Search Results - "Kernien, John F"

Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack by Johnson, Chad J, Davis, J Muse, Huttenlocher, Anna, Kernien, John F, Nett, Jeniel E

“…has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of…”
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The Extracellular Matrix of Candida albicans Biofilms Impairs Formation of Neutrophil Extracellular Traps by Johnson, Chad J, Cabezas-Olcoz, Jonathan, Kernien, John F, Wang, Steven X, Beebe, David J, Huttenlocher, Anna, Ansari, Hamayail, Nett, Jeniel E

“…Neutrophils release extracellular traps (NETs) in response to planktonic C. albicans. These complexes composed of DNA, histones, and proteins inhibit Candida…”
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The Interface between Fungal Biofilms and Innate Immunity by Kernien, John F, Snarr, Brendan D, Sheppard, Donald C, Nett, Jeniel E

“…Fungal biofilms are communities of adherent cells surrounded by an extracellular matrix. These biofilms are commonly found during infection caused by a variety…”
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Mechanisms involved in the triggering of neutrophil extracellular traps (NETs) by Candida glabrata during planktonic and biofilm growth by Johnson, Chad J., Kernien, John F., Hoyer, Amanda R., Nett, Jeniel E.

“…Candida spp. adhere to medical devices, such as catheters, forming drug-tolerant biofilms that resist killing by the immune system. Little is known about how C…”
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An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections by Fites, J Scott, Gui, Michael, Kernien, John F, Negoro, Paige, Dagher, Zeina, Sykes, David B, Nett, Jeniel E, Mansour, Michael K, Klein, Bruce S

“…Neutrophils are classically defined as terminally differentiated, short-lived cells; however, neutrophils can be long-lived with phenotypic plasticity. During…”
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Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin by Horton, Mark V, Johnson, Chad J, Kernien, John F, Patel, Tarika D, Lam, Brandon C, Cheong, J Z Alex, Meudt, Jennifer J, Shanmuganayagam, Dhanansayan, Kalan, Lindsay R, Nett, Jeniel E

“…Emerging pathogen causes nosocomial outbreaks of life-threatening invasive candidiasis. It is unclear how this species colonizes skin and spreads in health…”
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Deficits in Col5a2 Expression Result in Novel Skin and Adipose Abnormalities and Predisposition to Aortic Aneurysms and Dissections by Park, Arick C., Phan, Noel, Massoudi, Dawiyat, Liu, Zhenjie, Kernien, John F., Adams, Sheila M., Davidson, Jeffrey M., Birk, David E., Liu, Bo, Greenspan, Daniel S.

“…Classic Ehlers-Danlos syndrome (cEDS) is characterized by fragile, hyperextensible skin and hypermobile joints. cEDS can be caused by heterozygosity for…”
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Echinocandin Treatment of Candida albicans Biofilms Enhances Neutrophil Extracellular Trap Formation by Hoyer, Amanda R, Johnson, Chad J, Hoyer, Matthew R, Kernien, John F, Nett, Jeniel E

“…The nosocomial pathogen forms biofilms on medical devices that persist in the face of antifungals and host defenses. Echinocandins, the most effective…”
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Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis by Smith, Tracy M, Youngblom, Madison A, Kernien, John F, Mohamed, Mohamed A, Fry, Sydney S, Bohr, Lindsey L, Mortimer, Tatum D, O'Neill, Mary B, Pepperell, Caitlin S

“…Tuberculosis (TB), caused by ( ), is a leading cause of death due to infectious disease. TB is not traditionally associated with biofilms, but biofilms are…”
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Neutrophils From Patients With Invasive Candidiasis Are Inhibited by Candida albicans Biofilms by Kernien, John F, Johnson, Chad J, Bayless, Meg L, Chovanec, Jack F, Nett, Jeniel E

“…Invasive candidiasis frequently involves medical device placement. On the surfaces of these devices, can form biofilms and proliferate in adherent layers of…”
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Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata by Horton, Mark V, Johnson, Chad J, Zarnowski, Robert, Andes, Brody D, Schoen, Taylor J, Kernien, John F, Lowman, Douglas, Kruppa, Michael D, Ma, Zuchao, Williams, David L, Huttenlocher, Anna, Nett, Jeniel E

“…Candida auris, a recently emergent fungal pathogen, has caused invasive infections in health care settings worldwide. Mortality rates approach 60% and hospital…”
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Homozygosity and Heterozygosity for Null Col5a2 Alleles Produce Embryonic Lethality and a Novel Classic Ehlers-Danlos Syndrome–Related Phenotype by Park, Arick C, Phillips, Charlotte L, Pfeiffer, Ferris M, Roenneburg, Drew A, Kernien, John F, Adams, Sheila M, Davidson, Jeffrey M, Birk, David E, Greenspan, Daniel S

“…Null alleles for the COL5A1 gene and missense mutations for COL5A1 or the COL5A2 gene underlie cases of classic Ehlers-Danlos syndrome, characterized by…”
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Conserved Inhibition of Neutrophil Extracellular Trap Release by Clinical Candida albicans Biofilms by Kernien, John F, Johnson, Chad J, Nett, Jeniel E

“…biofilms are difficult to eradicate due to their resistance to host defenses and antifungal drugs. Although neutrophils are the primary responder to during…”
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Priority effects dictate community structure and alter virulence of fungal-bacterial biofilms by Cheong, J. Z. Alex, Johnson, Chad J., Wan, Hanxiao, Liu, Aiping, Kernien, John F., Gibson, Angela L. F., Nett, Jeniel E., Kalan, Lindsay R.

“…Polymicrobial biofilms are a hallmark of chronic wound infection. The forces governing assembly and maturation of these microbial ecosystems are largely…”
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Ex Vivo Human and Porcine Skin Effectively Model Candida auris Colonization, Differentiating Robust and Poor Fungal Colonizers by Eix, Emily F, Johnson, Chad J, Wartman, Kayla M, Kernien, John F, Meudt, Jennifer J, Shanmuganayagam, Dhanansayan, Gibson, Angela L F, Nett, Jeniel E

“…Abstract Candida auris proliferates and persists on the skin of patients, often leading to health care-associated infections with high mortality. Here, we…”
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Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species by Negoro, Paige E, Xu, Shuying, Dagher, Zeina, Hopke, Alex, Reedy, Jennifer L, Feldman, Michael B, Khan, Nida S, Viens, Adam L, Alexander, Natalie J, Atallah, Natalie J, Scherer, Allison K, Dutko, Richard A, Jeffery, Jane, Kernien, John F, Fites, J Scott, Nett, Jeniel E, Klein, Bruce S, Vyas, Jatin M, Irimia, Daniel, Sykes, David B, Mansour, Michael K

“…Invasive fungal infections constitute a lethal threat, with patient mortality as high as 90%. The incidence of invasive fungal infections is increasing,…”
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Leukocyte-Associated Ig-like Receptor 1 Inhibits Th1 Responses but Is Required for Natural and Induced Monocyte-Dependent Th17 Responses by Agashe, Vrushali V., Jankowska-Gan, Ewa, Keller, Melissa, Sullivan, Jeremy A., Haynes, Lynn D., Kernien, John F., Torrealba, Jose R., Roenneburg, Drew, Dart, Melanie, Colonna, Marco, Wilkes, David S., Burlingham, William J.

“…Abstract Leukocyte-associated Ig-like receptor 1 (LAIR1) is an ITIM-bearing collagen receptor expressed by leukocytes and is implicated in immune suppression…”
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Mucosal Administration of Collagen V Ameliorates the Atherosclerotic Plaque Burden by Inducing Interleukin 35-dependent Tolerance by Park, Arick C., Huang, Guorui, Jankowska-Gan, Ewa, Massoudi, Dawiyat, Kernien, John F., Vignali, Dario A., Sullivan, Jeremy A., Wilkes, David S., Burlingham, William J., Greenspan, Daniel S.

“…We have shown previously that collagen V (col(V)) autoimmunity is a consistent feature of atherosclerosis in human coronary artery disease and in the Apoe−/−…”
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Characterizing the Inhibition of Neutrophil Extracellular Traps by Candida albicans Biofilms by Kernien, John F

“…Candida albicans is a frequent hospital-acquired fungal pathogen and cause of invasive candidiasis. When grown on surfaces like implanted medical devices as a…”
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Th17 responses to Col V, kα-1-tubulin and vimentin are present early in human development and persist lifelong by Sullivan, Jeremy A, Jankowska-Gan, Ewa, Hegde, Subramanya, Pestrak, Matthew A, Agashe, Vrushali V, Park, Arick C, Brown, Matthew E, Kernien, John F, Wilkes, David S, Kaufman, Dixon B, Greenspan, Daniel S, Burlingham, William J

“…Th17-dependent autoimmune responses can develop after heart or lung transplantation, and are associated with fibro-obliterative forms of chronic rejection…”
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