Search Results - "Kermorgant, S"

476: Understanding and targeting PI3K pathway downstream of Met oncogenic mutant by Hervieu, A, Joffre, C, Leung, Z, Kermorgant, S

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c-Met Signalling: Spatio-Temporal Decisions by Kermorgant, S., Parker, P.J.

“…The spatial control of signalling events is critical in determining the outcome of a cellular response. Recent studies on the signal output from the growth…”
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Comment on ‘High MET expression is an adverse prognostic factor in patients with triple-negative breast cancer’ by Ho-Yen, C, Bowen, R L, Kermorgant, S, Jones, J L

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Leptin secretion and leptin receptor in the human stomach by Sobhani, I, Bado, A, Vissuzaine, C, Buyse, M, Kermorgant, S, Laigneau, J-P, Attoub, S, Lehy, T, Henin, D, Mignon, M, Lewin, M J M

“…BACKGROUND AND AIM The circulating peptide leptin produced by fat cells acts on central receptors to control food intake and body weight homeostasis. Contrary…”
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454 c-Met endosomal signalling and breast cancer cell migration by Barrow, R, Menard, L, Kermorgant, S

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68PC-met mediates invasion and chemotherapy resistance in high grade serous ovarian cancer by Wood, G E, Lockley, M, Kermorgant, S

“…Abstract Background High grade serous ovarian cancer (HGSOC) is characterised by progressive chemo-resistance. Survival in advanced HGSOC is poor and new…”
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C-met mediates invasion and chemotherapy resistance in high grade serous ovarian cancer by Wood, G.E., Lockley, M., Kermorgant, S.

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Integrin-protein kinase C relationships by Ivaska, J, Kermorgant, S, Whelan, R, Parsons, M, Ng, T, Parker, P J

“…The integrins have an ability to interact with extracellular matrix proteins to confer adhesive and motile properties on cells. The means by which these…”
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Developmental expression and functionality of hepatocyte growth factor and c-Met in human fetal digestive tissues by Kermorgant, S, Walker, F, Hormi, K, Dessirier, V, Lewin, MJ, Lehy, T

“…BACKGROUND & AIMS: Hepatocyte growth factor (HGF) and its receptor c- Met are presumed to play a morphogenic role during embryogenesis. The possible…”
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HGF upregulates and modifies subcellular distribution of proteins in colon cancer cell enterocytic differentiation by Kermorgant, S, Dessirier, V, Lewin, M J, Lehy, T

“…Hepatocyte growth factor (HGF) and its receptor, c-Met, are involved in cell transformation. To study their role in intestinal cell differentiation, we used…”
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Understanding and targeting Met signalling in bladder cancer by Badreldin, W., Powles, T., Menard, L., Ho-Yen, C., Kermorgant, S.

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Transforming Growth Factor-α and Epidermal Growth Factor Receptor in Colonic Mucosa in Active and Inactive Inflammatory Bowel Disease by Hormi, Khadija, Cadiot, Guillaume, Kermorgant, Stéphanie, Dessirier, Valérie, Le Romancer, Muriel, Lewin, Miguel J. M., Mignon, Michel, Lehy, Thérése

“…Abstract Transforming growth factor-α (TGF-α) is overexpressed in colonic carcinomas and promotes mucosal wound healing. It may be implicated in chronic…”
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PKC controls HGF-dependent c-Met traffic, signalling and cell migration by Kermorgant, Stéphanie, Zicha, Daniel, Parker, Peter J

“…The growth factor/receptor pair HGF/c‐Met exerts control on proliferation, morphogenesis and motility, and through overexpression and mutation is implicated in…”
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MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanised HGF knock-in mice by Fernandes, Marie, Hoggard, Brynna, Jamme, Philippe, Paget, Sonia, Truong, Marie-José, Grégoire, Valérie, Vinchent, Audrey, Descarpentries, Clotilde, Morabito, Angela, Stanislovas, Justas, Farage, Enoir, Meneboo, Jean-Pascal, Sebda, Shéhérazade, Bouchekioua-Bouzaghou, Katia, Nollet, Marie, Humez, Sarah, Perera, Timothy, Fromme, Paul, Grumolato, Luca, Figeac, Martin, Copin, Marie-Christine, Tulasne, David, Cortot, Alexis B, Kermorgant, Stéphanie, Kherrouche, Zoulika

“…Exon skipping mutations of the MET receptor tyrosine kinase (METex14), increasingly reported in cancers, occur in 3-4% of non-small-cell lung cancer (NSCLC)…”
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The stomach is a source of leptin by Lewin, Miguel. J. M, Bado, André, Levasseur, Sandrine, Attoub, Samir, Kermorgant, Stéphanie, Laigneau, Jean-Pierre, Bortoluzzi, Marie-Noëlle, Moizo, Laurent, Lehy, Thérèse, Guerre-Millo, Michèle, Le Marchand-Brustel, Yannick

“…The circulating peptide leptin, which is the product of the ob gene, provides feedback information on the size of fat stores to central Ob receptors, that…”
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Glycine-Extended Gastrin Promotes the Invasiveness of Human Colon Cancer Cells by Kermorgant, Stéphanie, Lehy, Thérèse

“…Colorectal cancers express significant amounts of immature glycine-extended gastrin (G-Gly) and G-Gly is able to stimulate cell proliferation in colonic cell…”
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Protein Kinase C Controls Microtubule-based Traffic but Not Proteasomal Degradation of c-Met by Kermorgant, Stéphanie, Zicha, Daniel, Parker, Peter J.

“…Upon hepatocyte growth factor stimulation, its receptor c-Met is rapidly internalized via clathrin-coated vesicles and traffics through an early endosomal…”
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Leptin and Ob-Rb Receptor Isoform in the Human Digestive Tract during Fetal Development by Aparicio, Thomas, Kermorgant, Stéphanie, Darmoul, Dalila, Guilmeau, Sandra, Hormi, Khadija, Mahieu-Caputo, Dominique, Lehy, Thérèse

“…Context: Leptin, partially produced by the stomach, is a hormone involved in energy balance and regulation of food intake. It also regulates some digestive…”
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Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction. Evidence for PI3 kinase and PKC involvement by Kermorgant, Stéphanie, Aparicio, Thomas, Dessirier, Valérie, Lewin, Miguel J.M., Lehy, Thérèse

“…Tumour progression to the metastatic phenotype is mainly dependent on tumour cell invasiveness. Cell migration is a crucial step in this process. Here we…”
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Hepatocyte growth factor and c-Met in cervical intraepithelial neoplasia: Overexpression of proteins associated with oncogenic human papillomavirus and human immunodeficiency virus by WALKER, Francine, KERMORGANT, Stéphanie, DARAI, Emile, MADELENAT, Patrick, CREMIEUX, Anne Claude, HENIN, Dominique, LEHY, Thérèse

“…High prevalence of squamous cervical intraepithelial neoplasia (CIN) linked to oncogenic human papillomavirus (HPV) exits in HIV-infected women. Hepatocyte…”
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