Search Results - "Kerns, Robert J."

Mechanism of Quinolone Action and Resistance by Aldred, Katie J, Kerns, Robert J, Osheroff, Neil

“…Quinolones are one of the most commonly prescribed classes of antibacterials in the world and are used to treat a variety of bacterial infections in humans…”
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Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis by Blower, Tim R., Williamson, Benjamin H., Kerns, Robert J., Berger, James M.

“…Mycobacterium tuberculosis (Mtb) infects one-third of the world’s population and in 2013 accounted for 1.5 million deaths. Fluoroquinolone antibacterials,…”
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Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase by Aldred, Katie J., Blower, Tim R., Kerns, Robert J., Berger, James M., Osheroff, Neil

“…Mycobacterium tuberculosis is a significant source of global morbidity and mortality. Moxifloxacin and other fluoroquinolones are important therapeutic agents…”
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Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance by Aldred, Katie J, McPherson, Sylvia A, Turnbough, Jr, Charles L, Kerns, Robert J, Osheroff, Neil

“…Although quinolones are the most commonly prescribed antibacterials, their use is threatened by an increasing prevalence of resistance. The most common causes…”
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Role of the Water-Metal Ion Bridge in Quinolone Interactions with Escherichia coli Gyrase by Carter, Hannah E, Wildman, Baylee, Schwanz, Heidi A, Kerns, Robert J, Aldred, Katie J

“…Fluoroquinolones are an important class of antibacterials, and rising levels of resistance threaten their clinical efficacy. Gaining a more full understanding…”
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Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal-Ion-Independent Drug–Enzyme Interactions by Aldred, Katie J, Schwanz, Heidi A, Li, Gangqin, McPherson, Sylvia A, Turnbough, Charles L, Kerns, Robert J, Osheroff, Neil

“…Quinolones, which target gyrase and topoisomerase IV, are the most widely prescribed antibacterials worldwide. Unfortunately, their use is threatened by the…”
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Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells by Fink, Brian D, Herlein, Judith A, Yorek, Mark A, Fenner, Amanda M, Kerns, Robert J, Sivitz, William I

“…Mitochondrial-targeted analogs of coenzyme Q (CoQ) are under development to reduce oxidative damage induced by a variety of disease states. However, there is a…”
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Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis by MALIK, Muhammad, MARKS, Kevin R, MUSTAEV, Arkady, XILIN ZHAO, CHAVDA, Kalyan, KERNS, Robert J, DRLICA, Karl

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Novel Approach for Comparing the Abilities of Quinolones To Restrict the Emergence of Resistant Mutants during Quinolone Exposure by MALIK, Muhammad, HOATAM, Gerard, CHAVDA, Kalyan, KERNS, Robert J, DRLICA, Karl

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Factors Affecting Stereocontrol during Glycosidation of 2,3-Oxazolidinone-Protected 1-Tolylthio-N-acetyl-d-glucosamine by Wei, Peng, Kerns, Robert J

“…It is demonstrated that a ring-fused 2,3-oxazolidinone-protected derivative of 1-tolylthio-N-acetyl-d-glucosamine undergoes high-yield glycosidation under mild…”
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Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats by Fink, Brian D., Yu, Liping, Coppey, Lawrence, Obrosov, Alexander, Shevalye, Hanna, Kerns, Robert J., Yorek, Mark A., Sivitz, William I.

“…Previous work by ourselves and others showed that mitoquinone (mitoQ) reduced oxidative damage and prevented hepatic fat accumulation in mice made obese with…”
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Use of Gyrase Resistance Mutants To Guide Selection of 8-Methoxy-Quinazoline-2,4-Diones by GERMAN, Nadezhda, MALIK, Muhammad, ROSEN, Jonathan D, DRLICA, Karl, KERNS, Robert J

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Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones by Oppegard, Lisa M, Streck, Kathryn R, Rosen, Jonathan D, Schwanz, Heidi A, Drlica, Karl, Kerns, Robert J, Hiasa, Hiroshi

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Induction of Mycobacterial Resistance to Quinolone Class Antimicrobials by Malik, Muhammad, Chavda, Kalyan, Zhao, Xilin, Shah, Nirali, Hussain, Syed, Kurepina, Natalia, Kreiswirth, Barry N, Kerns, Robert J, Drlica, Karl

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A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation by Kulkarni, Chaitanya A, Fink, Brian D, Gibbs, Bettine E, Chheda, Pratik R, Wu, Meng, Sivitz, William I, Kerns, Robert J

“…Mitochondrial dysfunction is an underlying pathology in numerous diseases. Delivery of diagnostic and therapeutic cargo directly into mitochondria is a…”
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Effect of N-1/C-8 Ring Fusion and C-7 Ring Structure on Fluoroquinolone Lethality by MALIK, Muhammad, MARKS, Kevin R, SCHWANZ, Heidi A, GERMAN, Nadezhda, DRLICA, Karl, KERNS, Robert J

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Quinolone-Mediated Bacterial Death by DRIICA, Karl, MALIK, Muhammad, KERNS, Robert J, XILIN ZHAO

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding by Mustaev, Arkady, Malik, Muhammad, Zhao, Xilin, Kurepina, Natalia, Luan, Gan, Oppegard, Lisa M, Hiasa, Hiroshi, Marks, Kevin R, Kerns, Robert J, Berger, James M, Drlica, Karl

“…DNA gyrase and topoisomerase IV control bacterial DNA topology by breaking DNA, passing duplex DNA through the break, and then resealing the break. This…”
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Extended applications and potential limitations of ring-fused 2,3-oxazolidinone thioglycosides in glycoconjugate synthesis by Kerns, Robert J, Zha, Congxiang, Benakli, Kamel, Liang, Yu-Zeng

“…The utility of ring-fused 2,3-oxazolidinone derivatives of 2-amino-2-deoxy-thioglycosides in the synthesis of glycopeptide intermediates and building blocks…”
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N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3 by Craciun, Ioana, Fenner, Amanda M, Kerns, Robert J

“…The balance between neutrophil serine proteases (NSPs) and protease inhibitors (PIs) in the lung is a critical determinant for a number of chronic inflammatory…”
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