Search Results - "Kerkhoven, R"

Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma by Rozeman, E. A., Hoefsmit, E. P., Reijers, I. L. M., Saw, R. P. M., Versluis, J. M., Krijgsman, O., Dimitriadis, P., Sikorska, K., van de Wiel, B. A., Eriksson, H., Gonzalez, M., Torres Acosta, A., Grijpink-Ongering, L. G., Shannon, K., Haanen, J. B. A. G., Stretch, J., Ch’ng, S., Nieweg, O. E., Mallo, H. A., Adriaansz, S., Kerkhoven, R. M., Cornelissen, S., Broeks, A., Klop, W. M. C., Zuur, C. L., van Houdt, W. J., Peeper, D. S., Spillane, A. J., van Akkooi, A. C. J., Scolyer, R. A., Schumacher, T. N. M., Menzies, A. M., Long, G. V., Blank, C. U.

“…Neoadjuvant ipilimumab plus nivolumab showed high pathologic response rates (pRRs) in patients with macroscopic stage III melanoma in the phase 1b OpACIN (…”
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Tumor infiltrating lymphocytes predict benefit from TAC but not from ddAC in triple negative breast cancer in the randomized MATADOR trial (BOOG 2004-04) by van Rossum, A.G.J., Hoogstraat, M., Opdam, M., Horlings, H., Wessels, L., Kerkhoven, R.M., van Leeuwen - Stok, A.E., Oosterkamp, H.M., Kok, M., Linn, S.C.

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The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway by Nijman, Sebastian M.B., Huang, Tony T., Dirac, Annette M.G., Brummelkamp, Thijn R., Kerkhoven, Ron M., D'Andrea, Alan D., Bernards, René

“…Protein ubiquitination and deubiquitination are dynamic processes implicated in the regulation of numerous cellular pathways. Monoubiquitination of the Fanconi…”
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A large-scale RNAi screen in human cells identifies new components of the p53 pathway by Beijersbergen, Roderick L, Bernards, René, Berns, Katrien, Hijmans, E. Marielle, Mullenders, Jasper, Brummelkamp, Thijn R, Velds, Arno, Heimerikx, Mike, Kerkhoven, Ron M, Madiredjo, Mandy, Nijkamp, Wouter, Weigelt, Britta, Agami, Reuven, Ge, Wei, Cavet, Guy, Linsley, Peter S

“…RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic screens in lower organisms and can greatly facilitate the…”
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OC-0483: DNA repair defects in squamous cell carcinomas of the head and neck by Vens, C, Verhagen, C, Vossen, D, Hageman, F, Borgmann, K, Grenman, R, Kerkhoven, R, Verheij, M, Wessels, L, Van den Brekel, M.W.M

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Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins by Hateboer, G, Kerkhoven, R M, Shvarts, A, Bernards, R, Beijersbergen, R L

“…E2F transcription factors are key regulators of transcription during the cell cycle. E2F activity is regulated at the level of transcription and DNA binding…”
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Oncogenic pathways impinging on the G2-restriction point by Foijer, F, Simonis, M, van Vliet, M, Wessels, L, Kerkhoven, R, Sorger, P K, te Riele, H

“…In the absence of mitogenic stimuli, cells normally arrest in G 1/0 , because they fail to pass the G 1 -restriction point. However, abrogation of the G 1…”
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Platinum(II)-Based Coordination Compounds as Nucleic Acid Labeling Reagents: Synthesis, Reactivity, and Applications in Hybridization Assays by Heetebrij, R.J, Talman, E.G, Velzen, M.A. v, Gijlswijk, R.P.M. v, Snoeijers, S.S, Schalk, M, Wiegant, J, Rijke, F. v.d, Kerkhoven, R.M, Raap, A.K, Tanke, H.J, Reedijk, J, Houthoff, H.-J

“…The synthesis, characterization, and molecular interactions of platinum(II) coordination compounds, which contain a distal nonradioactive reporter molecule,…”
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Predicting cis-acting elements of Lactobacillus plantarum by comparative genomics with different taxonomic subgroups by Wels, Michiel, Francke, Christof, Kerkhoven, Robert, Kleerebezem, Michiel, Siezen, Roland J.

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E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo by Beijersbergen, R L, Kerkhoven, R M, Zhu, L, Carlée, L, Voorhoeve, P M, Bernards, R

“…The E2F family of transcription factors controls the expression of genes that are involved in cell cycle regulation. E2F DNA-binding activity is found in…”
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Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells by Brummelkamp, T R, Berns, K, Hijmans, E M, Mullenders, J, Fabius, A, Heimerikx, M, Velds, A, Kerkhoven, R M, Madiredjo, M, Bernards, R, Beijersbergen, R L

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The cost of home-based care for HIV/AIDS patients in Zimbabwe by HANSEN, K., WOELK, G., JACKSON, H., KERKHOVEN, R., MANJONJORI, N., MARAMBA, P., MUTAMBIRWA, J., NDIMANDE, E., VERA, E.

“…From a study on the cost and quality of community home-based care (CHBC) for HIV/AIDS patients in Zimbabwe, programme and household costs were estimated…”
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Developing AIDS Care in Zimbabwe: A case for residential community centres? by Jackson, H., Kerkhoven, R.

“…New support services are needed as the AIDS epidemic escalates. Home care has been the cornerstone of new developments in Zimbabwe and the southern Africa…”
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189PDTumor infiltrating lymphocytes predict benefit from TAC but not from ddAC in triple negative breast cancer in the randomized MATADOR trial (BOOG 2004-04) by van Rossum, A G J, Hoogstraat, M, Opdam, M, Horlings, H, Wessels, L, Kerkhoven, R M, van Leeuwen - Stok, A E, Oosterkamp, H M, Kok, M, Linn, S C

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LBA7518-months relapse-free survival (RFS) and biomarker analyses of OpACIN-neo: A study to identify the optimal dosing schedule of neoadjuvant (neoadj) ipilimumab (IPI) + nivolumab (NIVO) in stage III melanoma by Rozeman, E A, Menzies, A M, Krijgsman, O, Hoefsmit, E P, van de Wiel, B A, Sikorska, K, Van, T M, Eriksson, H, Bierman, C, Gonzalez, M, Shannon, K, Broeks, A, Kerkhoven, R, Spillane, A J, Saw, R P, van Akkooi, A C J, Scolyer, R A, Hansson, J, Long, G V, Blank, C U

“…Abstract Background Primary analysis of the OpACIN-neo study testing 3 dosing schedules of neoadj IPI+NIVO identified 2 cycles IPI 1 mg/kg + NIVO 3 mg/kg…”
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LBA75 - 18-months relapse-free survival (RFS) and biomarker analyses of OpACIN-neo: A study to identify the optimal dosing schedule of neoadjuvant (neoadj) ipilimumab (IPI) + nivolumab (NIVO) in stage III melanoma by Rozeman, E.A., Menzies, A.M., Krijgsman, O., Hoefsmit, E.P., van de Wiel, B.A., Sikorska, K., Van, T.M., Eriksson, H., Bierman, C., Gonzalez, M., Shannon, K., Broeks, A., Kerkhoven, R., Spillane, A.J., Saw, R.P., van Akkooi, A.C.J., Scolyer, R.A., Hansson, J., Long, G.V., Blank, C.U.

“…Primary analysis of the OpACIN-neo study testing 3 dosing schedules of neoadj IPI+NIVO identified 2 cycles IPI 1mg/kg + NIVO 3mg/kg (IPI1+NIVO3; arm B) as most…”
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18-months relapse-free survival (RFS) and biomarker analyses of OpACIN-neo: A study to identify the optimal dosing schedule of neoadjuvant (neoadj) ipilimumab (IPI) + nivolumab (NIVO) in stage III melanoma by Rozeman, E.A., Menzies, A.M., Krijgsman, O., Hoefsmit, E.P., van de Wiel, B.A., Sikorska, K., Van, T.M., Eriksson, H., Bierman, C., Gonzalez, M., Shannon, K., Broeks, A., Kerkhoven, R., Spillane, A.J., Saw, R.P., van Akkooi, A.C.J., Scolyer, R.A., Hansson, J., Long, G.V., Blank, C.U.

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Complete Genome Sequence of Lactobacillus plantarum WCFS1 by Kleerebezem, Michiel, Boekhorst, Jos, van Kranenburg, Richard, Molenaar, Douwe, Kuipers, Oscar P., Leer, Rob, Tarchini, Renato, Peters, Sander A., Sandbrink, Hans M., Mark W. E. J. Fiers, Stiekema, Willem, René M. Klein Lankhorst, Bron, Peter A., Hoffer, Sally M., Masja N. Nierop Groot, Kerkhoven, Robert, de Vries, Maaike, Ursing, Björn, de Vos, Willem M., Siezen, Roland J.

“…The 3,308,274-bp sequence of the chromosome of Lactobacillus plantarum strain WCFS1, a single colony isolate of strain NCIMB8826 that was originally isolated…”
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BS69, a novel adenovirus E1A‐associated protein that inhibits E1A transactivation by Hateboer, G., Gennissen, A., Ramos, Y.F., Kerkhoven, R.M., Sonntag‐Buck, V., Stunnenberg, H.G., Bernards, R.

“…The adenovirus E1A gene products are nuclear phosphoproteins that can transactivate the other adenovirus early genes as well as several cellular genes, and can…”
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Axonal mapping of the giant peptidergic neurons VD1 and RPD2 located in the CNS of the pond snail Lymnaea stagnalis, with particular reference to the innervation of the auricle of the heart by Kerkhoven, R M, Croll, R P, Van Minnen, J, Bogerd, J, Ramkema, M D, Lodder, H, Boer, H H

“…VD1 and RPD2 are two giant neuropeptidergic neurons located respectively in the visceral and right parietal ganglion of the central nervous system (CNS) of the…”
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