Search Results - "Kerr, Mark S."

Enantioselective Synthesis of Quaternary Stereocenters via a Catalytic Asymmetric Stetter Reaction by Kerr, Mark S, Rovis, Tomislav

“…A new electron-deficient chiral triazolium salt has been shown to catalyze the formation of quaternary stereocenters by an asymmetric intramolecular Stetter…”
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An Efficient Synthesis of Achiral and Chiral 1,2,4-Triazolium Salts:  Bench Stable Precursors for N-Heterocyclic Carbenes by Kerr, Mark S, Read de Alaniz, Javier, Rovis, Tomislav

“…The promising utility of triazolyl N-heterocyclic carbene catalysts in umpolung aldehyde chemistry requires a straightforward reliable synthesis from readily…”
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Scope of the Asymmetric Intramolecular Stetter Reaction Catalyzed by Chiral Nucleophilic Triazolinylidene Carbenes by de Alaniz, Javier Read, Kerr, Mark S, Moore, Jennifer L, Rovis, Tomislav

“…A highly enantioselective intramolecular Stetter reaction of aromatic and aliphatic aldehydes tethered to different Michael acceptors has been developed. Two…”
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A Highly Enantioselective Catalytic Intramolecular Stetter Reaction by Kerr, Mark S, Read de Alaniz, Javier, Rovis, Tomislav

“…A family of chiral triazolium salts has been developed for inducing the asymmetric intramolecular Stetter reaction. The use of an aminoindanol-derived catalyst…”
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A General Approach to Optically Pure, α‑Methyl Non-Natural Amino Acids: Enabling Unique Peptides as Drug Candidates by Passley, Kyle D., Ruble, J. Craig, Kerr, Mark S., Organ, Michael G.

“…An α-methyl, non-natural amino acid (NNAA) building block equipped with an alkyl halide tail that could be readily transformed into an organozinc was prepared…”
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Solid potential by Kerr, Mark S., Cole, Kevin P.

“…Small-molecule drug discovery and development is limited by the ability of chemists to readily synthesize and purify new compounds with suitable chemical…”
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Sustainability case studies on the use of continuous manufacturing in pharmaceutical production by Kerr, Mark S., Cole, Kevin P.

“…Continuous processing is now commonly used in the manufacturing of fine chemicals including agrochemicals and pharmaceuticals. Datasets are now available,…”
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A Continuous Flow Process for LSN647712 via Double Organometallic Additions to Dimethylcarbamyl Chloride by Li, Hui, Sheeran, Jillian W, Kouvchinov, David, Clausen, Andrew M, Crouch, Ian T, Bio, Matthew M, Fang, Yuan-Qing, Frank, Scott A, Johnson, Martin D, Kerr, Mark S

“…The ketone intermediate LSN647712 is a key synthetic intermediate for the drug substance lasmiditan manufacturing process. A three-step connected continuous…”
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Enantioselective formation of quaternary stereocenters using the catalytic intramolecular Stetter reaction by Moore, Jennifer L., Kerr, Mark S., Rovis, Tomislav

“…Asymmetric formation of quaternary stereocenters has been accomplished using the catalytic intramolecular Stetter reaction. A variety of tethered aldehydes and…”
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Practical Asymmetric Synthesis of an Edivoxetine·HCl Intermediate via an Efficient Diazotization Process by Kopach, Michael E, Heath, Perry C, Scherer, Roger B, Pietz, Mark A, Astleford, Bret A, McCauley, Mary Kay, Singh, Utpal K, Wong, Sze Wing, Coppert, David M, Kerr, Mark S, Houghton, Peter G, Rhodes, Gary A, Tharp, Gregg A

“…A convergent synthesis of (S)-(4-benzylmorpholin-2-yl)­(morpholino)­methanone methanesulfonate (1), a key regulatory starting material for edivoxetine·HCl, was…”
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Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction by Calvin, Joel R., Boyse, Raymond, Braden, Timothy M., Brewer, Alison C., Changi, Shujauddin, Harrold, Donal, Johnson, Martin, Kerr, Mark S., Lambertus, Gordon R., Luciani, Carla V., May, Scott A., Moloney, Harold, Murphy, John D., Roberts, Jeffrey C., Schafer, John P., Spencer, Richard D., Webster, Luke P.

“…A synthetic route to API was designed containing a Negishi cross-coupling reaction, where the zincate reagent was generated by transmetalation of a Grignard…”
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An Efficient Synthesis of Achiral and Chiral 1,2,4-Triazolium Salts: Bench Stable Precursors for by Kerr, Mark S., de Alaniz, Javier Read, Rovis, Tomislav

“…The promising utility of triazolyl N -heterocyclic carbene catalysts in umpolung aldehyde chemistry requires a straightforward reliable synthesis from readily…”
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An efficient synthesis of achiral and chiral 1,2,4-triazolium salts : Bench stable precursors for Ν-heterocyclic carbenes by KERR, Mark S, DE ALANIZ, Javier Read, ROVIS, Tomislav

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A cost-effective method to enhance adenoviral transduction of primary murine osteoblasts and bone marrow stromal cells by Buo, Atum M, Williams, Mark S, Kerr, Jaclyn P, Stains, Joseph P

“…We report here a method for the use of poly-L-lysine （PLL） to markedly improve the adenoviral transduction efficiency of primary murine osteoblasts and bone…”
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