Search Results - "Kerlin, Roy L"

Spontaneous and Age-Related Testicular Findings in Beagle Dogs by Goedken, Michael J., Kerlin, Roy L., Morton, Daniel

“…This study was conducted to characterize spontaneous testicular and epididymal microscopic findings in eighty control beagle dogs from toxicity studies…”
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Regulatory Forum Opinon Piece: Raw Data in Pathology—Always a Conundrum, Often a Controversy by Kerlin, Roy L.

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Is It Adverse, Nonadverse, Adaptive, or Artifact? by Pandiri, Arun R., Kerlin, Roy L., Mann, Peter C., Everds, Nancy E., Sharma, Alok K., Myers, L. Peyton, Steinbach, Thomas J.

“…One of the principal challenges facing a toxicologic pathologist is to determine and differentiate a true adverse effect from a nonadverse or an adaptive…”
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The PPARα Agonists Fenofibrate and CP-778875 Cause Increased β-Oxidation, Leading to Oxidative Injury in Skeletal and Cardiac Muscle in the Rat by Pettersen, John C., Pruimboom-Brees, Ingrid, Francone, Omar L., Amacher, David E., Boldt, Sherri E., Kerlin, Roy L., Ballinger, William E.

“…Weak peroxisome proliferator–activated receptor (PPAR) α agonists (fibrates) are used to treat dyslipidemia. This study compared the effects of the potent and…”
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Regulatory Forum Opinion Piece: Pathology Peer Review—Dilemmas of Documentation by Kerlin, Roy L., Schafer, Kenneth A.

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The Development of Subcutaneous Sarcomas in Rodents Exposed to Peroxisome Proliferators Agonists: Hypothetical Mechanisms of Action and De-Risking Attitude by Pruimboom-Brees, Ingrid M., Francone, Omar, Pettersen, John C., Kerlin, Roy L., Will, Yvonne, Amacher, David E., Boucher, Germaine G., Morton, Daniel

“…Peroxisome proliferator-activated receptors (PPARs) represent therapeutic targets for the management of type 2 diabetes mellitus and dyslipidemia. Rodent…”
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Neurotoxic Effects of Zoniporide: A Selective Inhibitor of the Na+/H+ Exchanger Isoform 1 by Pettersen, John C., Chouinard, Luc, Kerlin, Roy L., Groom, Simon N., Botts, Suzanne, Arezzo, Joseph C., Boucher, Mary A., Frazier, Donald E., Buchholz, Allan R.

“…Zoniporide, an inhibitor of the Na+-H+ exchanger-1, was administered by continuous intravenous infusion to rats and dogs for up to 1 month. In 1-month studies,…”
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Cystic degeneration/spongiosis hepatis in rats by KARBE, Eberhard, KERLIN, Roy L

“…Cystic degeneration/spongiosis hepatis in rats has been proposed to be a preneoplastic and/or neoplastic lesion by some authors, because of its proliferative…”
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Response to Comments on E. Karbe and R. L. Kerlin (2002). Cystic Degeneration/Spongiosis Hepatis (Toxicol Pathol 30 (2), 216—227) by Kerlin, Roy L., Karbe, Eberhard

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Review Article: Cystic Degeneration/Spongiosis Hepatis in Rats by Karbe, Eberhard, Kerlin, Roy L.

“…Cystic degeneration/spongiosis hepatis in rats has been proposed to be a preneoplastic and/or neoplastic lesion by some authors, because of its proliferative…”
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Using Laser Scanning Cytometry to Measure PPAR-Mediated Peroxisome Proliferation and β Oxidation by Pruimboom-Brees, Ingrid M., Brees, Dominique J. J. E., Shen, Amy C., Keener, Mary, Francone, Omar, Amacher, David E., Loy, James K., Kerlin, Roy L.

“…Laser scanning cytometry (LSC) is a new technology that combines the properties and advantages of flow cytometry (FC) and immunohistochemistry (IHC), thus…”
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Histologic Lesions in Cynomolgus Monkeys (Macaca fascicularis) Naturally Infected with Simian Retrovirus Type D: Comparison of Seropositive, Virus-Positive, and Uninfected Animals by Guzman, Roberto E., Kerlin, Roy L., Zimmerman, Thomas E.

“…Simian retrovirus (SRV) type D is a common cause of simian acquired immunodeficiency syndrome (SAIDS), a usually fatal immunosuppressive disease of macaques…”
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牛末梢血リンパ球におけるヒスタミンレセプター by 猪熊, 壽, L., Kerlin Roy, H., Kemp David, Peter, Willadsen

“…ロゼット法, セファローズビーズ法及び免疫蛍光法の3つの方法により牛末梢血リンパ球(PBL)におけるヒスタミンレセプター(HR)を検出した. 免疫蛍光法は他の2つの方法に比べてより安定的で定量的な方法と考えられた. 本法により, PBL, 末梢血B細胞分画及び末梢血T細胞分画はそれぞれ18.4%, 52.8%,…”
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Is it adverse, non-adverse, adaptive or artifact? by Pandiri, Arun R., Kerlin, Roy L., Mann, Peter C., Everds, Nancy E., Sharma, Alok K., Myers, L. Peyton, Steinbach, Thomas J.

“…One of the principal challenges facing a toxicologic pathologist is to determine and differentiate a true adverse effect from a non-adverse or an adaptive…”
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Commentary: A View on Discovery Pathology by Burkhardt, John E., Floyd, Eugenia, Kerlin, Roy L., Adler, Rick R., Ochoa, Ricardo, Reynolds, Jack A.

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Cutaneous T-cell lymphoma with Sezary syndrome in a dog by Foster, A.P. (University of Bristol, Langford, Somerset, UK.), Evans, E, Kerlin, R.L, Vail, D.M

“…An 8‐year‐old female spayed Cocker Spaniel mix breed dog was presented with generalized erythroderma, scaling and alopecia. Radiographs of the thorax…”
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Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip by Rosenbaum, M R, Kerlin, R L

“…Erythema multiforme major and disseminated intravascular coagulation developed in a dog 24 hours after exposure to a d-limonene-based insecticidal dip…”
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A poorly differentiated germ cell tumor (seminoma) in a Long Evans rat by Kerlin, R L, Roesler, A R, Jakowski, A B, Boucher, G G, Krull, D L, Appel, W H

“…A large neoplasm that replaced 1 testis of a Long Evans Rat was noted at the final necropsy of a dietary 2-yr study. By light microscopy, the morphological…”
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Histamine receptors on bovine peripheral blood lymphocytes by Inokuma, H. (Japan. Ministry of Agriculture, Forestry and Fisheries, Tokyo. Animal Industry Bureau), Kerlin, R.L, Kemp, D.H, Willadsen, P

“…Histamine receptors on bovine peripheral blood lymphocytes (PBL) were detected by three different methods: a rosetting technique, binding to histamine-bearing…”
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Neurotoxic Effects of Zoniporide: A Selective Inhibitor of the Na super(+)/H super(+) Exchanger Isoform 1 by Pettersen, John C, Chouinard, Luc, Kerlin, Roy L, Groom, Simon N, Botts, Suzanne, Arezzo, Joseph C, Boucher, Mary A, Frazier, Donald E, Buchholz, Allan R

“…Zoniporide, an inhibitor of the Na super(+)-H super(+) exchanger-1, was administered by continuous intravenous infusion to rats and dogs for up to 1 month. In…”
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