Search Results - "Kerr Whitfield, G."

Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells by Forster, Ryan E., Jurutka, Peter W., Hsieh, Jui-Cheng, Haussler, Carol A., Lowmiller, Christine L., Kaneko, Ichiro, Haussler, Mark R., Kerr Whitfield, G.

“…► Both klotho mRNA spliceforms are regulated by 1,25-dihydroxyvitamin D (1,25D). ► Regulation occurs in cell lines from kidney proximal, distal and collecting…”
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1,25‐Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D by Kaneko, Ichiro, Sabir, Marya S., Dussik, Christopher M., Whitfield, G. Kerr, Karrys, Amitis, Hsieh, Jui‐Cheng, Haussier, Mark R., Meyer, Mark B., Pike, J. Wesley, Jurutka, Peter W.

“…ABSTRACT To investigate vitamin D‐related control of brain‐expressed genes, candidate vitamin D responsive elements (VDREs) at ‐7/‐10 kb in human tryptophan…”
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Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport ( SERT ) and degradation ( MAO-A ) gene expression in cultured rat serotonergic neuronal cell lines by Sabir, Marya S, Haussler, Mark R, Mallick, Sanchita, Kaneko, Ichiro, Lucas, Daniel A, Haussler, Carol A, Whitfield, G Kerr, Jurutka, Peter W

“…Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D (1,25D; active vitamin D metabolite), are…”
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Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review by El Sayed, Khalid, Whitfield, G. Kerr, Chamcheu, Jean Christopher, Kuiate, Jules-Roger, Babatunde, A. S., Mohamed, Hadir, Anwar, Md Rafi, Banang Mbeumi, Sergette, Chamcheu, Roxane-Cherille N., Bloch, Melissa B., Rady, Islam, Noubissi, Felicite K.

“…Graviola (Annona muricata) is a small deciduous tropical evergreen fruit tree, belonging to the Annonaceae family, and is widely grown and distributed in…”
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Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers by Maatough, Anas, Whitfield, G. Kerr, Brook, Lemlem, Hsieh, David, Palade, Patricia, Hsieh, Jui‐Cheng

“…ABSTRACT The mammalian hairless protein (HR) is a 130 kDa nuclear transcription factor that is essential for proper skin and hair follicle function. Previous…”
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Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention by Haussler, Mark R, Haussler, Carol A, Bartik, Leonid, Whitfield, G. Kerr, Hsieh, Jui-Cheng, Slater, Stephanie, Jurutka, Peter W

“…The human vitamin D receptor (VDR) is a key nuclear receptor that binds nutritionally derived ligands and exerts bioeffects that contribute to bone mineral…”
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The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging by Haussler, Mark R., Haussler, Carol A., Whitfield, G. Kerr, Hsieh, Jui-Cheng, Thompson, Paul D., Barthel, Thomas K., Bartik, Leonid, Egan, Jan B., Wu, Yifei, Kubicek, Jana L., Lowmiller, Christine L., Moffet, Eric W., Forster, Ryan E., Jurutka, Peter W.

“…The nuclear vitamin D receptor (VDR) binds 1,25-dihydroxyvitamin D 3 (1,25D), its high affinity renal endocrine ligand, to signal intestinal calcium and…”
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Functional Diversification of Vitamin D Receptor Paralogs in Teleost Fish After a Whole Genome Duplication Event by Kollitz, Erin M, Hawkins, Mary Beth, Whitfield, G. Kerr, Kullman, Seth W

“…The diversity and success of teleost fishes (Actinopterygii) has been attributed to three successive rounds of whole-genome duplication (WGD). WGDs provide a…”
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Vitamin D Receptor as an Intestinal Bile Acid Sensor by Makishima, Makoto, Lu, Timothy T., Xie, Wen, Whitfield, G. Kerr, Domoto, Hideharu, Evans, Ronald M., Haussler, Mark R., Mangelsdorf, David J.

“…The vitamin D receptor (VDR) mediates the effects of the calcemic hormone 1α,25-dihydroxyvitamin D3[1,25(OH)2D 3]. We show that VDR also functions as a…”
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Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling by Chamcheu, Jean Christopher, Rady, Islam, Chamcheu, Roxane-Cherille N, Siddique, Abu Bakar, Bloch, Melissa B, Banang Mbeumi, Sergette, Babatunde, Abiola S, Uddin, Mohammad B, Noubissi, Felicite K, Jurutka, Peter W, Liu, Yong-Yu, Spiegelman, Vladimir S, Whitfield, G Kerr, El Sayed, Khalid A

“…Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC…”
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Resveratrol Potentiates Vitamin D and Nuclear Receptor Signaling by Dampf Stone, Angelika, Batie, Shane F., Sabir, Marya S., Jacobs, Elizabeth T., Lee, Jamie H., Whitfield, G. Kerr, Haussler, Mark R., Jurutka, Peter W.

“…ABSTRACT The 1,25‐dihydroxyvitamin D3 (1,25D) hormone is derived from vitamin D generated in skin or obtained from the diet, and binds to and activates the…”
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The role of vitamin D in the FGF23, klotho, and phosphate bone-kidney endocrine axis by Haussler, Mark R., Whitfield, G. Kerr, Kaneko, Ichiro, Forster, Ryan, Saini, Rimpi, Hsieh, Jui-Cheng, Haussler, Carol A., Jurutka, Peter W.

“…1,25-dihydroxyvitamin D (1,25D), through association with the nuclear vitamin D receptor (VDR), exerts control over a novel endocrine axis consisting of the…”
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Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention by Bartik, Leonid, Whitfield, G. Kerr, Kaczmarska, Magdalena, Lowmiller, Christine L., Moffet, Eric W., Furmick, Julie K., Hernandez, Zachary, Haussler, Carol A., Haussler, Mark R., Jurutka, Peter W.

“…The nuclear vitamin D receptor (VDR) mediates the actions of 1,25-dihydroxyvitamin D 3 (1,25D) to regulate gene transcription. Recently, the secondary bile…”
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FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes by Kaneko, Ichiro, Saini, Rimpi K, Griffin, Kristin P, Whitfield, G Kerr, Haussler, Mark R, Jurutka, Peter W

“…In a closed endocrine loop, 1,25-dihydroxyvitamin D3 (1,25D) induces the expression of fibroblast growth factor 23 (FGF23) in bone, with the phosphaturic…”
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Vitamin D Receptor: Key Roles in Bone Mineral Pathophysiology, Molecular Mechanism of Action, and Novel Nutritional Ligands by Jurutka, Peter W, Bartik, Leonid, Whitfield, G Kerr, Mathern, Douglas R, Barthel, Thomas K, Gurevich, Miriam, Hsieh, Jui‐Cheng, Kaczmarska, Magdalena, Haussler, Carol A, Haussler, Mark R

“…The vitamin D hormone, 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3], binds with high affinity to the nuclear vitamin D receptor (VDR), which recruits its retinoid X…”
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Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis by Karrys, Amitis, Rady, Islam, Chamcheu, Roxane-Cherille N, Sabir, Marya S, Mallick, Sanchita, Chamcheu, Jean Christopher, Jurutka, Peter W, Haussler, Mark R, Whitfield, G Kerr

“…Treatment with 1,25-dihydroxyvitamin D₃ (1,25D) improves psoriasis symptoms, possibly by inducing the expression of late cornified envelope ( )3 genes involved…”
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Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership by Kollitz, Erin M, Zhang, Guozhu, Hawkins, Mary Beth, Whitfield, G Kerr, Reif, David M, Kullman, Seth W

“…The evolution, molecular behavior, and physiological function of nuclear receptors are of particular interest given their diverse roles in regulating essential…”
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Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates by Kollitz, Erin M, Zhang, Guozhu, Hawkins, Mary Beth, Whitfield, G Kerr, Reif, David M, Kullman, Seth W

“…The vertebrate genome is a result of two rapid and successive rounds of whole genome duplication, referred to as 1R and 2R. Furthermore, teleost fish have…”
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1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism by Barthel, Thomas K., Mathern, Douglas R., Whitfield, G. Kerr, Haussler, Carol A., Hopper, H. Andrew, Hsieh, Jui-Cheng, Slater, Stephanie A., Hsieh, Grace, Kaczmarska, Magdalena, Jurutka, Peter W., Kolek, Olga I., Ghishan, Fayez K., Haussler, Mark R.

“…1,25-Dihydroxyvitamin D3 (1,25D) is known primarily as a regulator of calcium, but 1,25D also promotes phosphate absorption from intestine, reabsorption from…”
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Vitamin D receptor-mediated control of Soggy, Wise, and Hairless gene expression in keratinocytes by Hsieh, Jui-Cheng, Estess, Rudolf C, Kaneko, Ichiro, Whitfield, G Kerr, Jurutka, Peter W, Haussler, Mark R

“…The vitamin D receptor (VDR), but not its hormonal ligand, 1,25-dihydroxyvitamin D3 (1,25D), is required for the progression of the mammalian hair cycle. We…”
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