Search Results - "Kern, Brent"

Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody by Al-Khami, Amir A., Youssef, Sawsan, Abdiche, Yasmina, Nguyen, HoangKim, Chou, Joyce, Kimberlin, Christopher R., Chin, Sherman M., Kamperschroer, Cris, Jessen, Bart, Kern, Brent, Budimir, Natalija, Dillon, Christopher P., Xu, Allison, Clark, Jerry D., Chou, Jeffrey, Kraynov, Eugenia, Rajpal, Arvind, Lin, John C., Salek-Ardakani, Shahram

“…Abstract Development of antagonistic mAbs that specifically target the immune checkpoint receptor, programmed cell death protein-1 (PD-1), is of great interest…”
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Receptor occupancy and blocking of STAT5 signaling by an anti-IL-7 receptor [alpha] antibody in cynomolgus monkeys by Kern, Brent, Li, Wenlin, Bono, Christine, Lee, Li-Fen, Kraynov, Eugenia

“…Background Interleukin-7 receptor [alpha] (IL-7R[alpha]) is associated with autoimmune disease. Blocking its activation by interleukin-7 (IL-7) with a…”
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An Interpretative Phenomenological Analysis of the Professional Identity Development of United States Trained Counselors in Trinidad by Pereira, Brent Kern

“…This study explored the professional identity of counselors who were trained in the United States and practice in Trinidad. Interpretative phenomenological…”
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Receptor occupancy and blocking of STAT5 signaling by an anti-IL-7 receptor α antibody in cynomolgus monkeys by Kern, Brent, Li, Wenlin, Bono, Christine, Lee, Li-Fen, Kraynov, Eugenia

“…Background Interleukin‐7 receptor α (IL‐7Rα) is associated with autoimmune disease. Blocking its activation by interleukin‐7 (IL‐7) with a therapeutic…”
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144: Receptor occupancy and internalization of an anti-IL-7 receptor antibody by Kern, Brent, Kraynov, Eugenia, Lee, Li-Fen, Ray, Chad

“…In vitro (or ex vivo) quantification of cellular parameters is often employed to inform systems models that define the relationship between drug exposure and…”
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144 by Kern, Brent, Kraynov, Eugenia, Lee, Li-Fen, Ray, Chad

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Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties by Carnahan, Josette, Wang, Paul, Kendall, Richard, Chen, Ching, Hu, Sylvia, Boone, Tom, Juan, Todd, Talvenheimo, Jane, Montestruque, Silvia, Sun, Jilin, Elliott, Gary, Thomas, John, Ferbas, John, Kern, Brent, Briddell, Robert, Leonard, John P, Cesano, Alessandra

“…Epratuzumab is a novel humanized antihuman CD22 IgG1 antibody that has recently shown promising clinical activity, both as a single agent and in combination…”
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A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans by Molineux, Graham, Kinstler, Olaf, Briddell, Bob, Hartley, Cynthia, McElroy, Patricia, Kerzic, Patrick, Sutherland, Weston, Stoney, Greg, Kern, Brent, Fletcher, Frederick A., Cohen, Art, Korach, Elliot, Ulich, Tom, McNiece, Ian, Lockbaum, Pamela, Miller-Messana, Mary Ann, Gardner, Sheila, Hunt, Thomas, Schwab, Gisela

“…Granulocyte colony-stimulating factor (G-CSF) has proven effective in the prophylaxis of chemotherapy-induced neutropenia and as a mobilizer of peripheral…”
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A method for the determination of the number of reticulated platelets from whole blood by Kern, Brent, Molineux, Graham, Briddell, Robert

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Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22 by Josette Carnahan, Paul Wang, Richard Kendall, Ching Chen, Sylvia Hu, Tom Boone, Todd Juan, Jane Talvenheimo, Silvia Montestruque, Jilin Sun, Gary Elliott, John Thomas, John Ferbas, Brent Kern, Robert Briddell, John P. Leonard, Alessandra Cesano

“…Purpose: Epratuzumab is a novel humanized antihuman CD22 IgG1 antibody that has recently shown promising clinical activity, both as a single agent and in…”
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Minimization of CD34+ cell enumeration variability using the ProCOUNT standardized methodology by McNiece, I, Kern, B, Zilm, K, Brunaud, C, Dziem, G, Briddell, R

“…The dose of cells expressing the surface antigen CD34 (CD34+) has been shown to be a reliable predictor of the time to engraftment following transplantation of…”
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Purification of CD34+ cells is essential for optimal ex vivo expansion of umbilical cord blood cells by Briddell, R A, Kern, B P, Zilm, K L, Stoney, G B, McNiece, I K

“…Allogeneic umbilical cord blood (UCB) cells have recently been used for transplantation following high-dose chemotherapy. However, the numbers of total cells,…”
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CD34+ cell selection from frozen cord blood products using the Isolex 300i and CliniMACS CD34 selection devices by McNiece, I K, Stoney, G B, Kern, B P, Briddell, R A

“…Ex vivo expansion of cord blood (CB) cells requires CD34+ cell selection before expansion to obtain optimal numbers of progenitor cells. As a preliminary step…”
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