Search Results - "Kerr, Ian D"

ABC transporter research: going strong 40 years on by Theodoulou, Frederica L, Kerr, Ian D

“…In most organisms, ABC transporters constitute one of the largest families of membrane proteins. In humans, their functions are diverse and underpin numerous…”
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The multidrug transporter ABCG2: still more questions than answers by Horsey, Aaron J, Cox, Megan H, Sarwat, Sunehera, Kerr, Ian D

“…ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated…”
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Detergent-free purification of ABC (ATP-binding-cassette) transporters by Gulati, Sonali, Jamshad, Mohammed, Knowles, Timothy J, Morrison, Kerrie A, Downing, Rebecca, Cant, Natasha, Collins, Richard, Koenderink, Jan B, Ford, Robert C, Overduin, Michael, Kerr, Ian D, Dafforn, Timothy R, Rothnie, Alice J

“…ABC (ATP-binding-cassette) transporters carry out many vital functions and are involved in numerous diseases, but study of the structure and function of these…”
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Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner by Jackson, Hannah K, Mitoko, Christine, Linke, Franziska, Macarthur, Donald, Kerr, Ian D, Coyle, Beth

“…Extracellular vesicles (EVs) have emerged as pivotal mediators of communication in the tumour microenvironment. More specifically, nanosized extracellular…”
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Intrinsic acyl-CoA thioesterase activity of a peroxisomal ATP binding cassette transporter is required for transport and metabolism of fatty acids by De Marcos Lousa, Carine, van Roermund, Carlo W. T., Postis, Vincent L. G., Dietrich, Daniela, Kerr, Ian D., Wanders, Ronald J. A., Baldwin, Stephen A., Baker, Alison, Theodoulou, Frederica L.

“…Peroxisomes are organelles that perform diverse metabolic functions in different organisms, but a common function is β-oxidation of a variety of long chain…”
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ABCB1 in children's brain tumours by Coyle, Beth, Kessler, Maya, Sabnis, Durgagauri H, Kerr, Ian D

“…Tumours of the central nervous system are the most common solid tumour, accounting for a quarter of the 1500 cases of childhood cancer diagnosed each year in…”
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Analysis of Sequence Divergence in Mammalian ABCGs Predicts a Structural Network of Residues That Underlies Functional Divergence by Mitchell-White, James I, Stockner, Thomas, Holliday, Nicholas, Briddon, Stephen J, Kerr, Ian D

“…The five members of the mammalian G subfamily of ATP-binding cassette transporters differ greatly in their substrate specificity. Four members of the subfamily…”
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Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein by Mittra, Rituparna, Pavy, Megan, Subramanian, Nanditha, George, Anthony M., O'Mara, Megan L., Kerr, Ian D., Callaghan, Richard

“…[Display omitted] The multidrug resistance P-glycoprotein (P-gp) is characterised by the ability to bind and/or transport an astonishing array of drugs. This…”
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Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature by Taylor, Louisa, Wade, Philippa K, Johnson, James E C, Aldighieri, Macha, Morlando, Sonia, Di Leva, Gianpiero, Kerr, Ian D, Coyle, Beth

“…Therapy resistance represents an unmet challenge in the treatment of medulloblastoma. Accordingly, the identification of targets that mark drug-resistant cell…”
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Disruption of the Unique ABCG-Family NBD:NBD Interface Impacts Both Drug Transport and ATP Hydrolysis by Kapoor, Parth, Briggs, Deborah A, Cox, Megan H, Kerr, Ian D

“…ABCG2 is one of a triumvirate of human multidrug ATP binding cassette (ABC) transporters that are implicated in the defense of cells and tissues against…”
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Tackling Anticancer Drug Resistance and Endosomal Escape in Aggressive Brain Tumors Using Bioelectronics by Jain, Akhil, Wade, Philippa, Stolnik, Snow, Hume, Alistair N., Kerr, Ian D., Coyle, Beth, Rawson, Frankie

“…Resistance mechanisms in brain tumors, such as medulloblastoma and glioblastoma, frequently involve the entrapment of chemotherapeutic agents within endosomes…”
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A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma by Sabnis, Durgagauri H., Storer, Lisa C. D., Liu, Jo-Fen, Jackson, Hannah K., Kilday, J. P., Grundy, Richard G., Kerr, Ian D., Coyle, Beth

“…Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasion and recurrence. We hypothesised that these hallmarks were…”
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Sequence analysis of twin ATP binding cassette proteins involved in translational control, antibiotic resistance, and ribonuclease L inhibition by Kerr, Ian D

“…Genome sequencing has identified open reading frames which belong to the ATP binding cassette (ABC) transporter family, but which are unlikely to be involved…”
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The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis by Wonderen, Jessica H., McMahon, Róisin M., O'Mara, Megan L., McDevitt, Christopher A., Thomson, Andrew J., Kerr, Ian D., MacMillan, Fraser, Callaghan, Richard

“…Understanding the process that underlies multidrug recognition and efflux by P‐glycoprotein (ABCB1) remains a key biological challenge. Structural data have…”
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Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences by Haider, Ameena J, Cox, Megan H, Jones, Natalie, Goode, Alice J, Bridge, Katherine S, Wong, Kelvin, Briggs, Deborah, Kerr, Ian D

“…ABCG2 is an ABC (ATP-binding cassette) transporter with a physiological role in urate transport in the kidney and is also implicated in multi-drug efflux from…”
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Structure-function analysis of the presumptive Arabidopsis auxin permease AUX1 by Swarup, R, Kargul, J, Marchant, A, Zadik, D, Rahman, A, Mills, R, Yemm, A, May, S, Williams, L, Millner, P

“…We have investigated the subcellular localization, the domain topology, and the amino acid residues that are critical for the function of the presumptive…”
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New insight into the biochemical mechanisms regulating auxin transport in plants by Kerr, Ian D, Bennett, Malcolm J

“…The transport of the plant hormone auxin has been under intense investigation since its identification 80 years ago. Studies have gradually refined our…”
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Polymorphisms of the Multidrug Pump ABCG2: A Systematic Review of Their Effect on Protein Expression, Function, and Drug Pharmacokinetics by Heyes, Niall, Kapoor, Parth, Kerr, Ian D

“…The widespread expression and polyspecificity of the multidrug ABCG2 efflux transporter make it an important determinant of the pharmacokinetics of a variety…”
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Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging by Linke, Franziska, Johnson, James E C, Kern, Stefanie, Bennett, Christopher D, Lourdusamy, Anbarasu, Lea, Daniel, Clifford, Steven C, Merry, Catherine L R, Stolnik, Snow, Alexander, Morgan R, Peet, Andrew C, Scurr, David J, Griffiths, Rian L, Grabowska, Anna M, Kerr, Ian D, Coyle, Beth

“…The most common malignant brain tumour in children, medulloblastoma (MB), is subdivided into four clinically relevant molecular subgroups, although targeted…”
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Improving the stability and function of purified ABCB1 and ABCA4: The influence of membrane lipids by Pollock, Naomi L., McDevitt, Christopher A., Collins, Richard, Niesten, Petronella H.M., Prince, Stephen, Kerr, Ian D., Ford, Robert C., Callaghan, Richard

“…ATP Binding Cassette (ABC) transporters play prominent roles in numerous cellular processes and many have been implicated in human diseases. Unfortunately,…”
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