Search Results - "Kerkhof, Manon H."

Extracellular Matrix Stiffness and Composition Regulate the Myofibroblast Differentiation of Vaginal Fibroblasts by Ruiz-Zapata, Alejandra M, Heinz, Andrea, Kerkhof, Manon H, van de Westerlo-van Rijt, Cindy, Schmelzer, Christian E H, Stoop, Reinout, Kluivers, Kirsten B, Oosterwijk, Egbert

“…Fibroblast to myofibroblast differentiation is a key feature of wound-healing in soft tissues, including the vagina. Vaginal fibroblasts maintain the integrity…”
Get full text

Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology by Kluivers, Kirsten B, Lince, Sabrina L, Ruiz-Zapata, Alejandra M, Post, Wilke M, Cartwright, Rufus, Kerkhof, Manon H, Widomska, Joanna, De Witte, Ward, Pecanka, Jakub, Kiemeney, Lambertus A, Vermeulen, Sita H, Goeman, Jelle J, Allen-Brady, Kristina, Oosterwijk, Egbert, Poelmans, Geert

“…Pelvic organ prolapse (POP) represents a major health care burden in women, but its underlying pathophysiological mechanisms have not been elucidated. We first…”
Get full text

Changes in tissue composition of the vaginal wall of premenopausal women with prolapse by Kerkhof, Manon H., MD, Ruiz-Zapata, Alejandra M., MSc, Bril, Herman, MD, PhD, Bleeker, Maaike C.G., MD, PhD, Belien, Jeroen A.M., PhD, Stoop, Reinout, PhD, Helder, Marco N., PhD

“…Objective The objective of this study was to compare histological and biochemical features of the (normal) precervical anterior vaginal wall and the prolapsed…”
Get full text

The Efficacy of Botulinum Toxin A Injection in Pelvic Floor Muscles in Chronic Pelvic Pain Patients: A Double‐Blinded Randomised Controlled Trial by Spruijt, Melle A., Klerkx, Wenche M., Notten, Kim, van Eijndhoven, Hugo, Speksnijder, Leonie, Kerkhof, Manon H., Kuivers, Kirsten B.

“…ABSTRACT Objective To evaluate and compare the efficacy and safety of Botulinum Toxin A (BTA) injections versus placebo injections, combined with pelvic floor…”
Get full text

Regenerative medicine as a therapeutic option for fecal incontinence: a systematic review of preclinical and clinical studies by De Ligny, Wiep R., Kerkhof, Manon H., Ruiz-Zapata, Alejandra M.

“…Fecal incontinence is the uncontrollable loss of stool and has a prevalence of around 7-15%. This condition has serious implications for patients’ quality of…”
Get full text

Management of post-midurethral sling voiding dysfunction. International Urogynecological Association research and development committee opinion by Bazi, Tony, Kerkhof, Manon H., Takahashi, Satoru I., Abdel-Fattah, Mohamed

“…Voiding dysfunction following midurethral sling procedures is not a rare event. There is no current consensus regarding management of this complication…”
Get full text

Obesity and pelvic organ prolapse by Lee, Una J, Kerkhof, Manon H, van Leijsen, Sanne A, Heesakkers, John P

“…PURPOSE OF REVIEWThe purpose of this review is to review the data on the relationship of obesity and pelvic organ prolapse (POP). This review is timely and…”
Get full text

The efficacy of botulinum toxin a injections in pelvic floor muscles in chronic pelvic pain patients: a systematic review and meta-analysis by Spruijt, Melle A., Klerkx, Wenche M., Kelder, Johannes C., Kluivers, Kirsten B., Kerkhof, Manon H.

“…Introduction and hypothesis Chronic pelvic pain (CPP) is a common multifactorial condition affecting 6 to 27% of women aged 18–50 years worldwide. This study…”
Get full text

Toward a new generation of pelvic floor implants with electrospun nanofibrous matrices: A feasibility study by Vashaghian, Mahshid, Ruiz‐Zapata, Alejandra M., Kerkhof, Manon H., Zandieh‐Doulabi, Behrouz, Werner, Arie, Roovers, Jan Paul, Smit, Theo H.

“…Objective The use of knitted, polypropylene meshes for the surgical treatment of pelvic organ prolapse (POP) is frequently accompanied by severe complications…”
Get full text

Vaginal Fibroblastic Cells from Women with Pelvic Organ Prolapse Produce Matrices with Increased Stiffness and Collagen Content by Ruiz-Zapata, Alejandra M., Kerkhof, Manon H., Ghazanfari, Samaneh, Zandieh-Doulabi, Behrouz, Stoop, Reinout, Smit, Theo H., Helder, Marco N.

“…Pelvic organ prolapse (POP) is characterised by the weakening of the pelvic floor support tissues, and often by subsequent prolapse of the bladder outside the…”
Get full text

Functional characteristics of vaginal fibroblastic cells from premenopausal women with pelvic organ prolapse by Ruiz-Zapata, Alejandra M, Kerkhof, Manon H, Zandieh-Doulabi, Behrouz, Brölmann, Hans A M, Smit, Theo H, Helder, Marco N

“…Pelvic organ prolapse (POP) remains a great therapeutic challenge with no optimal treatment available. Tissue maintenance and remodelling are performed by…”
Get full text

Fibroblasts from women with pelvic organ prolapse show differential mechanoresponses depending on surface substrates by Ruiz-Zapata, Alejandra M., Kerkhof, Manon H., Zandieh-Doulabi, Behrouz, Brölmann, Hans A. M., Smit, Theo H., Helder, Marco N.

“…Introduction and hypothesis Little is known about dynamic cell-matrix interactions in the context of pathophysiology and treatments for pelvic organ prolapse…”
Get full text

Exome chip study provides novel insights into the genetics of pelvic organ prolapse by Lince, Sabrina L, Kluivers, Kirsten B, Cartwright, Rufus, Ruiz-Zapata, Alejandra M, Kerkhof, Manon H, Pecanka, Jakub, Kiemeney, Lambertus A, Vermeulen, Sita H, Goeman, Jelle J, Allen-Brady, Kristina, Norton, Peggy A, Oosterwijk, Egbert, Poelmans, Geert

Get full text

Variation in the practice of laparoscopic sacrohysteropexy and laparoscopic sacrocolpopexy for the treatment of pelvic organ prolapse: a Dutch survey by van IJsselmuiden, Mèlanie N., Kerkhof, Manon H., Schellart, René P., Bongers, Marlies Y., Spaans, Wilbert A., van Eijndhoven, Hugo W. F.

“…Introduction and hypothesis Laparoscopic techniques for pelvic organ prolapse surgery using mesh are gaining interest. A standard approach or published…”
Get full text

Case report by Kerkhof, Manon H, Scholten, Irma

Get full text

Reply by De Ligny, Wiep R., Kerkhof, Manon H., Ruiz-Zapata, Alejandra M.

Get full text

Nausea, vomiting, malaise, frequent urination--Dx? by Kerkhof, Manon H, Scholten, Irma

Get full text

Wound healing of the pelvic floor concerning pelvic organ prolapse --What do we know?/Cicatrizacao do assoalho pelvico e relacao com prolapso de orgao pelvico --O que sabemos? by Furtado Fernandes Terra, Maria Eduarda, Ruiz-Zapata, Alejandra Maria, Kluivers, Kirsten B, Helder, Marco N, Kerkhof, Manon H

“…Pelvic organ prolapse (POP) is a result of the pelvic's floor supportive tissues weakening, including levator ani muscles, endopelvic fascia, ligaments, and…”
Get full text

Reply by De Ligny, Wiep R, Kerkhof, Manon H, Ruiz-Zapata, Alejandra M

Get full text

Reply by De Ligny, Wiep R, Kerkhof, Manon H, Ruiz-Zapata, Alejandra M

Get full text