kerschen, Edward J.

“…David Crighton had a long-standing interest in how the results of Orszag and Crow [Stud. Appl. Math. 49, 167–181 (1970)], for the instability of a vortex sheet…”
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