Search Results - "Kers, Inger"

Aryl Hphosphonates. 8. Simple and efficient method forv the preparation of nucleoside Hphosphonothioate monoesters by Kers, Inger, Kers, Annika, Stawiński, Jacek, Kraszewski, Adam

“…An efficient method for the preparation of nucleoside 3′-Hphosphonothioate monoesters was developed. It consists of phosphonylation of suitably protected…”
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Aryl H-Phosphonates. 6. Synthetic Studies on the Preparation of Nucleoside N-Alkyl-H-phosphonamidates by Sobkowska, Anna, Sobkowski, Michał, Cieślak, Jacek, Kraszewski, Adam, Kers, Inger, Stawiński, Jacek

“…Various approaches to the synthesis of nucleoside H-phosphonamidates have been investigated. Direct couplings of nucleoside H-phosphonates with amines have…”
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Phenethyl nicotinamides, a novel class of Na(V)1.7 channel blockers: structure and activity relationship by Kers, Inger, Macsari, Istvan, Csjernyik, Gabor, Nylöf, Martin, Skogholm, Karin, Sandberg, Lars, Minidis, Alexander, Bueters, Tjerk, Malmborg, Jonas, Eriksson, Anders B, Lund, Per-Eric, Venyike, Elisabet, Luo, Lei, Nyström, Jan-Erik, Besidski, Yevgeni

“…The Na(V)1.7 ion channel is an attractive target for development of potential analgesic drugs based on strong genetic links between mutations in the gene…”
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Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers by Kers, Inger, Csjernyik, Gabor, Macsari, Istvan, Nylöf, Martin, Sandberg, Lars, Skogholm, Karin, Bueters, Tjerk, Eriksson, Anders B., Oerther, Sandra, Lund, Per-Eric, Venyike, Elisabet, Nyström, Jan-Erik, Besidski, Yevgeni

“…Recent findings showing a relation between mutations in the NaV1.7 channel in humans and altered pain sensation has contributed to increase the attractiveness…”
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Phenethyl nicotinamides, a novel class of NaV1.7 channel blockers: Structure and activity relationship by Kers, Inger, Macsari, Istvan, Csjernyik, Gabor, Nylöf, Martin, Skogholm, Karin, Sandberg, Lars, Minidis, Alexander, Bueters, Tjerk, Malmborg, Jonas, Eriksson, Anders B., Lund, Per-Eric, Venyike, Elisabet, Luo, Lei, Nyström, Jan-Erik, Besidski, Yevgeni

“…The NaV1.7 ion channel is an attractive target for development of potential analgesic drugs based on strong genetic links between mutations in the gene coding…”
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Potent and orally efficacious benzothiazole amides as TRPV1 antagonists by Besidski, Yevgeni, Brown, William, Bylund, Johan, Dabrowski, Michael, Dautrey, Sophie, Harter, Magali, Horoszok, Lucy, Hu, Yin, Johnson, Dean, Johnstone, Shawn, Jones, Paul, Leclerc, Sandrine, Kolmodin, Karin, Kers, Inger, Labarre, Maryse, Labrecque, Denis, Laird, Jennifer, Lundström, Therese, Martino, John, Maudet, Mickaël, Munro, Alexander, Nylöf, Martin, Penwell, Andrea, Rotticci, Didier, Slaitas, Andis, Sundgren-Andersson, Anna, Svensson, Mats, Terp, Gitte, Villanueva, Huascar, Walpole, Christopher, Zemribo, Ronald, Griffin, Andrew M.

“…Benzothiazole amides were identified as TRPV1 antagonists from high throughput screening. Compound 37 maintained potent antagonism with improved metabolic…”
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Search for the Optimal Linker in Tandem Hairpin Polyamides by Kers, Inger, Dervan, Peter B

“…In order to target specific DNA sequences ≥10 base pairs in size by minor groove binding ligands, a search for the optimal linker in dimers of hairpin…”
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Aryl H-phosphonates. 10. Synthesis of nucleoside phosphoramidate and nucleoside phosphoramidothioate analogues via H-phosphonamidate intermediates by Kers, Inger, Stawiński, Jacek, Kraszewski, Adam

“…Synthesis of a new type of dinucleoside monophosphate analogue with the 3′–5′ H-phosphonamidate internucleoside linkage, namely thymidin-3′-yl…”
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A new synthetic method for the preparation of nucleoside phosphoramidate analogues with the nitrogen atom in bridging positions of the phosphoramidate linkage by Kers, Inger, Stawiński, Jacek, Kraszewski, Adam

“…An efficient method for the preparation of nucleoside P3′→N5′ and N3′→P5′ phosphoramidates and their thio analogues results from generation of a pyridine…”
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Studies on aryl H-phosphonates. 3. Mechanistic investigations related to the disproportionation of diphenyl H-phosphonate under anhydrous basic conditions by Kers, Annika, Kers, Inger, Stawiński, Jacek, Sobkowski, Michał, Kraszewski, Adam

“…Diphenyl H-phosphonate undergoes under anhydrous reaction conditions a base-promoted disproportionation to triphenyl phosphite and phenyl H-phosphonate. On the…”
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Nucleoside Phosphoramidate Analogues with Modification in the Bridging Positions of the Phosphodiester Linkage by Kers, Inger, Kraszewski, Adam, Stawinski, Jacek

“…Phosphoramidate modified DNA oligomersl[1] have recently been shown to have promising properties for antisensdantigene applications. An eficient method, for…”
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New Methods for the Formation of the P-N and P-F Bonds, their Relevance to Nucleotide and Oligonucleotide Analogues Synthesis by Kers, Inger, Bollmark, Martin, Kraszewski, Adam, Stawinski, Jacek

“…Two approaches have been developed for the formation of phosphoramidates with the nitrogen atom in bridging positions of the internucleotide linkage. One of…”
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Synthesis of 2′,3′-dideoxy-3′,4′-dihydroxymethyl substituted pyrimidine nucleoside analogues by Björsne, Magnus, Classon, Björn, Kers, Inger, Samuelsson, Bertil, Kvarnström, Ingemar

“…Some 2′,3′-dideoxy-3′,4′-dihydroxymethyl nucleoside analogues have been synthesised using an aldol condensation followed by in situ cross Canizzaro reduction…”
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31P NMR studies on the activation pathways of aryl H-phosphonate esters with condensing agents by Kers, Annika, Kers, Inger, Kraszewski, Adam, Stawinski, Jacek

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Synthesis and anti-retroviral activity of O,O'-bis(3'-azido-2',3'-dideoxythymidin-5'-yl) phosphoramidate derivatives by Kers, I, Stawiński, J, Girardet, J L, Imbach, J L, Périgaud, C, Gosselin, G, Aubertin, A M

“…A simple and efficient protocol for the preparation of various symmetrical dinucleoside phosphoramidates derived from AZT, is presented. It consists of the…”
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