Search Results - "Kerrigan, John"

Hypothalamic hamartoma with epilepsy: Review of endocrine comorbidity by Harrison, Victor S., Oatman, Oliver, Kerrigan, John F.

“…Summary The most common, and usually the only, endocrine disturbance in patients with hypothalamic hamartoma (HH) and epilepsy is central precocious puberty…”
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Ketogenic Diet Treatment for Pediatric Super-Refractory Status Epilepticus by Appavu, Brian, Vanatta, Lisa, Condie, John, Kerrigan, John F, Jarrar, Randa

“…Highlights • 10 children received the ketogenic diet for super-refractory status epilepticus. • 9 children had resolution of status epilepticus after diet…”
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Hypothalamic Hamartomas: Evolving Understanding and Management by Cohen, Nathan T., Cross, J. Helen, Arzimanoglou, Alexis, Berkovic, Samuel F., Kerrigan, John F., Miller, Ilene Penn, Webster, Erica, Soeby, Lisa, Cukiert, Arthur, Hesdorffer, Dale K., Kroner, Barbara L., Saper, Clifford B., Schulze-Bonhage, Andreas, Gaillard, William D.

“…Hypothalamic hamartomas (HH) are rare, basilar developmental lesions with widespread comorbidities often associated with refractory epilepsy and…”
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Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development by Tedeschi, Philip M, Vazquez, Alexei, Kerrigan, John E, Bertino, Joseph R

“…Rapidly proliferating tumors attempt to meet the demands for nucleotide biosynthesis by upregulating folate pathways that provide the building blocks for…”
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NAD+ Kinase as a Therapeutic Target in Cancer by Tedeschi, Philip M, Bansal, Nitu, Kerrigan, John E, Abali, Emine E, Scotto, Kathleen W, Bertino, Joseph R

“…NAD kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD ) to nicotinamide adenine dinucleotide phosphate (NADP ) using ATP as…”
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Magnetic Resonance Imaging-Guided Laser Interstitial Thermal Therapy for the Treatment of Hypothalamic Hamartomas: A Retrospective Review by Xu, David S, Chen, Tsinsue, Hlubek, Randall J, Bristol, Ruth E, Smith, Kris A, Ponce, Francisco A, Kerrigan, John F, Nakaji, Peter

“…Abstract BACKGROUND Hypothalamic hamartomas (HH) are rare lesions associated with treatment-resistant epilepsy. Open surgery results in modest seizure control…”
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Hypothalamic hamartoma: Neuropathology and epileptogenesis by Kerrigan, John F., Parsons, Angela, Tsang, Candy, Simeone, Kristina, Coons, Stephen, Wu, Jie

“…Summary Hypothalamic hamartomas (HHs) are congenital malformations of the ventral hypothalamus resulting in treatment‐resistant epilepsy and are intrinsically…”
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Psychiatric comorbidity with hypothalamic hamartoma: Systematic review for predictive clinical features by Killeen, Zachary, Bunch, Raymond, Kerrigan, John F

“…Abstract Objective We conducted a systematic review of the English-language literature to identify clinical features associated with a higher risk of…”
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Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction by Hu, Longqin, Magesh, Sadagopan, Chen, Lin, Wang, Lili, Lewis, Timothy A., Chen, Yu, Khodier, Carol, Inoyama, Daigo, Beamer, Lesa J., Emge, Thomas J., Shen, Jian, Kerrigan, John E., Kong, Ah-Ng Tony, Dandapani, Sivaraman, Palmer, Michelle, Schreiber, Stuart L., Munoz, Benito

“…A high-throughput screen (HTS) of the MLPCN library using a homogenous fluorescence polarization assay identified a small molecule as a first-in-class direct…”
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Network‐targeted approach and postoperative resting‐state functional magnetic resonance imaging are associated with seizure outcome by Boerwinkle, Varina L., Cediel, Emilio G., Mirea, Lucia, Williams, Korwyn, Kerrigan, John F., Lam, Sandi, Raskin, Jeffrey S., Desai, Virendra R., Wilfong, Angus A., Adelson, P. David, Curry, Daniel J.

“…Objective Postoperative resting‐state functional magnetic resonance imaging (MRI) in children with intractable epilepsy has not been quantified in relation to…”
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Achieving a cure for hypothalamic hamartomas: a Sisyphean quest? by Régis, Jean, Helen Cross, J., Kerrigan, John F.

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Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy by Hildebrand, Michael S., Griffin, Nicole G., Damiano, John A., Cops, Elisa J., Burgess, Rosemary, Ozturk, Ezgi, Jones, Nigel C., Leventer, Richard J., Freeman, Jeremy L., Harvey, A. Simon, Sadleir, Lynette G., Scheffer, Ingrid E., Major, Heather, Darbro, Benjamin W., Allen, Andrew S., Goldstein, David B., Kerrigan, John F., Berkovic, Samuel F., Heinzen, Erin L.

“…Hypothalamic hamartoma (HH) with gelastic epilepsy is a well-recognized drug-resistant epilepsy syndrome of early life.1 Surgical resection allows limited…”
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Topoisomerase IIβ-mediated DNA double-strand breaks : Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane by LYU, Yi Lisa, KERRIGAN, John E, LIN, Chao-Po, AZAROVA, Anna M, TSAI, Yuan-Chin, YI BAN, LIU, Leroy F

“…Abstract Doxorubicin is among the most effective and widely used anticancer drugs in the clinic. However, cardiotoxicity is one of the life-threatening side…”
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Long term outcome after surgical treatment for hypothalamic hamartoma by Kulkarni, Neil, Nageotte, Rachel Ayn, Klamer, Brett G., Rekate, Harold L., Bristol, Ruth E., Scharnweber, Travis, Bobrowitz, Margaret, Kerrigan, John F.

“…To determine long-term outcome for seizure control and clinical predictors for seizure freedom in patients undergoing surgical treatment for epilepsy…”
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A “Close” Look at Linear Approximations by Kerrigan, John

“…Students use Desmos to investigate nonlinear functions in small neighborhoods around the origin…”
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Subcentimeter epilepsy surgery targets by resting state functional magnetic resonance imaging can improve outcomes in hypothalamic hamartoma by Boerwinkle, Varina L., Foldes, Stephen T., Torrisi, Salvatore J., Temkit, Hamy, Gaillard, William D., Kerrigan, John F., Desai, Virendra R., Raskin, Jeffrey S., Vedantam, Aditya, Jarrar, Randa, Williams, Korwyn, Lam, Sandi, Ranjan, Manish, Broderson, Janna S., Adelson, David, Wilfong, Angus A., Curry, Daniel J.

“…Summary Objective The purpose of this study is to investigate the outcomes of epilepsy surgery targeting the subcentimeter‐sized resting state functional…”
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Tumor stroma interaction is mediated by monocarboxylate metabolism by Patel, Brijesh B., Ackerstaff, Ellen, Serganova, Inna S., Kerrigan, John E., Blasberg, Ronald G., Koutcher, Jason A., Banerjee, Debabrata

“…Human breast tumors contain significant amounts of stromal cells. There exists strong evidence that these stromal cells support cancer development and…”
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Electrical Stimulation of the Anterior Nucleus of the Thalamus for the Treatment of Intractable Epilepsy by Kerrigan, John F., Litt, Brian, Fisher, Robert S., Cranstoun, Stephen, French, Jacqueline A., Blum, David E., Dichter, Marc, Shetter, Andrew, Baltuch, Gordon, Jaggi, Jurg, Krone, Selma, Brodie, MaryAnn, Rise, Mark, Graves, Nina

“…Purpose: Animal studies and sporadic case reports in human subjects have suggested that intermittent electrical stimulation of the anterior nucleus of the…”
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Non-Directed Allylic C-H Acetoxylation in the Presence of Lewis Basic Heterocycles by Malik, Hasnain A, Taylor, Buck L H, Kerrigan, John R, Grob, Jonathan E, Houk, K N, Du Bois, J, Hamann, Lawrence G, Patterson, Andrew W

“…We outline a strategy to enable non-directed Pd(II)-catalyzed C-H functionalization in the presence of Lewis basic heterocycles. In a high-throughput screen of…”
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Sporadic hypothalamic hamartoma is a ciliopathy with somatic and bi-allelic contributions by Green, Timothy E, Motelow, Joshua E, Bennett, Mark F, Ye, Zimeng, Bennett, Caitlin A, Griffin, Nicole G, Damiano, John A, Leventer, Richard J, Freeman, Jeremy L, Harvey, A Simon, Lockhart, Paul J, Sadleir, Lynette G, Boys, Amber, Scheffer, Ingrid E, Major, Heather, Darbro, Benjamin W, Bahlo, Melanie, Goldstein, David B, Kerrigan, John F, Heinzen, Erin L, Berkovic, Samuel F, Hildebrand, Michael S

“…Abstract Hypothalamic hamartoma with gelastic seizures is a well-established cause of drug-resistant epilepsy in early life. The development of novel surgical…”
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