Search Results - "Kerros, Céline"
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Reduction of cell proliferation and potentiation of Fas-induced apoptosis by the selective kappa-opioid receptor agonist U50 488 in the multiple myeloma LP-1 cells
Published in Journal of neuroimmunology (30-03-2010)“…Abstract As opioid receptors modulate proliferation and apoptosis of immune cells, we hypothesized that they could reduce malignant haematopoietic cells. After…”
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Somatostatin and opioid receptors do not regulate proliferation or apoptosis of the human multiple myeloma U266 cells
Published in Journal of experimental & clinical cancer research (07-06-2009)“…opioid and somatostatin receptors (SSTRs) that can assemble as heterodimer were individually reported to modulate malignant cell proliferation and to favour…”
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Targeting the Leukemia Antigen PR1 with Immunotherapy for the Treatment of Multiple Myeloma
Published in Clinical cancer research (15-07-2018)“…PR1 is a human leukocyte antigen (HLA)-A2 nonameric peptide derived from neutrophil elastase (NE) and proteinase 3 (P3). We have previously shown that PR1 is…”
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Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target
Published in Frontiers in immunology (25-01-2018)“…Cathepsin G (CG) is a myeloid azurophil granule protease that is highly expressed by acute myeloid leukemia (AML) blasts and leukemia stem cells. We previously…”
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The peptide derived from the Ig-like domain of human herpesvirus 8 K1 protein induces death in hematological cancer cells
Published in Journal of experimental & clinical cancer research (28-08-2012)“…Although significant progress has been made in the treatment of lymphomas, many lymphomas exhibit resistance to cell death, suggesting a defective Fas…”
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A Public Neoantigen Produced By the SF3B1 K700E Mutation Is a Bona Fide T Cell Target in AML/MDS
Published in Blood (02-11-2023)“…Myelodysplastic syndrome (MDS) is a life-threatening disease in which malignant bone marrow cells fail to differentiate, resulting in anemia, cytopenia, and…”
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High-Throughput Identification of Graft-Vs-Leukemia TCRs in AML Patient Samples after Allogeneic Stem Cell Transplantation
Published in Blood (02-11-2023)“…For patients with intermediate and high-risk AML/MDS, allogeneic stem cell transplantation (aSCT) is a potentially curative therapy. Efficacy is driven by the…”
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CD47 Blockade Enhances Phagocytic Activity of the TCR-Mimic Antibody Hu8F4 Against HLA-A2+ AML
Published in Blood (02-11-2023)“…Hu8F4, a humanized monoclonal antibody that recognizes PR1/HLA-A2 complex, is a first-in-class T cell receptor (TCR) - mimic antibody is currently being tested…”
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3045 – MOLECULAR EVOLUTION OF MEASURABLE RESIDUAL DISEASE IN MYELODYSPLASTIC SYNDROMES
Published in Experimental hematology (01-08-2024)“…Stem cell transplantation (SCT) is the sole curative approach for MDS. However, MDS relapse post-SCT, driven by MRD progression, presents the major obstacle to…”
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Phase I Study of the T-Cell Receptor-like Antibody, Hu8F4 in Patients with Relapsed and Refractory Myeloid Malignancies
Published in Blood (02-11-2023)“…Background: Relapse after conventional chemotherapy for newly diagnosed AML is responsible for the majority of treatment failure. Relapsed (R/R) disease is…”
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Pembrolizumab in Combination with Antigen-Specific Cytotoxic T Lymphocytes Enhances Killing of Acute Myeloid Leukemia
Published in Blood (23-11-2021)“…Background Pembrolizumab, an antibody that blocks programmed cell death protein 1 (PD-1), has been FDA approved for several solid tumors and hematologic…”
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Humanized T Cell Receptor-like Antibody Hu8F4 Reduces Leukemia By Fc-Mediated Mechanism
Published in Blood (15-11-2022)Get full text
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Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation
Published in The Journal of immunology (1950) (01-09-2018)“…Proteinase 3 (P3), a serine protease expressed by myeloid cells, localized within azurophil granules, and also expressed on the cellular membrane of…”
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Fucosylation Enhances the Efficacy of Adoptively Transferred Antigen-Specific Cytotoxic T Lymphocytes
Published in Clinical cancer research (15-04-2019)“…Inefficient homing of adoptively transferred cytotoxic T lymphocytes (CTLs) to tumors is a major limitation to the efficacy of adoptive cellular therapy (ACT)…”
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Characterization of Changes in the T-Cell Receptor Repertoire in Patients with Acute Myeloid Leukemia with Durable Remission Following Allogeneic Stem Cell Transplant
Published in Blood (13-11-2019)“…Introduction: Allogeneic hematopoietic stem-cell transplantation (HSCT) is curative for many patients with advanced hematologic cancers, including adverse-risk…”
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Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells
Published in The Journal of biological chemistry (16-06-2017)“…Neutrophil elastase (NE) can be rapidly taken up by tumor cells that lack endogenous NE expression, including breast cancer, which results in…”
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Abstract 1516: Deep profiling of T-cell repertoire and tumor heterogeneity in chronic lymphocytic leukemia patients following allogeneic T-cell therapy
Published in Cancer research (Chicago, Ill.) (15-08-2020)“…Chemotherapy/ targeted therapy are both known to trigger evolution of treatment resistant clones that can lead to relapse. Allogeneic stem cell transplant…”
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Characterizing the Mechanism of NE and P3 Cross-Presentation in B Cell-Acute Lymphoblastic Leukemia
Published in Blood (08-12-2017)“…Introduction PR1 is a nonameric HLA-A2 restricted leukemia-associated antigen derived from serine proteases neutrophil elastase (NE) and proteinase 3 (P3). NE…”
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Pembrolizumab Enhances the Anti-Leukemia Activity of Antigen Specific Cytotoxic T Lymphocytes
Published in Blood (29-11-2018)“…▪ Many aggressive hematologic malignancies are exquisitely responsive to immunotherapy. While allogeneic (allo) hematopoietic stem cell transplantation (SCT)…”
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Abstract 3984: Neuropilin-1 mediates neutrophil elastase uptake and antigen cross-presentation in breast cancer cells
Published in Cancer research (Chicago, Ill.) (01-07-2017)“…We previously showed that soluble neutrophil elastase (NE) is rapidly taken up by tumor cells that lack endogenous NE expression, including breast cancer…”
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