Search Results - "Kerr, DIB"

Characterization of novel gabapentin analogues implicated in analgesia by Parker, DAS, Ong, J, Kerr, DIB, Marino, V

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Arylalkylamines are a novel class of positive allosteric modulators at GABA(B) receptors in rat neocortex by Kerr, David I B, Ong, Jennifer, Puspawati, Ni Made, Prager, Rolf H

“…Using grease-gap recording from rat neocortical slices, the gamma-aminobutyric acid(B) (GABA(B)) receptor agonists baclofen (3-100 microM) and SKF 97541…”
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3-Chloro,4-methoxyfendiline is a potent GABA(B) receptor potentiator in rat neocortical slices by Ong, Jennifer, Parker, David A S, Marino, Victor, Kerr, David I B, Puspawati, Ni Made, Prager, Rolf H

“…Using grease-gap recording from rat neocortical slices, the GABA(B) receptor agonist baclofen elicited reversible and concentration-dependent hyperpolarizing…”
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GABA sub(B) receptors: Targets for drug development by Kerr, DIB, Ong, J

“…GABA is a major inhibitory neurotransmitter in the CNS where it regulates neuronal excitability. These actions of GABA are mediated through GABA receptor…”
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Comparative activities of the enantiomeric GABA(B) receptor agonists CGP 44532 and 44533 in central and peripheral tissues by Ong, J, Bexis, S, Marino, V, Parker, D A, Kerr, D I, Froestl, W

“…In neocortical slices maintained in Mg(2+)-free Krebs medium, the gamma-aminobutyric acid (GABA(B)) receptor agonists baclofen,…”
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CGP 36216 is a selective antagonist at GABA(B) presynaptic receptors in rat brain by Ong, J, Bexis, S, Marino, V, Parker, D A, Kerr, D I, Froestl, W

“…In rat neocortical preparations maintained in Mg(2+)-free Krebs medium, baclofen depressed the frequency of spontaneous discharges in a concentration-dependent…”
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Effects of Ca2+ concentration on GABA(B) receptor function in rat neocortical slices by Ong, J, Kerr, D I

“…In rat neocortical slices maintained in Mg2+-free Kreb's medium, the effects of Ca2+ concentration on repetitive spontaneous discharges and on GABA(B)…”
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GABA sub(B) receptors by Kerr, DIB, Ong, J

“…GABA sub(B) receptors are a distinct subclass of receptors for the major inhibitory transmitter 4-aminobutanoic acid (GABA) that mediate depression of synaptic…”
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Tonic Activation of Presynaptic GABA sub(B) Receptors in the Opener Neuromuscular Junction of Crayfish by Parnas, I, Rashkovan, G, Ong, Jennifer, Kerr, DIB

“…Release of excitatory transmitter from boutons on crayfish nerve terminals was inhibited by (R.S)-baclofen, an agonist at GABA sub(B) receptors. Baclofen had…”
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GABA agonists and antagonists by Kerr, D I, Ong, J

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GABA-receptors in peripheral tissues by Ong, J, Kerr, D I

“…Gamma-aminobutyric acid (GABA) and its receptors are found in a wide range of peripheral tissues, including parts of the peripheral nervous system, endocrines,…”
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Phaclofen: a peripheral and central baclofen antagonist by Kerr, D I, Ong, J, Prager, R H, Gynther, B D, Curtis, D R

“…Phaclofen, the phosphonic acid derivative of baclofen, reversibly antagonized the depression of the cholinergic twitch response of the guinea pig ileum and…”
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Comparative potencies of CGP 47654A and CGP 46165A as GABA(B) receptor antagonists in rat brain by Ong, J, Kerr, D I, Froestl, W

“…In rat neocortical slices maintained in Mg2+-free Krebs medium, the gamma-aminobutyric acid (GABAB) receptor agonist baclofen concentration-dependently…”
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2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors by Kerr, D I, Ong, J, Johnston, G A, Abbenante, J, Prager, R H

“…2-hydroxy-saclofen (2-OH-S), a sulphonic analogue of baclofen, slightly increased the twitch height and reversibly antagonised the GABA- and baclofen-induced…”
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Actions of thienyl analogs of baclofen at GABA sub(B) receptors in rat neocortical slices by Ong, J, Kerr, DIB, Vaccher, C, Berthelot, P

“…In rat neocortical slices maintained in Mg super(2+)-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h),…”
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The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices by Ong, J, Marino, V, Parker, D A, Kerr, D I, Blythin, D J

“…The pharmacological properties of (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid (Sch 50911) were evaluated on GABA(B) receptors in rat neocortical slices. The…”
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The γ-aminobutyric acid uptake inhibitor NO-711 potentiates 3-aminopropylphosphinic acid-induced actions in rat neocortical slices by Ong, Jennifer, Kerr, David I.B

“…In rat neocortical slices maintained in Mg 2+-free Krebs medium, the GABA B receptor agonists baclofen and 3-aminopropylphosphinic acid dose-dependently…”
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Actions of thienyl analogs of baclofen at GABA(B) receptors in rat neocortical slices by Ong, J, Kerr, D I, Vaccher, C, Berthelot, P

“…In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen and its thienyl analogs, 4-amino-3-(5-chlorothien-2-yl)-butanoic acid (5h),…”
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Morpholin-2-yl-phosphinic acids are potent GABA(B) receptor antagonists in rat brain by Ong, J, Kerr, D I, Bittiger, H, Waldmeier, P C, Baumann, P A, Cooke, N G, Mickel, S J, Froestl, W

“…The pharmacological properties of morpholin-2-yl-phosphinic acids were evaluated on GABA(B) receptors. In rat neocortical slices maintained in Mg2+-free Krebs…”
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3-Amino-2-hydroxy-N-(4-nitrophenyl) propanesulphonamide, a new class of GABA sub(b) receptor antagonist in central and peripheral preparations by Kerr, DIB, Ong, J, Hughes, R, Prager, R H

“…Racemic 3-amino-2-hydroxy-N-(4-nitrophenyl) propanesulphonamide (AHPNS), a sulphonamide analog of GABA, reversibly and competitively antagonised the…”
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