Search Results - "Kern, D."

Supervised Machine Learning for Population Genetics: A New Paradigm by Schrider, Daniel R., Kern, Andrew D.

“…As population genomic datasets grow in size, researchers are faced with the daunting task of making sense of a flood of information. To keep pace with this…”
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The Neutral Theory in Light of Natural Selection by Kern, Andrew D, Hahn, Matthew W

“…In this perspective, we evaluate the explanatory power of the neutral theory of molecular evolution, 50 years after its introduction by Kimura. We argue that…”
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Soft Sweeps Are the Dominant Mode of Adaptation in the Human Genome by Schrider, Daniel R, Kern, Andrew D

“…The degree to which adaptation in recent human evolution shapes genetic variation remains controversial. This is in part due to the limited evidence in humans…”
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A quantitative genetic model of background selection in humans by Buffalo, Vince, Kern, Andrew D

“…Across the human genome, there are large-scale fluctuations in genetic diversity caused by the indirect effects of selection. This "linked selection signal"…”
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S/HIC: Robust Identification of Soft and Hard Sweeps Using Machine Learning by Schrider, Daniel R, Kern, Andrew D

“…Detecting the targets of adaptive natural selection from whole genome sequencing data is a central problem for population genetics. However, to date most…”
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Effects of Linked Selective Sweeps on Demographic Inference and Model Selection by Schrider, Daniel R, Shanku, Alexander G, Kern, Andrew D

“…The availability of large-scale population genomic sequence data has resulted in an explosion in efforts to infer the demographic histories of natural…”
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A retrospective study of the 2012-2016 California drought and its impacts on the power sector by Kern, Jordan D, Su, Yufei, Hill, Joy

“…Over the period 2012-2016, the state of California in the United States (U.S.) experienced a drought considered to be one of the worst in state history…”
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diploS/HIC: An Updated Approach to Classifying Selective Sweeps by Kern, Andrew D, Schrider, Daniel R

“…Identifying selective sweeps in populations that have complex demographic histories remains a difficult problem in population genetics. We previously…”
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Supervised machine learning reveals introgressed loci in the genomes of Drosophila simulans and D. sechellia by Schrider, Daniel R, Ayroles, Julien, Matute, Daniel R, Kern, Andrew D

“…Hybridization and gene flow between species appears to be common. Even though it is clear that hybridization is widespread across all surveyed taxonomic…”
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Colorectal Cancer Knowledge and Awareness Among University Students in a Caribbean Territory: a Cross-sectional Study by Rocke, Kern D.

“…Introduction The burden of colorectal cancer (CRC) has been on the rise globally over the last decade. Several studies point to the fact that there is a lack…”
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The Impact of a Ketogenic Dietary Intervention on the Quality of Life of Stage II and III Cancer Patients: A Randomized Controlled Trial in the Caribbean by Augustus, Eden, Granderson, Isabella, Rocke, Kern D.

“…This study sought to determine the impact of a ketogenic dietary intervention on the quality of life of stage II and III cancer patients. A randomized…”
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Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks by Hahn, Matthew W, Kern, Andrew D

“…Most proteins do not evolve in isolation, but as components of complex genetic networks. Therefore, a protein's position in a network may indicate how central…”
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disperseNN2: a neural network for estimating dispersal distance from georeferenced polymorphism data by Smith, Chris C R, Kern, Andrew D

“…Spatial genetic variation is shaped in part by an organism's dispersal ability. We present a deep learning tool, disperseNN2, for estimating the mean…”
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Predicting geographic location from genetic variation with deep neural networks by Battey, C J, Ralph, Peter L, Kern, Andrew D

“…Most organisms are more closely related to nearby than distant members of their species, creating spatial autocorrelations in genetic data. This allows us to…”
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Biocompatibility of poly(ethylene glycol)-based hydrogels in the brain: An analysis of the glial response across space and time by Bjugstad, K. B., Lampe, K., Kern, D. S., Mahoney, M.

“…Poly(ethylene glycol) or PEG‐based hydrogels provide a useful methodology for tissue engineering and the controlled‐release of drugs within the central nervous…”
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Competitive balance within CONCACAF: a longitudinal and comparative descriptive review of the seasons 2002/2003-2017/2018 by Rocke, Kern D.

“…Rationale/Purpose: This article examines the trend in competitive balance and its association with end-of-year FIFA rankings among CONCACAF football…”
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The Effect of Common Inversion Polymorphisms In(2L)t and In(3R)Mo on Patterns of Transcriptional Variation in Drosophila melanogaster by Lavington, Erik, Kern, Andrew D

“…Chromosomal inversions are a ubiquitous feature of genetic variation. Theoretical models describe several mechanisms by which inversions can drive adaptation…”
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Using ancient protein kinases to unravel a modern cancer drug's mechanism by Wilson, C., Agafonov, R. V., Hoemberger, M., Kutter, S., Zorba, A., Halpin, J., Buosi, V., Otten, R., Waterman, D., Theobald, D. L., Kern, D.

“…Macromolecular function is rooted in energy landscapes, where sequence determines not a single structure but an ensemble of conformations. Hence, evolution…”
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Preexposure Prophylaxis in Latin America and the Caribbean-The Barbados Experience by Augustus, Eden Hope, George, Clemon, Rocke, Kern D

“…This study explored oral pre-exposure prophylaxis (PrEP) awareness, and sexual behavior of gay, bisexual, and other men who have sex with men (gbMSM) in…”
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Parallel substrate supply and pH stabilization for optimal screening of E. coli with the membrane-based fed-batch shake flask by Philip, P, Kern, D, Goldmanns, J, Seiler, F, Schulte, A, Habicher, T, Büchs, J

“…Screening in the fed-batch operation mode is essential for biological cultivations facing challenges as oxygen limitation, osmotic inhibition, catabolite…”
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