Search Results - "Kerr, Jaclyn"

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle by Kerr, Jaclyn P., Robison, Patrick, Shi, Guoli, Bogush, Alexey I., Kempema, Aaron M., Hexum, Joseph K., Becerra, Natalia, Harki, Daniel A., Martin, Stuart S., Raiteri, Roberto, Prosser, Benjamin L., Ward, Christopher W.

“…In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress transduced by the microtubule network elicits reactive oxygen species…”
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Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging by Palla, Adelaida R., Hilgendorf, Keren I., Yang, Ann V., Kerr, Jaclyn P., Hinken, Aaron C., Demeter, Janos, Kraft, Peggy, Mooney, Nancie A., Yucel, Nora, Burns, David M., Wang, Yu Xin, Jackson, Peter K., Blau, Helen M.

“…During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases, diminishing the ability of muscle to repair following injury. We found that the…”
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Runet's Critical Juncture: The Ukraine War and the Battle for the Soul of the Web by Kerr, Jaclyn A

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Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes by Lyons, James S, Joca, Humberto C, Law, Robert A, Williams, Katrina M, Kerr, Jaclyn P, Shi, Guoli, Khairallah, Ramzi J, Martin, Stuart S, Konstantopoulos, Konstantinos, Ward, Christopher W, Stains, Joseph P

“…The adaptation of the skeleton to its mechanical environment is orchestrated by mechanosensitive osteocytes, largely by regulating the abundance of sclerostin,…”
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Toward Trustworthy and Responsible Artificial Intelligence Policy Development by Madhavan, Raj, Kerr, Jaclyn A., Corcos, Amanda R., Isaacoff, Benjamin P.

“…Artificial intelligence (AI) technologies are already creating new sectors of the economy and revitalizing industries. Governments and societies around the…”
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Dysferlin stabilizes stress-induced Ca²⁺ signaling in the transverse tubule membrane by Kerr, Jaclyn P., Ziman, Andrew P., Mueller, Amber L., Muriel, Joaquin M., Kleinhans-Welte, Emily, Gumerson, Jessica D., Vogel, Steven S., Ward, Christopher W., Roche, Joseph A., Bloch, Robert J.

“…Dysferlinopathies, most commonly limb girdle muscular dystrophy 2B and Miyoshi myopathy, are degenerative myopathies caused by mutations in the DYSF gene…”
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Recovery of altered neuromuscular junction morphology and muscle function in mdx mice after injury by Pratt, Stephen J. P, Shah, Sameer B, Ward, Christopher W, Kerr, Jaclyn P, Stains, Joseph P, Lovering, Richard M

“…Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which weakness, increased susceptibility to muscle injury, and inadequate repair…”
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Keratin 18 is an integral part of the intermediate filament network in murine skeletal muscle by Muriel, Joaquin M, O'Neill, Andrea, Kerr, Jaclyn P, Kleinhans-Welte, Emily, Lovering, Richard M, Bloch, Robert J

“…Intermediate filaments (IFs) contribute to force transmission, cellular integrity, and signaling in skeletal muscle. We previously identified keratin 19…”
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Single-color, ratiometric biosensors for detecting signaling activities in live cells by Ross, Brian L, Tenner, Brian, Markwardt, Michele L, Zviman, Adam, Shi, Guoli, Kerr, Jaclyn P, Snell, Nicole E, McFarland, Jennifer J, Mauban, Joseph R, Ward, Christopher W, Rizzo, Megan A, Zhang, Jin

“…Genetically encoded fluorescent biosensors have revolutionized the study of signal transduction by enabling the real-time tracking of signaling activities in…”
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Dysferlin at transverse tubules regulates Ca(2+) homeostasis in skeletal muscle by Kerr, Jaclyn P, Ward, Christopher W, Bloch, Robert J

“…The class of muscular dystrophies linked to the genetic ablation or mutation of dysferlin, including Limb Girdle Muscular Dystrophy 2B (LGMD2B) and Miyoshi…”
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Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle by Zhang, Hengtao, Bryson, Victoria Graham, Wang, Chaojian, Li, TianYu, Kerr, Jaclyn P, Wilson, Rebecca, Muoio, Deborah M, Bloch, Robert J, Ward, Christopher, Rosenberg, Paul B

“…Stromal interaction molecule 1 (STIM1), the sarcoplasmic reticulum (SR) transmembrane protein, activates store-operated Ca2+ entry (SOCE) in skeletal muscle…”
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The Phosphorylation Profile of Myosin Binding Protein-C Slow is Dynamically Regulated in Slow-Twitch Muscles in Health and Disease by Ackermann, Maegen A., Kerr, Jaclyn P., King, Brendan, W. Ward, Christopher, Kontrogianni-Konstantopoulos, Aikaterini

“…Myosin Binding Protein-C slow (sMyBP-C) is expressed in skeletal muscles where it plays structural and regulatory roles. The functions of sMyBP-C are modulated…”
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Human skeletal muscle xenograft as a new preclinical model for muscle disorders by Zhang, Yuanfan, King, Oliver D, Rahimov, Fedik, Jones, Takako I, Ward, Christopher W, Kerr, Jaclyn P, Liu, Naili, Emerson, Jr, Charles P, Kunkel, Louis M, Partridge, Terence A, Wagner, Kathryn R

“…Development of novel therapeutics requires good animal models of disease. Disorders for which good animal models do not exist have very few drugs in…”
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A cost-effective method to enhance adenoviral transduction of primary murine osteoblasts and bone marrow stromal cells by Buo, Atum M, Williams, Mark S, Kerr, Jaclyn P, Stains, Joseph P

“…We report here a method for the use of poly-L-lysine （PLL） to markedly improve the adenoviral transduction efficiency of primary murine osteoblasts and bone…”
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Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle by Kombairaju, Ponvijay, Kerr, Jaclyn P, Roche, Joseph A, Pratt, Stephen J P, Lovering, Richard M, Sussan, Thomas E, Kim, Jung-Hyun, Shi, Guoli, Biswal, Shyam, Ward, Christopher W

“…Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we discovered a pathway by which mechanical stretch activates NADPH…”
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Synemin isoforms differentially organize cell junctions and desmin filaments in neonatal cardiomyocytes by Lund, Linda M., Kerr, Jaclyn P., Lupinetti, Jenna, Zhang, Yinghua, Russell, Mary A., Bloch, Robert J., Bond, Meredith

“…ABSTRACT Intermediate filaments (IFs) in cardiomyocytes consist primarily of desmin, surround myofibrils at Z disks, and transmit forces from the contracting…”
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Correction to: HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction induced injury by Billin, Andrew N, Honeycutt, Samuel E, McDougal, Alan V, Kerr, Jaclyn P, Chen, Zhe, Freudenberg, Johannes M, Rajpal, Deepak K, Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S, Fang, Frank, Yao, Bert, Clark, Richard V, Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C, Russell, Alan J

“…Following publication of the original article [1], the authors flagged that there is a discrepancy with the Availability of data and materials statement on…”
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Corrigendum: The Phosphorylation Profile of Myosin Binding Protein-C Slow is Dynamically Regulated in Slow-Twitch Muscles in Health and Disease by Ackermann, Maegen A, Kerr, Jaclyn P, King, Brendan, Ward, Christopher W, Kontrogianni-Konstantopoulos, Aikaterini

“…This corrects the article DOI: 10.1038/srep12637…”
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HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury by Billin, Andrew N, Honeycutt, Samuel E, McDougal, Alan V, Kerr, Jaclyn P, Chen, Zhe, Freudenberg, Johannes M, Rajpal, Deepak K, Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S, Fang, Frank, Yao, Bert, Clark, Richard V, Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C, Russell, Alan J

“…In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect…”
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Dysferlin at transverse tubules regulates Ca2+ homeostasis in skeletal muscle by Kerr, Jaclyn P., Ward, Christopher W., Bloch, Robert J.

“…The class of muscular dystrophies linked to the genetic ablation or mutation of dysferlin, including Limb Girdle Muscular Dystrophy 2B (LGMD2B) and Miyoshi…”
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