Search Results - "Kern, Fredy"

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions by Tao, Thi-Phuong, Maschmeyer, Ilka, LeCluyse, Edward L, Rogers, Eda, Brandmair, Katrin, Gerlach, Silke, Przibilla, Julia, Kern, Fredy, Genies, Camille, Jacques, Carine, Najjar, Abdulkarim, Schepky, Andreas, Marx, Uwe, Kühnl, Jochen, Hewitt, Nicola J

“…All cosmetic ingredients registered in Europe must be evaluated for their safety using non-animal methods. Microphysiological systems (MPS) offer a more…”
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Conversions of tricyclic antidepressants and antipsychotics with selected P450s from Sorangium cellulosum So ce56 by Litzenburger, Martin, Kern, Fredy, Khatri, Yogan, Bernhardt, Rita

“…Human cytochromes P450 (P450s) play a major role in the biotransformation of drugs. The generated metabolites are important for pharmaceutical, medical, and…”
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Identification of a new plasmid-encoded cytochrome P450 CYP107DY1 from Bacillus megaterium with a catalytic activity towards mevastatin by Milhim, Mohammed, Putkaradze, Natalia, Abdulmughni, Ammar, Kern, Fredy, Hartz, Philip, Bernhardt, Rita

“…•Identification and characterization of new plasmid-encoded cytochrome P450 from Bacillus megaterium.•The new cytochrome P450 belongs to the CYP107 family and…”
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CYP267A1 and CYP267B1 from Sorangium cellulosum So ce56 are Highly Versatile Drug Metabolizers by Kern, Fredy, Khatri, Yogan, Litzenburger, Martin, Bernhardt, Rita

“…The guidelines of the Food and Drug Administration and International Conference on Harmonization have highlighted the importance of drug metabolites in…”
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Highly Efficient CYP167A1 (EpoK) dependent Epothilone B Formation and Production of 7-Ketone Epothilone D as a New Epothilone Derivative by Kern, Fredy, Dier, Tobias K. F., Khatri, Yogan, Ewen, Kerstin M., Jacquot, Jean-Pierre, Volmer, Dietrich A., Bernhardt, Rita

“…Since their discovery in the soil bacterium Sorangium cellulosum , epothilones have emerged as a valuable substance class with promising anti-tumor activity…”
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