Search Results - "Kern, Michael André"
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Down‐regulation of tumor suppressor a kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms
Published in Hepatology (Baltimore, Md.) (01-12-2010)“…The A kinase anchor protein 12 (AKAP12) is a central mediator of protein kinase A and protein kinase C signaling. Although AKAP12 has been described to act as…”
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Heat Shock Protein 90-Sheltered Overexpression of Insulin-Like Growth Factor 1 Receptor Contributes to Malignancy of Thymic Epithelial Tumors
Published in Clinical cancer research (15-04-2011)“…The underlying molecular mechanisms of thymic epithelial malignancies (TEMs) are poorly understood. Consequently, there is a lack of efficacious targeted…”
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Targeting heat shock protein 90 with non‐quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma
Published in Hepatology (Baltimore, Md.) (01-07-2009)“…The inhibition of heat shock protein 90 (Hsp90) has emerged as a promising antineoplastic strategy in diverse human malignancies. Hsp90 has been predicted to…”
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4
Expression of angiotensin II receptor type 1 is reduced in advanced rat liver fibrosis
Published in Digestive diseases and sciences (01-08-2007)“…In this study, we assessed the hypothesis that the expression of angiotensin II receptor type 1 (AGTR1) in liver tissue changes with increasing fibrosis, which…”
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Differential expression of E‐prostanoid receptors in human hepatocellular carcinoma
Published in International journal of cancer (01-02-2008)“…Recent studies have shown that inhibition of cyclooxygenases (e.g. COX‐2) exerts antitumorigenic effects on hepatocellular carcinomas (HCCs), which are to a…”
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6
DMBT1 expression distinguishes anorectal from cutaneous melanoma
Published in Histopathology (01-01-2009)“…Aims: Anorectal melanoma (AM) forms a rare but highly malignant subset of mucosal melanoma with an extremely poor prognosis. Although AMs display histological…”
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Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice
Published in Carcinogenesis (New York) (01-07-2004)“…Cyclooxygenase (COX)-2 is expressed in hepatocellular carcinomas (HCCs) and HCC cell lines. COX-2 inhibition strongly suppresses growth of HCC cells in vitro…”
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Her2 overexpression is a rare event in anorectal melanoma
Published in Melanoma research (01-10-2010)“…Anorectal melanomas (AMs) are very rare and highly malignant tumors that are often diagnosed in advanced stages. After the differentiation between cutaneous…”
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Cyclooxygenase-2 (COX-2)--a therapeutic target in liver cancer?
Published in Current pharmaceutical design (01-11-2007)“…Targeting COX-2, a key-enzyme of the prostaglandin metabolism, for the treatment of cancer has been in the focus of researchers for about a decade. However,…”
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10
CONCENTRATIONS OF HEPATOCYTE GROWTH FACTOR IN CEREBROSPINAL FLUID UNDER NORMAL AND DIFFERENT PATHOLOGICAL CONDITIONS
Published in Cytokine (Philadelphia, Pa.) (07-05-2001)“…Hepatocyte growth factor (HGF) and its specific receptor, MET, are expressed in the developing and adult mammalian brain. Recent studies have shown a…”
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Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells
Published in Hepatology (Baltimore, Md.) (01-10-2002)“…Recent studies have shown increased levels of cyclooxygenase-2 (COX-2) in a variety of human malignancies, including hepatocellular carcinoma (HCC), but so far…”
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Precision Cut Tissue Slices of the Liver as Morphological Tool for Investigation of Apoptosis
Published in In vivo (Athens) (01-03-2005)“…Background: Apoptosis, programmed cell death, is involved in a broad range of pathological processes. Dysregulation of apoptosis plays a key role in the…”
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Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma
Published in Liver international (01-06-2006)“…: Cultures of precision‐cut tissue slices allow the investigation of substance effects on human tissues under in vivo‐like conditions over a limited time span…”
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14
Stage‐extension device for transmission light microscopes
Published in Journal of microscopy (Oxford) (01-09-2005)“…Summary For routine applications, more and more professional microscope users have removed the slide holders from their transmission light microscopes and…”
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510 Inhibition of cyclooxygenase-2 suppresses the growth of human hepatocellular carcinoma implants in vivo
Published in Hepatology (Baltimore, Md.) (2003)Get full text
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Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells
Published in Hepatology (Baltimore, Md.) (2002)“…Recent studies have shown increased levels of cyclooxygenase-2 (COX-2) in a variety of human malignancies, including hepatocellular carcinoma (HCC), but so far…”
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AMYOTROPHIC LATERAL SCLEROSIS: EVIDENCE FOR INTACT HEPATOCYTE GROWTH FACTOR/MET SIGNALLING AXIS
Published in Cytokine (Philadelphia, Pa.) (21-09-2001)“…Hepatocyte growth factor (HGF) is a secreted cytokine which is expressed in the central nervous system (CNS) together with its specific receptor MET. Since HGF…”
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18
Effect of the AT1-receptor antagonist candesartancilexetil on liver fibrosis in the rat bile duct occlusion model
Published in Gastroenterology (New York, N.Y. 1943) (01-04-2003)Get full text
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