LEVELS OF KEY CYTOKINES, MACROGLOBULINS AND THEIR SPECIFIC IMMUNE COMPLEXES IN BLOOD SERA OF WOMEN TAKING COMBINED ORAL CONTRACEPTIVES
We investigated effects of combined oral contraceptives (COC) containing low- and microdoses of estrogenic components upon serum levels of macroglobulin family proteins (alpha-2-macroglobulin, α2-MG, and pregnancy-associated alpha-2-glycoprotein, α2-PAG), their immune complexes with IgG, as well as...
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| Published in: | Medit͡s︡inskai͡a︡ immunologii͡a Vol. 13; no. 6; pp. 635 - 638 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
23-07-2014
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | We investigated effects of combined oral contraceptives (COC) containing low- and microdoses of estrogenic components upon serum levels of macroglobulin family proteins (alpha-2-macroglobulin, α2-MG, and pregnancy-associated alpha-2-glycoprotein, α2-PAG), their immune complexes with IgG, as well as concentrations of some cytokines (IL-1β, IL-6, TNFα, IFNγ). It was shown that cytokine levels did not differ with control, whereas α2-MG concentrations showed a time-dependent decrease in a group of women taking COC with microdoses of estrogens, and α2-PAG levels increased tenfold, independent on dosage and time of COC application. Meanwhile, contents of PAG-IgG complexes exhibits a gradual decrease, along with increase in MG-IgG. Considering PAG as a marker of normal and malignant proliferation, we suggest, that the levels of α2-PAG may be useful in monitoring of women taking COC, in order to predict high risk of pathological proliferation by evaluation of individuals with elevated α2-PAG levels. (Med. Immunol., 2011, vol. 13, N 6, pp 635-638) |
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| ISSN: | 1563-0625 2313-741X |
| DOI: | 10.15789/1563-0625-2011-6-635-638 |