Search Results - "Kern, David M."

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs by Kern, David M., Sorum, Ben, Mali, Sonali S., Hoel, Christopher M., Sridharan, Savitha, Remis, Jonathan P., Toso, Daniel B., Kotecha, Abhay, Bautista, Diana M., Brohawn, Stephen G.

“…SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy inhibition, inflammasome activation and apoptosis. 3a protein and anti-3a antibodies…”
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Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs by Kern, David M, Oh, SeCheol, Hite, Richard K, Brohawn, Stephen G

“…Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8…”
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Treatment patterns and comorbid burden of patients newly diagnosed with multiple sclerosis in the United States by Kern, David M, Cepeda, M Soledad

“…The treatment landscape for multiple sclerosis (MS) is quickly evolving. Understanding real-world treatment patterns of patients is necessary to identifying…”
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Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs by Reid, Michelle S, Kern, David M, Brohawn, Stephen Graf

“…Cation-chloride-cotransporters (CCCs) catalyze transport of Cl with K and/or Na across cellular membranes. CCCs play roles in cellular volume regulation,…”
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Treatment patterns and sequences of pharmacotherapy for patients diagnosed with depression in the United States: 2014 through 2019 by Kern, David M, Cepeda, M Soledad, Defalco, Frank, Etropolski, Mila

“…Understanding how patients are treated in the real-world is vital to identifying potential gaps in care. We describe the current pharmacologic treatment…”
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Structure of SARS-CoV-2 M protein in lipid nanodiscs by Dolan, Kimberly A, Dutta, Mandira, Kern, David M, Kotecha, Abhay, Voth, Gregory A, Brohawn, Stephen G

“…SARS-CoV-2 encodes four structural proteins incorporated into virions, spike (S), envelope (E), nucleocapsid (N), and membrane (M). M plays an essential role…”
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Treatment patterns of patients diagnosed with major depressive disorder and suicidal ideation or attempt: a U.S. population-based study utilizing real-world data by Kern, David M, Cepeda, M Soledad, Wiegand, Frank

“…There is a knowledge gap regarding the treatment patterns of patients with major depressive disorder (MDD) who experience suicidal ideation or a suicide…”
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Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8 by Ellman, Lauren M, Deicken, Raymond F, Vinogradov, Sophia, Kremen, William S, Poole, John H, Kern, David M, Tsai, Wei Yann, Schaefer, Catherine A, Brown, Alan S

“…Abstract Background Maternal infection during pregnancy has been repeatedly associated with increased risk for schizophrenia. Nevertheless, most viruses do not…”
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Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis by Schweizer, Nina, Ferrás, Cristina, Kern, David M, Logarinho, Elsa, Cheeseman, Iain M, Maiato, Helder

“…Tpr is a conserved nuclear pore complex (NPC) protein implicated in the spindle assembly checkpoint (SAC) by an unknown mechanism. Here, we show that Tpr is…”
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A mitotic SKAP isoform regulates spindle positioning at astral microtubule plus ends by Kern, David M, Nicholls, Peter K, Page, David C, Cheeseman, Iain M

“…The Astrin/SKAP complex plays important roles in mitotic chromosome alignment and centrosome integrity, but previous work found conflicting results for SKAP…”
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Treatment resistant depression in women with peripartum depression by Cepeda, M Soledad, Kern, David M, Nicholson, Susan

“…Peripartum depression is a leading cause of disease burden for women and yet there is little evidence as to how often peripartum depression does not respond to…”
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Association between prolactin increasing antipsychotic use and the risk of breast cancer: a retrospective observational cohort study in a United States Medicaid population by Kern, David M, Shoaibi, Azza, Shearer, David, Richarz, Ute, Killion, Leslie, Knight, R Karl

“…Results of retrospective studies examining the relationship between prolactin increasing antipsychotics and incident breast cancer have been inconsistent. This…”
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Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes by Gunasekar, Susheel K., Xie, Litao, Kumar, Ashutosh, Hong, Juan, Chheda, Pratik R., Kang, Chen, Kern, David M., My-Ta, Chau, Maurer, Joshua, Heebink, John, Gerber, Eva E., Grzesik, Wojciech J., Elliot-Hudson, Macaulay, Zhang, Yanhui, Key, Phillip, Kulkarni, Chaitanya A., Beals, Joseph W., Smith, Gordon I., Samuel, Isaac, Smith, Jessica K., Nau, Peter, Imai, Yumi, Sheldon, Ryan D., Taylor, Eric B., Lerner, Daniel J., Norris, Andrew W., Klein, Samuel, Brohawn, Stephen G., Kerns, Robert, Sah, Rajan

“…Type 2 diabetes is associated with insulin resistance, impaired pancreatic β-cell insulin secretion, and nonalcoholic fatty liver disease. Tissue-specific…”
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Suicide‐specific mortality among patients with treatment‐resistant major depressive disorder, major depressive disorder with prior suicidal ideation or suicide attempts, or major depressive disorder alone by Kern, David M., Canuso, Carla M., Daly, Ella, Johnson, Jonathan C., Fu, Dong Jing, Doherty, Teodora, Blauer‐Peterson, Cori, Cepeda, M. Soledad

“…Background The impact of treatment‐resistant depression (TRD) or prior suicidal ideation/suicide attempt (SI/SA) on mortality by suicide among patients with…”
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Incidence and Prevalence of Microvascular and Macrovascular Diseases and All-cause Mortality in Type 2 Diabetes Mellitus: A 10-year Study in a US Commercially Insured and Medicare Advantage Population by Visaria, Jay, PhD, MPH, Iyer, Neeraj N., PhD, Raval, Amit, PhD, Kong, Sheldon, PhD, Hobbs, Todd, MD, Bouchard, Jonathan, MS, RPh, Kern, David M., PhD, Willey, Vincent, PharmD, BCACP

“…AbstractPurposeThe relationship between type 2 diabetes mellitus (T2DM) and increased microvascular and macrovascular disease and mortality is well…”
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Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80 by Kern, David M, Monda, Julie K, Su, Kuan-Chung, Wilson-Kubalek, Elizabeth M, Cheeseman, Iain M

“…Chromosome segregation requires robust interactions between the macromolecular kinetochore structure and dynamic microtubule polymers. A key outstanding…”
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Treatment with TNF‐α inhibitors versus methotrexate and the association with dementia and Alzheimer's disease by Kern, David M., Lovestone, Simon, Cepeda, M. Soledad

“…Introduction Peripheral inhibition of tumor necrosis factor (TNF)‐α, outside of the central nervous system, may result in clinical improvement of Alzheimer's…”
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Differences between men and women in response to antiseizure medication use and the likelihood of developing treatment resistant epilepsy by Cepeda, M. Soledad, Teneralli, Rachel E., Kern, David M., Novak, Gerald

“…Objective The prevalence of epilepsy is slightly higher in women than in men and sensitivity to seizure stimuli differs between sexes. Some evidence suggests…”
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Update on prevalence of diagnosed systemic lupus erythematosus (SLE) by major health insurance types in the US in 2016 by Wang, Yiting, Hester, Laura L, Lofland, Jennifer, Rose, Shawn, Karyekar, Chetan S, Kern, David M, Blacketer, Margaret, Davis, Kourtney, Shields-Tuttle, Kimberly

“…To provide current estimates of the number of patients with prevalent systemic lupus erythematosus (SLE) by major health insurance types in the US and…”
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Asthma and Chronic Obstructive Pulmonary Disease Overlap Syndrome: Doubled Costs Compared with Patients with Asthma Alone by Gerhardsson de Verdier, Maria, MD, PhD, Andersson, Maria, PhD, Kern, David M., MS, Zhou, Siting, PhD, Tunceli, Ozgur, PhD

“…Abstract Background Patients with asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) have more rapid disease progression and more…”
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