Search Results - "Kerrick, W. Glenn L."

nNOS splice variants differentially regulate myofilament function but are dispensable for intracellular calcium and force transients in cardiac papillary muscles by Kerrick, W Glenn L, Xu, Yuanyuan, Percival, Justin M

“…Cardiac muscle expresses three neuronal nitric oxide synthase (nNOS) splice variants: nNOSα, nNOSμ and nNOSβ. The functions of these nNOS splice variants in…”
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Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice by Kerrick, W. Glenn L, Kazmierczak, Katarzyna, Xu, Yuanyuan, Wang, Yingcai, Szczesna-Cordary, Danuta

“…Transgenic (Tg) mice expressing ~95% of the D166V (aspartic acid to valine) mutation in the ventricular myosin regulatory light chain (RLC) shown to cause a…”
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Functional Consequences of the Human Cardiac Troponin I Hypertrophic Cardiomyopathy Mutation R145G in Transgenic Mice by Wen, Yuhui, Pinto, Jose Renato, Gomes, Aldrin V., Xu, Yuanyuan, Wang, Yingcai, Wang, Ying, Potter, James D., Kerrick, W. Glenn L.

“…In this study, we addressed the functional consequences of the human cardiac troponin I (hcTnI) hypertrophic cardiomyopathy R145G mutation in transgenic mice…”
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The Role of the N-Terminus of the Myosin Essential Light Chain in Cardiac Muscle Contraction by Kazmierczak, Katarzyna, Xu, Yuanyuan, Jones, Michelle, Guzman, Georgianna, Hernandez, Olga M., Kerrick, W. Glenn L., Szczesna-Cordary, Danuta

“…To study the regulation of cardiac muscle contraction by the myosin essential light chain (ELC) and the physiological significance of its N-terminal extension,…”
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Functional effects of a restrictive-cardiomyopathy-linked cardiac troponin I mutation (R145W) in transgenic mice by Wen, Yuhui, Xu, Yuanyuan, Wang, Yingcai, Pinto, Jose Renato, Potter, James D, Kerrick, W Glenn L

“…The human cardiac troponin I (hcTnI) mutation R145W has been associated with restrictive cardiomyopathy. In this study, simultaneous measurements of ATPase…”
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Triadins Modulate Intracellular Ca2+ Homeostasis but Are Not Essential for Excitation-Contraction Coupling in Skeletal Muscle by Shen, Xiaohua, Franzini-Armstrong, Clara, Lopez, Jose R., Jones, Larry R., Kobayashi, Yvonne M., Wang, Ying, Kerrick, W. Glenn L., Caswell, Anthony H., Potter, James D., Miller, Todd, Allen, Paul D., Perez, Claudio F.

“…To unmask the role of triadin in skeletal muscle we engineered pan-triadin-null mice by removing the first exon of the triadin gene. This resulted in a total…”
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Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients by Szczesna-Cordary, Danuta, Jones, Michelle, Moore, Jeffrey R, Watt, James, Kerrick, W. Glenn L, Xu, Yuanyuan, Wang, Ying, Wagg, Cory, Lopaschuk, Gary D

“…The glutamic acid to lysine mutation at the 22nd amino acid residue (E22K) in the human cardiac myosin regulatory light chain (RLC) gene causes familial…”
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F110I and R278C Troponin T Mutations That Cause Familial Hypertrophic Cardiomyopathy Affect Muscle Contraction in Transgenic Mice and Reconstituted Human Cardiac Fibers by Hernandez, Olga M., Szczesna-Cordary, Danuta, Knollmann, Björn C., Miller, Todd, Bell, Michael, Zhao, Jiaju, Sirenko, Syevda G., Diaz, Zoraida, Guzman, Georgianna, Xu, Yuanyuan, Wang, Ying, Kerrick, W. Glenn L., Potter, James D.

“…We have studied the physiological effects of the troponin T (TnT) F110I and R278C mutations associated with familial hypertrophic cardiomyopathy (FHC) in…”
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Different Functional Properties of Troponin T Mutants That Cause Dilated Cardiomyopathy by Venkatraman, Gayathri, Harada, Keita, Gomes, Aldrin V., Kerrick, W.Glenn L., Potter, James D.

“…The effects of Troponin T (TnT) mutants R141W and ΔK210, the only two currently known mutations in TnT that cause dilated cardiomyopathy(DCM) independent of…”
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Characterization of Troponin T Dilated Cardiomyopathy Mutations in the Fetal Troponin Isoform by Venkatraman, Gayathri, Gomes, Aldrin V., Kerrick, W. Glenn L., Potter, James D.

“…The major goal of this study was to elucidate how troponin T (TnT) dilated cardiomyopathy (DCM) mutations in fetal TnT and fetal troponin affect the functional…”
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Inorganic phosphate affects the pCa-force relationship more than the pCa-ATPase by increasing the rate of dissociation of force generating cross-bridges in skinned fibers from both EDL and soleus muscles of the rat by Kerrick, W Glenn L, Xu, Yuanyuan

“…The effect of inorganic phosphate (Pi) on Ca2+ -activation of actomyosin ATPase activity and force in permeabilized (skinned) single extensor digitorum longus…”
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Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations by Wang, Ying, Xu, Yuanyuan, Kerrick, W Glenn L, Wang, Yingcai, Guzman, Georgianna, Diaz-Perez, Zoraida, Szczesna-Cordary, Danuta

“…Clinical studies have revealed that mutations in the ventricular myosin regulatory light chain (RLC) lead to the development of familial hypertrophic…”
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Triadins modulate intracellular Ca(2+) homeostasis but are not essential for excitation-contraction coupling in skeletal muscle by Shen, Xiaohua, Franzini-Armstrong, Clara, Lopez, Jose R, Jones, Larry R, Kobayashi, Yvonne M, Wang, Ying, Kerrick, W Glenn L, Caswell, Anthony H, Potter, James D, Miller, Todd, Allen, Paul D, Perez, Claudio F

“…To unmask the role of triadin in skeletal muscle we engineered pan-triadin-null mice by removing the first exon of the triadin gene. This resulted in a total…”
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Fluorescent Probes Attached to Cys 35 or Cys 84 in Cardiac Troponin C Are Differentially Sensitive to Ca2+-Dependent Events in Vitro and in Situ by Putkey, John A, Liu, Wen, Lin, Xin, Ahmed, Saadia, Zhang, Mei, Potter, James D, Kerrick, W. Glenn L

“…The goal of the current study was to generate recombinant cTnC proteins with single Cys residues as sites for attachment of fluorescent probes that can…”
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The off rate of Ca(2+) from troponin C is regulated by force-generating cross bridges in skeletal muscle by Wang, Ying, Kerrick, W Glenn L

“…The effects of dissociation of force-generating cross bridges on intracellular Ca(2+), pCa-force, and pCa-ATPase relationships were investigated in mouse…”
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The off rate of Ca2+ from troponin C is regulated by force-generating cross bridges in skeletal muscle by Wang, Ying, Kerrick, W. Glenn L

“…Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33101 The effects of dissociation of force-generating cross…”
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Abnormal Contractile Function in Transgenic Mice Expressing a Familial Hypertrophic Cardiomyopathy-linked Troponin T (I79N) Mutation by Miller, Todd, Szczesna, Danuta, Housmans, Philippe R., Zhao, Jiaju, de Freitas, Fatima, Gomes, Aldrin V., Culbreath, Lieneke, McCue, Jessica, Wang, Yi, Xu, Yuanyuan, Kerrick, W. Glenn L., Potter, James D.

“…This study characterizes a transgenic animal model for the troponin T (TnT) mutation (I79N) associated with familial hypertrophic cardiomyopathy. To study the…”
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Activation of Striated Muscle: Nearest-neighbor Regulatory-unit and Cross-bridge Influence on Myofilament Kinetics by Robinson, John M., Wang, Ying, Kerrick, W.Glenn L., Kawai, Ryoichi, Cheung, Herbert C.

“…We have formulated a three-compartment model of muscle activation that includes both strong cross-bridge (XB) and Ca 2+-activated regulatory-unit (RU) mediated…”
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Ca2+ measurements in skinned cardiac fibers: effects of Mg2+ on Ca2+ activation of force and fiber ATPase by Allen, Keri, Xu, Yuan Yuan, Kerrick, W. Glenn L

“…Department of Physiology and Biophysics, University of Miami School of Medicine, Miami, Florida 33101 In contrast to previous studies, a new fluorescent method…”
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Troponin C regulates the rate constant for the dissociation of force-generating myosin cross-bridges in cardiac muscle by Wang, Y, Xu, Y, Guth, K, Kerrick, W G

“…It is well known that cardiac troponin C (cTnC) regulates the association of force-generating myosin cross-bridges. We report here evidence for an additional…”
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