Search Results - "Kerkman, D J"

Multicenter assessment of CSF-phosphorylated tau for the prediction of conversion of MCI by EWERS, M, BUERGER, K, WALLIN, A, DEBERNARDIS, J. F, KERKMAN, D. J, HEINDL, B, BLENNOW, K, HAMPEL, H, TEIPEL, S. J, SCHELTENS, P, SCHRÖDER, J, ZINKOWSKI, R. P, BOUWMAN, F. H, SCHÖNKNECHT, P, SCHOONENBOOM, N. S. M, ANDREASEN, N

“…The measurement of hyperphosphorylated tau (p-tau) in CSF has been proposed as a biomarker candidate for the prediction of Alzheimer disease (AD) in patients…”
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Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment by de Leon, M.J., DeSanti, S., Zinkowski, R., Mehta, P.D., Pratico, D., Segal, S., Rusinek, H., Li, J., Tsui, W., Saint Louis, L.A., Clark, C.M., Tarshish, C., Li, Y., Lair, L., Javier, E., Rich, K., Lesbre, P., Mosconi, L., Reisberg, B., Sadowski, M., DeBernadis, J.F., Kerkman, D.J., Hampel, H., Wahlund, L.-O., Davies, P.

“…The diagnosis of Alzheimer's disease (AD) in patients with mild cognitive impairment (MCI) is limited because it is based on non-specific behavioral and…”
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Discovery of a novel class of orally active, non-peptide angiotensin II antagonists by De, B, Winn, M, Zydowsky, T. M, Kerkman, D. J, DeBernardis, J. F, Lee, J, Buckner, S, Warner, R, Brune, M

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Preclinical pharmacological actions of (+/-)-(1'R,3R)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine by Hancock, A A, Buckner, S A, Giardina, W J, Brune, M E, Lee, J Y, Morse, P A, Oheim, K W, Stanisic, D S, Warner, R B, Kerkman, D J

“…(+/-)-(1'R*,3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylene- dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) was evaluated in a…”
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Characterization of antihypertensive activity of ABBOTT-81988, a nonpeptide angiotensin II antagonist in the renal hypertensive rat by Lee, J Y, Buckner, S A, Brune, M E, Warner, R B, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, Debernardis, J F

“…2-(N-Propyl-N[(2'-[1H-tetrazol-5-yl]biphenyl-4yl)methyl]amin o) pyridine-3-carboxylic acid (ABBOTT-81988), a novel nonpeptide angiotensin II (AII) antagonist,…”
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Antihypertensive activity of ABBOTT-81282, a nonpeptide angiotensin II antagonist, in the renal hypertensive rat by Lee, J Y, Brune, M E, Warner, R B, Buckner, S B, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, DeBernardis, J F

“…ABBOTT-81282, 4-(N-butyl-N-[(2-'-[1H-tetrazol-5yl]biphenyl-4-yl)methyl]ami no) pyrimidine-5-carboxylic acid is a novel nonpeptide angiotensin II (AII)…”
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Cardiovascular effects of orally administered ABBOTT-81988, an angiotensin II antagonist, in conscious spontaneously hypertensive rats by Lee, J Y, Warner, R B, Brune, M E, Adler, A L, Winn, M, De, B, Zydowsky, T M, Opgenorth, T J, Kerkman, D J, DeBernardis, J F

“…ABBOTT-81988 (A-81988), 2-(N-propyl-N[(2'-[1H-tetrazol-5-yl]biphenyl- 4yl)methyl] amino) pyridine-3-carboxylic acid, a nonpeptide angiotensin II (AII)…”
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A-69024: a non-benzazepine antagonist with selectivity for the dopamine D-1 receptor by Kerkman, D J, Ackerman, M, Artman, L D, MacKenzie, R G, Johnson, M C, Bednarz, L, Montana, W, Asin, K E, Stampfli, H, Kebabian, J W

“…A-69024 HBr, 1-(2-bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2-methyl-1,2,3,4- tetrahydroisoquinoline hydrobromide, is a selective antagonist of the…”
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A new nasal decongestant, A-57219: a comparison with oxymetazoline by DeBernardis, J F, Winn, M, Kerkman, D J, Kyncl, J J, Buckner, S, Horrom, B

“…2-(4-Amino-3,5-dichlorobenzyl)imidazoline hydrochloride (A-57219), has alpha 1-agonist/alpha 2-antagonist activity and was more effective and long-acting than…”
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Adrenergic and dopaminergic properties of dopamine sulfoconjugates by Kyncl, J J, Buckner, S A, Brondyk, H, Kerkman, D J, DeBernardis, J F, Bush, E N, Kuchel, O

“…The 3- and 4-sulfate esters of dopamine (DA-3-SO4 and DA-4-SO4, respectively), the two main metabolites of DA, were evaluated for potential intrinsic or…”
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Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors by Hancock, A A, Buckner, S A, Lee, J Y, Brune, M, Morse, P A, Oheim, K, Warner, R B, Winn, M, Zydowsky, T M, De, B

“…Abbott-81282 (A-81282) has been identified among a series of related compounds as being a highly potent and selective antagonist of angiotensin receptors. At…”
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Effects of the putative antidepressant, ABT 200, on the clearance of exogenous norepinephrine in rat cerebellum by Cass, W A, Friedemann, M N, deBernardis, J F, Kerkman, D J, Gerhardt, G A

“…ABT 200 [(RR,SS)-3-phenyl-1-[1',2',3',4'-tetrahydro-5',6'-methylenedioxy- 1'-naphthalenyl-methyl]-pyrrolidine methanesulfonate] is a potent alpha…”
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Conformationally defined adrenergic agents. 4. 1-(Aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom by DeBernardis, John F, Arendsen, David L, Kyncl, John J, Kerkman, Daniel J

“…The synthesis of a series of 1-(aminomethyl)phthalans 1b is reported. The radioligand binding to alpha 1- and alpha 2-receptors and the in vitro pharmacology…”
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Conformationally defined adrenergic agents. 1. Design and synthesis of novel alpha 2 selective adrenergic agents: electrostatic repulsion based conformational prototypes by DeBernardis, J F, Kerkman, D J, Winn, M, Bush, E N, Arendsen, D L, McClellan, W J, Kyncl, J J, Basha, F Z

“…A previous report of the adrenergic selectivity of 2- and 6-fluoronorepinephrine prompted us to formulate a hypothesis that accounted for this selectivity on…”
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Conformationally defined adrenergic agents. 5. Resolution, absolute configuration, and pharmacological characterization of the enantiomers of 2-(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline: a potent agonist at .alpha.-adrenoceptors by DeBernardis, John F, Kerkman, Daniel J, Arendsen, David L, Buckner, Steve A, Kyncl, John J, Hancock, Arthur A

“…(+/-)-2-(5,6-Dimethoxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline has been resolved into its (+) and (-) enantiomers, and the absolute configuration was…”
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Conformationally defined adrenergic agents. 2. Catechol imidazoline derivatives: biological effects at alpha 1 and alpha 2 adrenergic receptors by DeBernardis, J F, Kyncl, J J, Basha, F Z, Arendsen, D L, Martin, Y C, Winn, M, Kerkman, D J

“…The synthesis and pharmacology of 2-(5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthyl)imidazoline (A-54741, 4), a very potent alpha-adrenergic agonist, are…”
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[3H]A-81988, a potent, selective, competitive antagonist radioligand for angiotensin AT1 receptors by Hancock, A A, Surber, B W, Rotert, G, Thomas, S, Tasker, A S, Sorensen, B K, Vodenlich, A D, Opgenorth, T J, Kerkman, D J, DeBernardis, J F

“…Abbott-81988 (A-81988), 2-(N-n-Propyl-N-[(2'-[1H-tetrazol-5-yl]biphenyl-4- yl)methyl]amino)pyridine-3-carboxylic acid is a potent, competitive, non-peptidic…”
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Discovery of a novel class of orally active, non-peptide angiotensin II antogonists by DE, B, WINN, M, OPGENORTH, T, MARSH, K, ZYDOWSKY, T. M, KERKMAN, D. J, DEBERNARDIS, J. F, LEE, L, BUCKNER, S, WARNER, R, BRUNE, M, HANCOCK, A

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Conformationally defined adrenergic agents. IV: 1-(Aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom by DEBERNARDIS, J. F, ARENDSEN, D. L, KYNCL, J. J, KERKMAN, D. J

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Conformationally defined adrenergic agents. 3. Modifications to the carbocyclic ring of 5,6-dihydroxy-1-(2-imidazolinyl)tetralin: improved separation of alpha 1 and alpha 2 adrenergic activities by DeBernardis, J F, Winn, M, Arendsen, D L, Kerkman, D J, Kyncl, J J

“…A series of modifications to positions 1, 2, and 4 of the tetralin ring of 5,6-dihydroxy-1-(2-imidazolinyl)tetralin (1, A-54741) succeeded in improving the…”
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