Search Results - "Keren, Zohar"

Knockdown of DJ-1 Resulted in a Coordinated Activation of the Innate Immune Antiviral Response in HEK293 Cell Line by Zohar, Keren, Linial, Michal

“…PARK7, also known as DJ-1, plays a critical role in protecting cells by functioning as a sensitive oxidation sensor and modulator of antioxidants. DJ-1 acts to…”
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Challenging Cellular Homeostasis: Spatial and Temporal Regulation of miRNAs by van Wijk, Naomi, Zohar, Keren, Linial, Michal

“…Mature microRNAs (miRNAs) are single-stranded non-coding RNA (ncRNA) molecules that act in post-transcriptional regulation in animals and plants. A mature…”
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Targeted in situ cross-linking mass spectrometry and integrative modeling reveal the architectures of three proteins from SARS-CoV-2 by Slavin, Moriya, Zamel, Joanna, Zohar, Keren, Eliyahu, Tsiona, Braitbard, Merav, Brielle, Esther, Baraz, Leah, Stolovich-Rain, Miri, Friedman, Ahuva, Wolf, Dana G., Rouvinski, Alexander, Linial, Michal, Schneidman-Duhovny, Dina, Kalisman, Nir

“…Atomic structures of several proteins from the coronavirus family are still partial or unavailable. A possible reason for this gap is the instability of these…”
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Coordinated Transcriptional Waves Define the Inflammatory Response of Primary Microglial Culture by Zohar, Keren, Lezmi, Elyad, Reichert, Fanny, Eliyahu, Tsiona, Rotshenker, Shlomo, Weinstock, Marta, Linial, Michal

“…The primary role of microglia is to maintain homeostasis by effectively responding to various disturbances. Activation of transcriptional programs determines…”
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Spliceosome-Associated microRNAs Signify Breast Cancer Cells and Portray Potential Novel Nuclear Targets by Mahlab-Aviv, Shelly, Zohar, Keren, Cohen, Yael, Peretz, Ayelet R, Eliyahu, Tsiona, Linial, Michal, Sperling, Ruth

“…MicroRNAs (miRNAs) act as negative regulators of gene expression in the cytoplasm. Previous studies have identified the presence of miRNAs in the nucleus. Here…”
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Oxidative Stress and Its Modulation by Ladostigil Alter the Expression of Abundant Long Non-Coding RNAs in SH-SY5Y Cells by Zohar, Keren, Giladi, Eliran, Eliyahu, Tsiona, Linial, Michal

“…Neurodegenerative disorders, brain injury, and the decline in cognitive function with aging are accompanied by a reduced capacity of cells in the brain to cope…”
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Ladostigil Attenuates Induced Oxidative Stress in Human Neuroblast-like SH-SY5Y Cells by Zohar, Keren, Lezmi, Elyad, Eliyahu, Tsiona, Linial, Michal

“…A hallmark of the aging brain is the robust inflammation mediated by microglial activation. Pathophysiology of common neurodegenerative diseases involves…”
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Ladostigil Reduces the Adenoside Triphosphate/Lipopolysaccharide-Induced Secretion of Pro-Inflammatory Cytokines from Microglia and Modulate-Immune Regulators, TNFAIP3, and EGR1 by Reichert, Fanny, Zohar, Keren, Lezmi, Elyad, Eliyahu, Tsiona, Rotshenker, Shlomo, Linial, Michal, Weinstock, Marta

“…Treatment of aging rats for 6 months with ladostigil (1 mg/kg/day) prevented a decline in recognition and spatial memory and suppressed the overexpression of…”
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B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging by Keren, Zohar, Naor, Shulamit, Nussbaum, Shahar, Golan, Karin, Itkin, Tomer, Sasaki, Yoshiteru, Schmidt-Supprian, Marc, Lapidot, Tsvee, Melamed, Doron

“…Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the…”
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Building Orientation and Post Processing of Ti6Al4V Produced by Laser Powder Bed Fusion Process by Rovetta, Rosaria, Ginestra, Paola, Ferraro, Rosalba Monica, Zohar-Hauber, Keren, Giliani, Silvia, Ceretti, Elisabetta

“…Laser powder bed fusion, particularly the selective laser melting (SLM), is an additive manufacturing (AM) technology used to produce near-net-shaped…”
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Depletion of B lymphocytes in rheumatoid arthritis patients modifies IL-8-anti-IL-8 autoantibody network by Keren, Zohar, Braun-Moscovici, Yolanda, Markovits, Doron, Rozin, Alexander, Nahir, Menahem, Balbir-Gurman, Alexandra, Melamed, Doron

“…Abstract Cytokines and chemokines are key regulatory molecules involved in rheumatoid arthritis (RA). B-cell depletion therapy improves RA clinically but its…”
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Modification of Ligand-independent B Cell Receptor Tonic Signals Activates Receptor Editing in Immature B Lymphocytes by Keren, Zohar, Diamant, Eran, Ostrovsky, Olga, Bengal, Eyal, Melamed, Doron

“…Maturation of B lymphocytes strictly depends on the signaling competence of the B cell antigen receptor (BCR). Autoreactive receptors undergo negative…”
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Facilitating In Situ Cross-Linking and Mass Spectrometry by Antibody-Based Protein Enrichment by Zamel, Joanna, Cohen, Shon, Zohar, Keren, Kalisman, Nir

“…Cross-linking of living cells followed by mass spectrometry identification of cross-linked peptides (in situ CLMS) is an emerging technology to study protein…”
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Synthesis of stabilized nanoparticles of zinc peroxide by Rosenthal-Toib, Liora, Zohar, Keren, Alagem, Meital, Tsur, Yoed

“…Stabilized nanoparticles of zinc peroxide were formed by a novel and simple technique. The technique is based on oxidation–hydrolysis–precipitation procedure,…”
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Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy by Falik Zaccai, Tzipora C, Savitzki, David, Zivony-Elboum, Yifat, Vilboux, Thierry, Fitts, Eric C, Shoval, Yishay, Kalfon, Limor, Samra, Nadra, Keren, Zohar, Gross, Bella, Chasnyk, Natalia, Straussberg, Rachel, Mullikin, James C, Teer, Jamie K, Geiger, Dan, Kornitzer, Daniel, Bitterman-Deutsch, Ora, Samson, Abraham O, Wakamiya, Maki, Peterson, Johnny W, Kirtley, Michelle L, Pinchuk, Iryna V, Baze, Wallace B, Gahl, William A, Kleta, Robert, Anikster, Yair, Chopra, Ashok K

“…Leukoencephalopathies are a group of white matter disorders related to abnormal formation, maintenance, and turnover of myelin in the central nervous system…”
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Development of ALS-like disease in SOD-1 mice deficient of B lymphocytes by Naor, Shulamit, Keren, Zohar, Bronshtein, Tomer, Goren, Efrat, Machluf, Marcelle, Melamed, Doron

“…Several recent studies proposed a role for innate immunity and inflammation in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, possible…”
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Chronic B cell deficiency from birth prevents age-related alterations in the B lineage by Keren, Zohar, Averbuch, Dana, Shahaf, Gitit, Zisman-Rozen, Simona, Golan, Karin, Itkin, Tomer, Lapidot, Tsvee, Mehr, Ramit, Melamed, Doron

“…Aging is accompanied by a decline in B lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. The mechanisms underlying…”
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Phospholipase A 2 -activating protein is associated with a novel form of leukoencephalopathy by Falik Zaccai, Tzipora C., Savitzki, David, Zivony-Elboum, Yifat, Vilboux, Thierry, Fitts, Eric C., Shoval, Yishay, Kalfon, Limor, Samra, Nadra, Keren, Zohar, Gross, Bella, Chasnyk, Natalia, Straussberg, Rachel, Mullikin, James C., Teer, Jamie K., Geiger, Dan, Kornitzer, Daniel, Bitterman-Deutsch, Ora, Samson, Abraham O., Wakamiya, Maki, Peterson, Johnny W., Kirtley, Michelle L., Pinchuk, Iryna V., Baze, Wallace B., Gahl, William A., Kleta, Robert, Anikster, Yair, Chopra, Ashok K.

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Selective Laser Melting and Electron Beam Melting of Ti6Al4V for Orthopedic Applications: A Comparative Study on the Applied Building Direction by Ginestra, Paola, Ferraro, Rosalba Monica, Zohar-Hauber, Keren, Abeni, Andrea, Giliani, Silvia, Ceretti, Elisabetta

“…The 3D printing process offers several advantages to the medical industry by producing complex and bespoke devices that accurately reproduce customized patient…”
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CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing by Diamant, Eran, Keren, Zohar, Melamed, Doron

“…Ligand-independent signals that are produced by the B-cell antigen receptor (BCR) confer an important positive selection checkpoint for immature B cells…”
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