Search Results - "Kern, Rita M"

Mouse Model for Human Arginase Deficiency by Iyer, Ramaswamy K., Yoo, Paul K., Kern, Rita M., Rozengurt, Nora, Tsoa, Rosemarie, O'Brien, William E., Yu, Hong, Grody, Wayne W., Cederbaum, Stephen D.

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Widespread Expression of Arginase I in Mouse Tissues: Biochemical and Physiological Implications by Yu, Hong, Yoo, Paul K, Aguirre, Claudia C, Tsoa, Rosemarie W, Kern, Rita M, Grody, Wayne W, Cederbaum, Stephen D, Iyer, Ramaswamy K

“…Arginase I (AI), the fifth and final enzyme of the urea cycle, detoxifies ammonia as part of the urea cycle. In previous studies from others, AI was not found…”
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Arginases I and II: do their functions overlap? by Cederbaum, Stephen D, Yu, Hong, Grody, Wayne W, Kern, Rita M, Yoo, Paul, Iyer, Ramaswamy K

“…Arginase, often perceived solely as the last of the now six enzymes of the urea cycle, exists in two forms and has a broad tissue distribution. A cytosolic…”
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Expression of arginase isozymes in mouse brain by Yu, Hong, Iyer, Ramaswamy K., Kern, Rita M., Rodriguez, Williams I., Grody, Wayne W., Cederbaum, Stephen D.

“…The two forms of arginase (AI and AII) in man, identical in enzymatic function, are encoded in separate genes and are expressed differentially in various…”
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Cloning and Characterization of the Human Type II Arginase Gene by Vockley, Joseph G., Jenkinson, Christopher P., Shukla, Hridayabiranjan, Kern, Rita M., Grody, Wayne W., Cederbaum, Stephen D.

“…There are two forms of arginase in humans, both catalyzing the hydrolysis of arginine to ornithine and urea. Recent studies in animal models and in Type I…”
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Expression of the liver form of arginase in erythrocytes by Kim, Phillip S, Iyer, Ramaswamy K, Lu, Kan V, Yu, Hong, Karimi, Ardeshir, Kern, Rita M, Tai, Denice K, Cederbaum, Stephen D, Grody, Wayne W

“…Arginase I (AI) has a critical function in mammalian liver as the final enzyme in the urea cycle responsible for the disposal of ammonia from protein…”
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Arginase deficiency with lethal neonatal expression: Evidence for the glutamine hypothesis of cerebral edema by Picker, Jonathan D., Puga, Ana C., Levy, Harvey L., Marsden, Deborah, Shih, Vivian E., DeGirolami, Umberto, Ligon, Keith L., Cederbaum, Stephen D., Kern, Rita M., Cox, Gerald F.

“…We describe a rare and lethal case of arginase deficiency in a 2-day-old female infant with encephalopathy and cerebral edema. The levels of glutamine and…”
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Arginase expression in mouse embryonic development by Yu, Hong, Iyer, Ramaswamy K., Yoo, Paul K., Kern, Rita M., Grody, Wayne W., Cederbaum, Stephen D.

“…We are using the model of the developing mouse embryo to elucidate the pattern of arginase expression in mammalian cells in normal animals and in arginase I…”
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Co-induction of Arginase and Nitric Oxide Synthase in Murine Macrophages Activated by Lipopolysaccharide by Wang, W.W., Jenkinson, C.P., Griscavage, J.M., Kern, R.M., Arabolos, N.S., Byrns, R.E., Cederbaum, S.D., Ignarro, L.J.

“…In view of studies showing that not only nitric oxide synthase (NOS) activity but arginase activity is induced in rodent macrophages by lipopolysaccharide…”
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Cloning and Characterization of the Mouse and Rat Type II Arginase Genes by Iyer, Ramaswamy K., Bando, Joanne M., Jenkinson, Christopher P., Vockley, Joseph G., Kim, Phillip S., Kern, Rita M., Cederbaum, Stephen D., Grody, Wayne W.

“…Two forms of arginase, both catalyzing the hydrolysis of arginine to ornithine and urea, are found in animals ranging from amphibians to mammals. In humans,…”
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Identification of mutations (D128G, H141L) in the liver arginase gene of patients with hyperargininemia by Vockley, J G, Tabor, D E, Kern, R M, Goodman, B K, Wissmann, P B, Kang, D S, Grody, W W, Cederbaum, S D

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Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme by GRODY, W. W, KERN, R. M, KLEIN, D, DODSON, A. E, WISSMAN, P. B, BARSKY, S. H, CEDERBAUM, S. D

“…Deficiency of liver arginase (AI) is characterized clinically by hyperargininemia, progressive mental impairment, growth retardation, spasticity, and periodic…”
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Subcellular location and differential antibody specificity of arginase in tissue culture and whole animals by Spector, E B, Jenkinson, C P, Grigor, M R, Kern, R M, Cederbaum, S D

“…Studies in man and other mammals have demonstrated the existence of two forms of arginase, a cytoplasmic form located primarily in liver and a mitochondrial…”
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Isolation of human liver arginase cDNA and demonstration of nonhomology between the two human arginase genes by Dizikes, G J, Grody, W W, Kern, R M, Cederbaum, S D

“…A human liver cDNA library was screened by colony hybridization with a rat liver arginase cDNA. The number of positive clones detected was in agreement with…”
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Molecular genetic study of human arginase deficiency by GRODY, W. W, KLEIN, D, CEDERBAUM, S. D, DODSON, A. E, KERN, R. M, WISSMAN, P. B, GOODMAN, B. K, BASSAND, P, MARESCAU, B, SOO-SANG KANG, LEONARD, J. V

“…We have explored the molecular pathology in 28 individuals homozygous or heterozygous for liver arginase deficiency (hyperargininemia) by a combination of…”
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Delivery of cytosolic liver arginase into the mitochondrial matrix space: a possible novel site for gene replacement therapy by Wissmann, P B, Goodman, B K, Vockley, J G, Kern, R M, Cederbaum, S D, Grody, W W

“…As a toxic metabolic byproduct in mammals, excess ammonia is converted into urea by a series of five enzymatic reactions in the liver that constitute the urea…”
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Differential expression of multiple forms of arginase in cultured cells by SPECTOR, E. B, KERN, R. M, HAGGERTY, D. F, CEDERBAUM, S. D

“…Arginase (EC 3.5.3.1), the final enzyme in the urea cycle, catalyzes the cleavage of arginine to orthinine and urea. At least two forms of this enzyme, AI and…”
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Loss of Function Mutations in Conserved Regions of the Human Arginase I Gene by Vockley, Joseph G., Goodman, Barbara K., Tabor, David E., Kern, Rita M., Jenkinson, Christopher P., Grody, Wayne W., Cederbaum, Stephen D.

“…We have utilized SSCP analysis to identify disease-causing mutations in a cohort with arginase deficiency. Each of the patient's mutations was reconstructedin…”
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