Search Results - "Kerkmeijer, Linda"

Focal Boost to the Intraprostatic Tumor in External Beam Radiotherapy for Patients With Localized Prostate Cancer: Results From the FLAME Randomized Phase III Trial by Kerkmeijer, Linda G W, Groen, Veerle H, Pos, Floris J, Haustermans, Karin, Monninkhof, Evelyn M, Smeenk, Robert Jan, Kunze-Busch, Martina, de Boer, Johannes C J, van der Voort van Zijp, Jochem, van Vulpen, Marco, Draulans, Cédric, van den Bergh, Laura, Isebaert, Sofie, van der Heide, Uulke A

“…This study investigates whether focal boosting of the macroscopic visible tumor with external beam radiotherapy increases biochemical disease-free survival…”
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Dose evaluation of fast synthetic-CT generation using a generative adversarial network for general pelvis MR-only radiotherapy by Maspero, Matteo, Savenije, Mark H F, Dinkla, Anna M, Seevinck, Peter R, Intven, Martijn P W, Jurgenliemk-Schulz, Ina M, Kerkmeijer, Linda G W, van den Berg, Cornelis A T

“…To enable magnetic resonance (MR)-only radiotherapy and facilitate modelling of radiation attenuation in humans, synthetic CT (sCT) images need to be…”
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Deep learning–based MR‐to‐CT synthesis: The influence of varying gradient echo–based MR images as input channels by Florkow, Mateusz C., Zijlstra, Frank, Willemsen, Koen, Maspero, Matteo, Berg, Cornelis A. T., Kerkmeijer, Linda G. W., Castelein, René M., Weinans, Harrie, Viergever, Max A., Stralen, Marijn, Seevinck, Peter R.

“…Purpose To study the influence of gradient echo–based contrasts as input channels to a 3D patch‐based neural network trained for synthetic CT (sCT) generation…”
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Primary endpoint analysis of the multicentre phase II hypo-FLAME trial for intermediate and high risk prostate cancer by Draulans, Cédric, van der Heide, Uulke A., Haustermans, Karin, Pos, Floris J., van der Voort van Zyp, Jochem, De Boer, Hans, Groen, Veerle H., Monninkhof, Evelyn M., Smeenk, Robert J., Kunze-Busch, Martina, De Roover, Robin, Depuydt, Tom, Isebaert, Sofie, Kerkmeijer, Linda G.W.

“…•Focal intraprostatic lesion SBRT boosting is associated with low acute toxicity.•No acute grade ≥3 toxicity was reported in the phase II hypo-FLAME…”
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Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy: A “Game Changer” for Prostate Treatment? by Pathmanathan, Angela U., van As, Nicholas J., Kerkmeijer, Linda G.W., Christodouleas, John, Lawton, Colleen A.F., Vesprini, Danny, van der Heide, Uulke A., Frank, Steven J., Nill, Simeon, Oelfke, Uwe, van Herk, Marcel, Li, X. Allen, Mittauer, Kathryn, Ritter, Mark, Choudhury, Ananya, Tree, Alison C.

“…Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated α/β ratio,…”
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Adaptive radiotherapy: The Elekta Unity MR-linac concept by Winkel, Dennis, Bol, Gijsbert H., Kroon, Petra S., van Asselen, Bram, Hackett, Sara S., Werensteijn-Honingh, Anita M., Intven, Martijn P.W., Eppinga, Wietse S.C., Tijssen, Rob H.N., Kerkmeijer, Linda G.W., de Boer, Hans C.J., Mook, Stella, Meijer, Gert J., Hes, Jochem, Willemsen-Bosman, Mirjam, de Groot-van Breugel, Eline N., Jürgenliemk-Schulz, Ina M., Raaymakers, Bas W.

“…•The Elekta Unity MR-linac adaptive radiotherapy concept is explained.•The adapt to shape and adapt to position workflows are compared.•Different methods for…”
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Patterns of Failure Following External Beam Radiotherapy With or Without an Additional Focal Boost in the Randomized Controlled FLAME Trial for Localized Prostate Cancer by Groen, Veerle H., Haustermans, Karin, Pos, Floris J., Draulans, Cédric, Isebaert, Sofie, Monninkhof, Evelyn M., Smeenk, Robert J., Kunze-Busch, Martina, de Boer, Johannes C.J., van der Voort van Zijp, Jochem, Kerkmeijer, Linda G.W., van der Heide, Uulke A.

“…Focal boosting up to 95 Gy in the FLAME trial improved rates of local failure and of regional + distant metastatic failure (rdMF) for patients with localized,…”
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MR-Guided Radiotherapy for Prostate Cancer by Tocco, Boris R, Kishan, Amar U, Ma, Ting Martin, Kerkmeijer, Linda G W, Tree, Alison C

“…External beam radiotherapy remains the primary treatment modality for localized prostate cancer. The radiobiology of prostate carcinoma lends itself to…”
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Magnetic Resonance Imaging–guided Adaptive Radiotherapy for Urological Cancers: What Urologists Should Know by Kerkmeijer, Linda G.W., Kishan, Amar U., Tree, Alison C.

“…Magnetic resonance imaging (MRI)-guided radiotherapy allows for online adaptation of the radiation plan on the basis of anatomical and functional changes…”
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Standard whole prostate gland radiotherapy with and without lesion boost in prostate cancer: Toxicity in the FLAME randomized controlled trial by Monninkhof, Evelyn M., van Loon, Juliette W.L., van Vulpen, Marco, Kerkmeijer, Linda G.W., Pos, Floris J., Haustermans, Karin, van den Bergh, Laura, Isebaert, Sofie, McColl, Gill M., Smeenk, Robert Jan, Noteboom, Juus, Walraven, Iris, Peeters, Petra H.M., van der Heide, Uulke A.

“…To compare toxicity rates in patients with localized prostate cancer treated with standard fractionated external beam radiotherapy (EBRT) with or without an…”
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Prostate tumor delineation using multiparametric magnetic resonance imaging: Inter-observer variability and pathology validation by Steenbergen, Peter, Haustermans, Karin, Lerut, Evelyne, Oyen, Raymond, De Wever, Liesbeth, Van den Bergh, Laura, Kerkmeijer, Linda G.W, Pameijer, Frank A, Veldhuis, Wouter B, van der Voort van Zyp, Jochem R.N, Pos, Floris J, Heijmink, Stijn W, Kalisvaart, Robin, Teertstra, Hendrik J, Dinh, Cuong V, Ghobadi, Ghazaleh, van der Heide, Uulke A

“…Abstract Background and purpose Boosting the dose to the largest (dominant) lesion in radiotherapy of prostate cancer may improve treatment outcome. The…”
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Advancing the treatment of localized prostate cancer with MR-guided radiotherapy by Reijnen, Casper, Brunenberg, Ellen J. L., Kerkmeijer, Linda G. W.

“…External beam radiotherapy (EBRT) is an important cornerstone in the treatment of localized prostate cancer. Current image-guided radiotherapy (IGRT)…”
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The MRI-Linear Accelerator Consortium: Evidence-Based Clinical Introduction of an Innovation in Radiation Oncology Connecting Researchers, Methodology, Data Collection, Quality Assurance, and Technical Development by Kerkmeijer, Linda G W, Fuller, Clifton D, Verkooijen, Helena M, Verheij, Marcel, Choudhury, Ananya, Harrington, Kevin J, Schultz, Chris, Sahgal, Arjun, Frank, Steven J, Goldwein, Joel, Brown, Kevin J, Minsky, Bruce D, van Vulpen, Marco

“…An international research consortium has been formed to facilitate evidence-based introduction of MR-guided radiotherapy (MR-linac) and to address how the…”
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Comparing adaptation strategies in MRI-guided online adaptive radiotherapy for prostate cancer: Implications for treatment margins by Dassen, Mathijs G., Janssen, Tomas, Kusters, Martijn, Pos, Floris, Kerkmeijer, Linda G.W., van der Heide, Uulke A., van der Bijl, Erik

“…•Daily re-delineation of the prostate does not reduce the required PTV margin.•Daily re-delineation of the seminal vesicles reduces the required PTV…”
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Lutetium-177-PSMA-617 in Low-Volume Hormone-Sensitive Metastatic Prostate Cancer: A Prospective Pilot Study by Privé, Bastiaan M, Peters, Steffie M B, Muselaers, Constantijn H J, van Oort, Inge M, Janssen, Marcel J R, Sedelaar, J P Michiel, Konijnenberg, Mark W, Zámecnik, Patrik, Uijen, Maike J M, Schilham, Melline G M, Eek, Annemarie, Scheenen, Tom W J, Verzijlbergen, J Fred, Gerritsen, Winald R, Mehra, Niven, Kerkmeijer, Linda G W, Smeenk, Robert J, Somford, Diederik M, van Basten, Jean-Paul A, Heskamp, Sandra, Barentsz, Jelle O, Gotthardt, Martin, Witjes, J Alfred, Nagarajah, James

“…[ Lu]Lu-PSMA-617 radioligand therapy ( Lu-PSMA) is a novel treatment for metastatic castration-resistant prostate cancer (mCRPC), which could also be applied…”
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From once-weekly to semi-weekly whole prostate gland stereotactic radiotherapy with focal boosting: Primary endpoint analysis of the multicenter phase II hypo-FLAME 2.0 trial by De Cock, Lisa, Draulans, Cédric, Pos, Floris J., Isebaert, Sofie, De Roover, Robin, van der Heide, Uulke A., Smeenk, Robert J., Kunze-Busch, Martina, van der Voort van Zyp, Jochem, de Boer, Hans, Kerkmeijer, Linda G.W., Haustermans, Karin

“…•The overall treatment time of focal boosted prostate SBRT can safely be reduced.•No acute grade ≥3 toxicity was reported for the semi-weekly (hypo-FLAME 2.0)…”
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R-IDEAL: A Framework for Systematic Clinical Evaluation of Technical Innovations in Radiation Oncology by Verkooijen, Helena M, Kerkmeijer, Linda G W, Fuller, Clifton D, Huddart, Robbert, Faivre-Finn, Corinne, Verheij, Marcel, Mook, Stella, Sahgal, Arjun, Hall, Emma, Schultz, Chris

“…The pace of innovation in radiation oncology is high and the window of opportunity for evaluation narrow. Financial incentives, industry pressure, and…”
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Editorial: Advances in radiotherapy for prostate cancer by Kamran, Sophia C, Kerkmeijer, Linda G W, Zamboglou, Constantinos

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Who needs a mean dose if you can FLAME? by Guricová, Karolína, van der Heide, Uulke A., Kerkmeijer, Linda G.W., Pos, Floris, Monninkhof, Evelyn, Haustermans, Karin

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An ESTRO-ACROP guideline on quality assurance and medical physics commissioning of online MRI guided radiotherapy systems based on a consensus expert opinion by Tanadini-Lang, Stephanie, Budgell, Geoff, Bohoudi, Omar, Corradini, Stefanie, Cusumano, Davide, Güngör, Görkem, Kerkmeijer, Linda G.W., Mahmood, Faisal, Nill, Simeon, Palacios, Miguel A., Reiner, Michael, Thorwarth, Daniela, Wilke, Lotte, Wolthaus, Jochem

“…•A consensus guideline on quality assurance and medical physics commissioning of online MRI guided radiotherapy systems applicable to all commercially…”
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