Search Results - "Kernan, Kelly"

GGC Repeat Expansion and Exon 1 Methylation of XYLT1 Is a Common Pathogenic Variant in Baratela-Scott Syndrome by LaCroix, Amy J., Stabley, Deborah, Sahraoui, Rebecca, Adam, Margaret P., Mehaffey, Michele, Kernan, Kelly, Myers, Candace T., Fagerstrom, Carrie, Anadiotis, George, Akkari, Yassmine M., Robbins, Katherine M., Gripp, Karen W., Baratela, Wagner A.R., Bober, Michael B., Duker, Angela L., Doherty, Dan, Dempsey, Jennifer C., Miller, Daniel G., Kircher, Martin, Bamshad, Michael J., Nickerson, Deborah A., Mefford, Heather C., Sol-Church, Katia

“…Baratela-Scott syndrome (BSS) is a rare, autosomal-recessive disorder characterized by short stature, facial dysmorphisms, developmental delay, and skeletal…”
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Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures by Haynes, Premi, Kernan, Kelly, Zhou, Suk-Lin, Miller, Daniel G

“…Facioscapulohumeral muscular dystrophy (FSHD) is most commonly inherited in an autosomal dominant pattern and caused by the abnormal expression of DUX4 in…”
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Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition : Role of plasmin-activated signals by GUOQIANG ZHANG, KERNAN, Kelly A, COLLINS, Sarah J, XIAOHE CAI, LOPEZ-GUISA, Jesus M, DEGEN, Jay L, SHVIL, Yigal, EDDY, Allison A

“…Plasminogen (Plg) activator inhibitor-1 (PAI-1) is an important fibrosis-promoting molecule. Whether this effect can be attributed to PAI-1's activity as an…”
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In vivo knockdown of nicotinic acetylcholine receptor α1 diminishes aortic atherosclerosis by Zhang, Guoqiang, Marshall, Amanda L, Thomas, Alison L, Kernan, Kelly A, Su, Yanyuan, LeBoeuf, Renee C, Dong, Xiu Rong, Tchao, B.N. Angela

“…Abstract Objective Nicotinic acetylcholine receptor α1 (nAChRα1) was recently identified as a functional cell receptor for urokinase, a potent atherogenic…”
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Novel Signaling Pathway: FIBROBLAST NICOTINIC RECEPTOR α1 BINDS UROKINASE AND PROMOTES RENAL FIBROSIS by Zhang, Guoqiang, Kernan, Kelly A, Thomas, Alison, Collins, Sarah, Song, Yumei, Li, Ling, Zhu, Weizhong, LeBoeuf, Renee C, Eddy, Allison A

“…The nicotinic acetylcholine receptor α1 (nAChRα1) was investigated as a potential fibrogenic molecule in the kidney, given reports that it may be an…”
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Effects of exendin-4, a glucagon like peptide-1 receptor agonist, on neutrophil count and inflammatory cytokines in a rat model of endotoxemia by Yanay, Ofer, Bailey, Adam L, Kernan, Kelly, Zimmerman, Jerry J, Osborne, William R

“…Sepsis remains a major cause of morbidity and mortality. A variety of strategies targeting modulation of the pro-inflammatory response associated with early…”
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Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy by Zhang, Guoqiang, Thomas, Alison L, Marshall, Amanda L, Kernan, Kelly A, Su, Yanyuan, Zheng, Yi, Takano, Jiro, Saido, Takaomi C, Eddy, Allison A

“…The nicotinic acetylcholine receptor α1 (nAChRα1) was investigated as a potential proinflammatory molecule in the kidney, given a recent report that it is an…”
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Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats by Moralejo, Daniel, Yanay, Ofer, Kernan, Kelly, Bailey, Adam, Lernmark, Ake, Osborne, William

“…Obesity and type 2 diabetes (T2D) are two prevalent chronic diseases that have become a major public health concern in industrialized countries. T2D is…”
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Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1 by Yanay, Ofer, Moralejo, Daniel, Kernan, Kelly, Brzezinski, Margaret, Fuller, Jessica M., Barton, Randall W., Lernmark, Ake, Osborne, William R.

“…Background Type 1 diabetes (T1D) in both humans and BioBreeding (BB) rats is an autoimmune disease that results in complete destruction of islets and insulin…”
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A Novel Signaling Pathway by Zhang, Guoqiang, Kernan, Kelly A., Thomas, Alison, Collins, Sarah, Song, Yumei, Li, Ling, Zhu, Weizhong, LeBoeuf, Renee C., Eddy, Allison A.

“…The nicotinic acetylcholine receptor α1 (nAChRα1) was investigated as a potential fibrogenic molecule in the kidney, given reports that it may be an…”
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Real-time imaging of intracellular hydrogen peroxide in pancreatic islets by Neal, Adam, Rountree, Austin, Kernan, Kelly, Van Yserloo, Brian, Zhang, Huiliang, Reed, Benjamin J, Osborne, William, Wang, Wang, Sweet, Ian R

“…A real-time method to measure intracellular hydrogen peroxide (H O ) would be very impactful in characterizing rapid changes that occur in physiologic and…”
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Abstract 5461 In vivo Knockdown of Aortic Nicotinic Acetylcholine Receptor Alpha1 (nAChR α 1) Diminishes Aortic Atherosclerosis and Valve Calcification by Zhang, Guoqiang, Kernan, Kelly A, Thomas, Alison, Su, Yanyuan, Zheng, Yi, LeBoeuf, Renee C, Eddy, Allison A

“…Abstract only Urokinase plasminogen activator (uPA) contributes to atherosclerosis, restenosis and vascular remodeling. We have recently identified nAChR α 1…”
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Nicotinic acetylcholine receptor alpha 1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy by Zhang, Guoqiang, Thomas, Alison L, Marshall, Amanda L, Kernan, Kelly A, Su, Yanyuan, Zheng, Yi, Takano, Jiro, Saido, Takaomi C, Eddy, Allison A

“…The nicotinic acetylcholine receptor alpha 1 (nAChR alpha 1) was investigated as a potential proinflammatory molecule in the kidney, given a recent report that…”
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Nicotinic acetylcholine receptor 1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy by Zhang, Guoqiang, Thomas, Alison L, Marshall, Amanda L, Kernan, Kelly A, Su, Yanyuan, Zheng, Yi, Takano, Jiro, Saido, Takaomi C, Eddy, Allison A

“…The nicotinic acetylcholine receptor α1 (nAChRα1) was investigated as a potential proinflammatory molecule in the kidney, given a recent report that it is an…”
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Prolonged survival and improved glycemia in BB diabetic rats after early sustained exposure to GLP-1 by Yanay, Ofer, Moralejo, Daniel, Kernan, Kelly, Brzezinski, Margaret, Fuller, Jessica M., Barton, Randall, Lernmark, Ake, Osborne, William R.

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A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis by Zhang, Guoqiang, Kernan, Kelly A, Thomas, Alison, Collins, Sarah, Song, Yumei, Li, Ling, Zhu, Weizhong, Leboeuf, Renee C, Eddy, Allison A

“…The nicotinic acetylcholine receptor alpha1 (nAChRalpha1) was investigated as a potential fibrogenic molecule in the kidney, given reports that it may be an…”
Get full text