Search Results - "Kerlin, Bryce"

Epidemiology and Pathophysiology of Nephrotic Syndrome–Associated Thromboembolic Disease by Kerlin, Bryce A, Ayoob, Rose, Smoyer, William E

“…After infections, thromboembolism is considered by many experts to be the most significant life-threatening complication of nephrotic syndrome. The purpose of…”
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The emerging role of coagulation proteases in kidney disease by Madhusudhan, Thati, Kerlin, Bryce A., Isermann, Berend

“…Key Points In addition to their pivotal and well-established functions in haemostasis, coagulation regulators and receptors mediate non-haemostatic functions…”
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An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo by Li, Bin, Luo, Xiao, Deng, Binbin, Wang, Junfeng, McComb, David W, Shi, Yimin, Gaensler, Karin M. L, Tan, Xu, Dunn, Amy L, Kerlin, Bryce A, Dong, Yizhou

“…Systemic delivery of mRNA-based therapeutics remains a challenging issue for preclinical and clinical studies. Here, we describe new lipid-like nanoparticles…”
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Pediatric arterial thrombosis: A single‐institution cohort study of patient characteristics and thrombosis outcomes by Abdelghani, Eman, Agarwal, Shreya, Stanek, Joseph, Sankar, Amanda, Kerlin, Bryce A., Rodriguez, Vilmarie

“…Background Arterial thrombosis (AT) is an increasingly recognized complication in pediatrics. Consensus clinical practice guidelines suggest immediate removal…”
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Current and future management of pediatric venous thromboembolism by Kerlin, Bryce A.

“…Venous thromboembolism (VTE) is an increasingly common complication encountered in tertiary care pediatric settings. The purpose of this review is to summarize…”
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Venous thromboembolism in pediatric nephrotic syndrome by Kerlin, Bryce A., Haworth, Kellie, Smoyer, William E.

“…Childhood nephrotic syndrome (NS) is one of the most common pediatric kidney diseases, with an incidence of 2–7 per 100,000. Venous thromboembolism (VTE) is…”
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Sex dimorphisms in coagulation: Implications in trauma‐induced coagulopathy and trauma resuscitation by Coleman, Julia R., Gumina, Richard, Hund, Thomas, Cohen, Mitchell, Neal, Matthew D., Townsend, Kristy, Kerlin, Bryce A.

“…Trauma‐induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the…”
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Pediatric venous thromboembolism in the United States: A tertiary care complication of chronic diseases by Setty, Bhuvana A., O'Brien, Sarah H., Kerlin, Bryce A.

“…Background Pediatric venous thromboembolism (VTE) is an increasingly common problem. We hypothesized that VTE occurs most commonly in tertiary care settings…”
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Thrombin-Induced Podocyte Injury Is Protease-Activated Receptor Dependent by Sharma, Ruchika, Waller, Amanda P, Agrawal, Shipra, Wolfgang, Katelyn J, Luu, Hiep, Shahzad, Khurrum, Isermann, Berend, Smoyer, William E, Nieman, Marvin T, Kerlin, Bryce A

“…Nephrotic syndrome is characterized by massive proteinuria and injury of specialized glomerular epithelial cells called podocytes. Studies have shown that,…”
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Decreased Bleeding Rates in Patients with Hemophilia A Switching from Standard-Half-Life FVIII to BAY 94-9027 Prophylaxis by Mancuso, Maria Elisa, Reding, Mark T, Negrier, Claude, Kerlin, Bryce A, Rangarajan, Savita, Simpson, Mindy L

“…BAY 94-9027 (damoctocog alfa pegol, Jivi) is an extended-half-life recombinant factor VIII (rFVIII) shown to be well-tolerated and efficacious in bleeding…”
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Protease‐activated receptors: An illustrated review by Han, Xu, Nieman, Marvin T., Kerlin, Bryce A.

“…Proteases are important regulators of cell behavior, survival, and apoptosis. They communicate to cells directly through a special class of G‐protein–coupled…”
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Prognostic Value of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Predicting Venous Thromboembolism in Children With Lymphoma by Beall, Maren, Deep, Kyra, Tram, Nguyen K., Nabavinia, Mahboubeh, Janse, Sarah A., Chou, Ting-Heng, Hardisky, Dariya, Bobbey, Adam J., Kerlin, Bryce A., Audino, Anthony N., Stacy, Mitchel R.

“…Positron emission tomography (PET)/computed tomography (CT) imaging can detect changes in arterial inflammation, but has not been used to evaluate…”
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Epidemiology and Risk Factors for Thromboembolic Complications of Childhood Nephrotic Syndrome: A Midwest Pediatric Nephrology Consortium (MWPNC) Study by Kerlin, Bryce A., MD, Blatt, Neal B., MD, Fuh, Beng, MD, Zhao, Shuang, Lehman, Amy, PhD, Blanchong, Carol, MD, Mahan, John D., MD, Smoyer, William E., MD

“…Objectives To identify clinical variables predictive of the risk of thromboembolism (TE), and to confirm the incidence of TE in primary and secondary childhood…”
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Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration by Byrnes, James R, Lee, Taek, Sharaby, Sherif, Campbell, Robert A, Dobson, Dre'Von A, Holle, Lori A, Luo, Michelle, Kangro, Kadri, Homeister, Jonathon W, Aleman, Maria M, Luyendyk, James P, Kerlin, Bryce A, Dumond, Julie B, Wolberg, Alisa S

“…Transglutaminase factor XIII (FXIII) is essential for hemostasis, wound healing, and pregnancy maintenance. Plasma FXIII is composed of A and B subunit dimers…”
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Exploring the Role of Antithrombin in Nephrotic Syndrome-Associated Hypercoagulopathy: A Multi-Cohort Study and Meta-Analysis by Abdelghani, Eman, Waller, Amanda P, Wolfgang, Katelyn J, Stanek, Joseph R, Parikh, Samir V, Rovin, Brad H, Smoyer, William E, Kerlin, Bryce A

“…Nephrotic syndrome is associated with an acquired hypercoagulopathy that is thought to drive its predisposition for venous thromboembolism. Previous studies…”
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Use of electronic self‐administered bleeding assessment tool in diagnosis of paediatric bleeding disorders by Kaur, Dominder, Kerlin, Bryce A., Stanek, Joseph R., O'Brien, Sarah H.

“…Introduction In the era of electronic medical records, pen‐and‐paper‐based physician‐administered bleeding assessment tools (BAT) remain under‐utilized in the…”
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Moderate-intensity aerobic exercise vs desmopressin in adolescent males with mild hemophilia A: a randomized trial by Kumar, Riten, Dunn, Amy L., Schneiderman, Jane E., Gonzales, Anne, Bouskill, Vanessa, Widener, Pamela, Stanek, Joseph, Pluthero, Fred G., Waller, Amanda, Tarango, Cristina, Ahuja, Sanjay, Kerlin, Bryce A., Kahr, Walter H.A., Rand, Margaret L., Lillicrap, David, Carcao, Manuel

“…Persons with mild hemophilia A (HA) may use intranasal desmopressin prior to sports participation. Desmopressin is expensive and can cause vomiting, headache,…”
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State of the art in factor XIII laboratory assessment by Durda, Michael A., Wolberg, Alisa S., Kerlin, Bryce A.

“…Factor XIII, a heterotetrameric proenzyme, is converted to an activated transglutaminase by thrombin and calcium in the final phases of coagulation. Factor…”
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AKI in Children Hospitalized with Nephrotic Syndrome by Rheault, Michelle N, Zhang, Lei, Selewski, David T, Kallash, Mahmoud, Tran, Cheryl L, Seamon, Meredith, Katsoufis, Chryso, Ashoor, Isa, Hernandez, Joel, Supe-Markovina, Katarina, D'Alessandri-Silva, Cynthia, DeJesus-Gonzalez, Nilka, Vasylyeva, Tetyana L, Formeck, Cassandra, Woll, Christopher, Gbadegesin, Rasheed, Geier, Pavel, Devarajan, Prasad, Carpenter, Shannon L, Kerlin, Bryce A, Smoyer, William E

“…Children with nephrotic syndrome can develop life-threatening complications, including infection and thrombosis. While AKI is associated with adverse outcomes…”
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Treatment-Related Outcomes in Paget–Schroetter Syndrome—A Cross-Sectional Investigation by Kumar, Riten, Harsh, Katherine, Saini, Surbhi, O'Brien, Sarah H., Stanek, Joseph, Warren, Patrick, Giver, Jean, Go, Michael R., Kerlin, Bryce A.

“…To investigate treatment-related outcomes, namely radiological clot resolution, post-thrombotic syndrome (PTS), and health related quality-of-life (HRQoL)…”
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