Search Results - "Kerle, Anna"

Modeling of the human interleukin 12:receptor complex allows to engineer attenuated cytokine variants by Liebl, Korbinian, Aschenbrenner, Isabel, Schiller, Lisa, Kerle, Anna, Protzer, Ulrike, Feige, Matthias J.

“…Interleukin 12 (IL-12) plays major roles in immune defense against intracellular pathogens. By activating T cells and increasing antigen presentation, it is…”
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Assembly-dependent Structure Formation Shapes Human Interleukin-23 versus Interleukin-12 Secretion by Aschenbrenner, Isabel, Siebenmorgen, Till, Lopez, Abraham, Parr, Marina, Ruckgaber, Philipp, Kerle, Anna, Rührnößl, Florian, Catici, Dragana, Haslbeck, Martin, Frishman, Dmitrij, Sattler, Michael, Zacharias, Martin, Feige, Matthias J.

“…[Display omitted] •Subunit competition influences the secretion of heterodimeric cytokines.•Rational engineering enabled the design of a folding-competent…”
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Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions by Hildenbrand, Karen, Bohnacker, Sina, Menon, Priyanka Rajeev, Kerle, Anna, Prodjinotho, Ulrich F., Hartung, Franziska, Strasser, Patrick C., Catici, Dragana A. M., Rührnößl, Florian, Haslbeck, Martin, Schumann, Kathrin, Müller, Stephanie I., da Costa, Clarissa Prazeres, Esser-von Bieren, Julia, Feige, Matthias J.

“…Interleukins are secreted proteins that regulate immune responses. Among these, the interleukin 12 (IL-12) family holds a central position in inflammatory and…”
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