Search Results - "Kerr, G"
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Factors affecting outcomes in patients reaching end-stage kidney disease worldwide: differences in access to renal replacement therapy, modality use, and haemodialysis practices
Published in The Lancet (British edition) (16-07-2016)“…Summary More than 2 million people worldwide are being treated for end-stage kidney disease (ESKD). This Series paper provides an overview of incidence,…”
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Molecular Mechanisms of Vitamin D Action
Published in Calcified tissue international (01-02-2013)“…The hormonal metabolite of vitamin D, 1α,25-dihydroxyvitamin D 3 (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR). When…”
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PHYSICAL PROPERTIES OF WHITE-LIGHT SOURCES IN THE 2011 FEBRUARY 15 SOLAR FLARE
Published in The Astrophysical journal (10-03-2014)“…White-light flares (WLFs) are observational rarities, making them understudied events. However, optical emission is a significant contribution to flare energy…”
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High rates of death and hospitalization follow bone fracture among hemodialysis patients
Published in Kidney international (01-01-2014)“…Altered bone structure and function contribute to the high rates of fractures in dialysis patients compared to the general population. Fracture events may…”
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The effect of standing posture on amplitude and variability of postural tremor in Parkinson’s disease
Published in Neuroscience letters (14-05-2023)“…•Tremor is a common motor problem associated with older adults with Parkinson’s disease.•Impact of an individual’s postural position (i.e. sitting vs standing)…”
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Predictors of future falls in Parkinson disease
Published in Neurology (13-07-2010)“…Falls are a major health and injury problem for people with Parkinson disease (PD). Despite the severe consequences of falls, a major unresolved issue is the…”
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1,25‐Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D
Published in The FASEB journal (01-09-2015)“…ABSTRACT To investigate vitamin D‐related control of brain‐expressed genes, candidate vitamin D responsive elements (VDREs) at ‐7/‐10 kb in human tryptophan…”
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The fragility of significant results underscores the need of larger randomized controlled trials in nephrology
Published in Kidney international (01-12-2017)“…The Fragility Index is a tool for testing robustness of randomized controlled trial results for dichotomous outcomes. It describes the minimum number of…”
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Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport ( SERT ) and degradation ( MAO-A ) gene expression in cultured rat serotonergic neuronal cell lines
Published in Genes & nutrition (11-07-2018)“…Diminished brain levels of two neurohormones, 5-hydroxytryptamine (5-HT; serotonin) and 1,25-dihydroxyvitamin D (1,25D; active vitamin D metabolite), are…”
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Patient and Caregiver Priorities for Outcomes in Hemodialysis: An International Nominal Group Technique Study
Published in American journal of kidney diseases (01-09-2016)“…Background In the context of clinical research, investigators have historically selected the outcomes that they consider to be important, but these are often…”
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Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers
Published in Journal of cellular biochemistry (01-01-2018)“…ABSTRACT The mammalian hairless protein (HR) is a 130 kDa nuclear transcription factor that is essential for proper skin and hair follicle function. Previous…”
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The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase
Published in Nature communications (26-05-2022)“…The pleiotropic function of long noncoding RNAs is well recognized, but their direct role in governing metabolic homeostasis is less understood. Here, we…”
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Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells
Published in Biochemical and biophysical research communications (28-10-2011)“…► Both klotho mRNA spliceforms are regulated by 1,25-dihydroxyvitamin D (1,25D). ► Regulation occurs in cell lines from kidney proximal, distal and collecting…”
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Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
Published in Oxidative medicine and cellular longevity (01-01-2018)“…Graviola (Annona muricata) is a small deciduous tropical evergreen fruit tree, belonging to the Annonaceae family, and is widely grown and distributed in…”
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TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1
Published in Science signaling (18-05-2010)“…The activation and fusion of macrophages and of osteoclasts require the adaptor molecule DNAX-activating protein of 12 kD (DAP12), which contains…”
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Predicting the bodily self in space and time
Published in Scientific reports (27-06-2024)“…To understand how the human brain distinguishes itself from external stimulation, it was examined if motor predictions enable healthy adult volunteers to infer…”
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Microencapsulation and in situ incubation methodology for the cultivation of marine bacteria
Published in Frontiers in microbiology (22-08-2022)“…Environmental microorganisms are important sources of biotechnology innovations; however, the discovery process is hampered by the inability to culture the…”
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Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial
Published in Brain (London, England : 1878) (01-09-2008)“…Olfactory ensheathing cells show promise in preclinical animal models as a cell transplantation therapy for repair of the injured spinal cord. This is a report…”
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Post-traumatic stress disorder and serum cytokine and chemokine concentrations in patients with rheumatoid arthritis
Published in Seminars in arthritis and rheumatism (01-10-2019)“…Although post-traumatic stress disorder (PTSD) is identified as a risk factor in the development of rheumatoid arthritis (RA), associations of PTSD with…”
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Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis
Published in Kidney international (01-11-2015)“…Myeloperoxidase (MPO) is an important neutrophil lysosomal enzyme, a major autoantigen, and a potential mediator of tissue injury in MPO-ANCA-associated…”
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