Search Results - "Keränen, Mikko A. I."

Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia by Lundgren, Sofie, Keränen, Mikko A. I., Kankainen, Matti, Huuhtanen, Jani, Walldin, Gunilla, Kerr, Cassandra M., Clemente, Michael, Ebeling, Freja, Rajala, Hanna, Brück, Oscar, Lähdesmäki, Harri, Hannula, Sari, Hannunen, Tiina, Ellonen, Pekka, Young, Neal S., Ogawa, Seishi, Maciejewski, Jaroslaw P., Hellström-Lindberg, Eva, Mustjoki, Satu

“…The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common. In…”
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Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia by Douglas, Suvi P. M., Lahtinen, Atte K., Koski, Jessica R., Leimi, Lilli, Keränen, Mikko A. I., Koskenvuo, Minna, Heckman, Caroline A., Jahnukainen, Kirsi, Pitkänen, Esa, Wartiovaara-Kautto, Ulla, Kilpivaara, Outi

“…Despite recent progress in acute lymphoblastic leukemia (ALL) therapies, a significant subset of adult and pediatric ALL patients has a dismal prognosis…”
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Gemtuzumab-Ozogamicin-Related Impaired Hemoglobin-Haptoglobin Scavenging as On-Target/Off-Tumor Toxicity of Anti-CD33 AML Therapy: A Report of Two Cases by Rajala, Hanna L. M., Anttila, Veli-Jukka, Haapio, Mikko, Keränen, Mikko A. I., Wartiovaara-Kautto, Ulla, Räty, Riikka

“…Gemtuzumab-ozogamicin (GO) is a humanized anti-CD33 antibody, which is conjugated to a cytotoxic calicheamicin. It is used to treat acute myeloid leukemia…”
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Clonal hematopoiesis in patients with rheumatoid arthritis by Savola, Paula, Lundgren, Sofie, Keränen, Mikko A. I., Almusa, Henrikki, Ellonen, Pekka, Leirisalo-Repo, Marjatta, Kelkka, Tiina, Mustjoki, Satu

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Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants by Raissadati, Alireza, Jokinen, Janne J, Syrjälä, Simo O, Keränen, Mikko A I, Krebs, Rainer, Tuuminen, Raimo, Arnaudova, Ralica, Rouvinen, Eeva, Anisimov, Andrey, Soronen, Jarkko, Pajusola, Katri, Alitalo, Kari, Nykänen, Antti I, Lemström, Karl

“…Heart transplant gene therapy requires vectors with long-lasting gene expression, high cardiotropism, and minimal pathological effects. Here, we examined…”
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Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease by Kim, Daehong, Park, Giljun, Huuhtanen, Jani, Lundgren, Sofie, Khajuria, Rajiv K., Hurtado, Ana M., Muñoz-Calleja, Cecilia, Cardeñoso, Laura, Gómez-García de Soria, Valle, Chen-Liang, Tzu Hua, Eldfors, Samuli, Ellonen, Pekka, Hannula, Sari, Kankainen, Matti, Bruck, Oscar, Kreutzman, Anna, Salmenniemi, Urpu, Lönnberg, Tapio, Jerez, Andrés, Itälä-Remes, Maija, Myllymäki, Mikko, Keränen, Mikko A. I., Mustjoki, Satu

“…Graft versus host disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). Here we report studies of a patient…”
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Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts by NYKÄNEN, Antti I, SANDELIN, Henrik, ALITALO, Kari, LEMSTRÖM, Karl B, KREBS, Rainer, KERÄNEN, Mikko A. I, TUUMINEN, Raimo, KÄRPÄNEN, Terhi, YAN WU, PYTOWSKI, Bronislaw, KOSKINEN, Petri K, YLÄ-HERTTUALA, Seppo

“…Lymphatic network and chemokine-mediated signals are essential for leukocyte traffic during the proximal steps of alloimmune response. We aimed to determine…”
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Donor Simvastatin Treatment Abolishes Rat Cardiac Allograft Ischemia/Reperfusion Injury and Chronic Rejection Through Microvascular Protection by TUUMINEN, Raimo, SYRJALA, Simo, KREBS, Rainer, KERÄNEN, Mikko A. I, KOLI, Katri, ABO-RAMADAN, Usama, NEUVONEN, Pertti J, TIKKANEN, Jussi M, NYKANEN, Antti I, LEMSTRÖM, Karl B

“…Ischemia/reperfusion injury may have deleterious short- and long-term consequences for cardiac allografts. The underlying mechanisms involve microvascular…”
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Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury by Tuuminen, Raimo, Dashkevich, Alexey, Keränen, Mikko A I, Raissadati, Alireza, Krebs, Rainer, Jokinen, Janne J, Arnaudova, Ralica, Rouvinen, Eeva, Ylä-Herttuala, Seppo, Nykänen, Antti I, Lemström, Karl B

“…BACKGROUNDMicrovascular dysfunction and cardiomyocyte injury are hallmarks of ischemia-reperfusion injury (IRI) after heart transplantation. Platelet-derived…”
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Author Correction: Clonal hematopoiesis in patients with rheumatoid arthritis by Savola, Paula, Lundgren, Sofie, Keränen, Mikko A. I., Almusa, Henrikki, Ellonen, Pekka, Leirisalo-Repo, Marjatta, Kelkka, Tiina, Mustjoki, Satu

“…A Correction to this paper has been published: https://doi.org/10.1038/s41408-021-00427-1…”
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Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity by Dufva, Olli, Koski, Jan, Maliniemi, Pilvi, Ianevski, Aleksandr, Klievink, Jay, Leitner, Judith, Pölönen, Petri, Hohtari, Helena, Saeed, Khalid, Hannunen, Tiina, Ellonen, Pekka, Steinberger, Peter, Kankainen, Matti, Aittokallio, Tero, Keränen, Mikko A.I., Korhonen, Matti, Mustjoki, Satu

“…Chimeric antigen receptor (CAR) T-cell therapy has proven effective in relapsed and refractory B-cell malignancies, but resistance and relapses still occur…”
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Angiogenic growth factors in cardiac allograft rejection by NYKÄNEN, Antti I, TIKKANEN, Jussi M, KREBS, Rainer, KERÄNEN, Mikko A. I, SIHVOLA, Roope K, SANDELIN, Henrik, TUUMINEN, Raimo, RAISKY, Olivier, KOSKINEN, Petri K, LEMSTRÖM, Karl B

“…Normal adult vasculature is in a quiescent state. In transplanted hearts, peri- and postoperative ischemic and alloimmune stimuli may be interpreted as…”
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Immunogenomic Landscape of Hematological Malignancies by Dufva, Olli, Pölönen, Petri, Brück, Oscar, Keränen, Mikko A.I., Klievink, Jay, Mehtonen, Juha, Huuhtanen, Jani, Kumar, Ashwini, Malani, Disha, Siitonen, Sanna, Kankainen, Matti, Ghimire, Bishwa, Lahtela, Jenni, Mattila, Pirkko, Vähä-Koskela, Markus, Wennerberg, Krister, Granberg, Kirsi, Leivonen, Suvi-Katri, Meriranta, Leo, Heckman, Caroline, Leppä, Sirpa, Nykter, Matti, Lohi, Olli, Heinäniemi, Merja, Mustjoki, Satu

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Somatic mutations and T-cell clonality in patients with immunodeficiency by Savola, Paula, Martelius, Timi, Kankainen, Matti, Huuhtanen, Jani, Lundgren, Sofie, Koski, Yrjö, Eldfors, Samuli, Kelkka, Tiina, Keränen, Mikko A I, Ellonen, Pekka, Kovanen, Panu E, Kytölä, Soili, Saarela, Janna, Lähdesmäki, Harri, Seppänen, Mikko R J, Mustjoki, Satu

“…Common variable immunodeficiency and other late-onset immunodeficiencies often co-manifest with autoimmunity and lymphoproliferation. The pathogenesis of most…”
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Common Protective and Diverse Smooth Muscle Cell Effects of AAV-Mediated Angiopoietin-1 and -2 Expression in Rat Cardiac Allograft Vasculopathy by Nykänen, Antti I, Pajusola, Katri, Krebs, Rainer, Keränen, Mikko A.I, Raisky, Olivier, Koskinen, Petri K, Alitalo, Kari, Lemström, Karl B

“…Angiopoietin-1 (Ang1) and Ang2 regulate the maintenance of normal vasculature by direct endothelial and indirect smooth muscle cell (SMC) effects. Dysfunction…”
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VEGFR-1 and -2 Regulate Inflammation, Myocardial Angiogenesis, and Arteriosclerosis in Chronically Rejecting Cardiac Allografts by Raisky, Olivier, Nykänen, Antti I, Krebs, Rainer, Hollmén, Maria, Keränen, Mikko A.I, Tikkanen, Jussi M, Sihvola, Roope, Alhonen, Leena, Salven, Petri, Wu, Yan, Hicklin, Daniel J, Alitalo, Kari, Koskinen, Petri K, Lemström, Karl B

“…OBJECTIVE—Interplay between inflammation and angiogenesis is important in pathological reparative processes such as arteriosclerosis. We investigated how the…”
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Somatic mutations associate with clonal expansion of CD8 + T cells by Lundgren, Sofie, Myllymäki, Mikko, Järvinen, Timo, Keränen, Mikko A I, Theodoropoulos, Jason, Smolander, Johannes, Kim, Daehong, Salmenniemi, Urpu, Walldin, Gunilla, Savola, Paula, Kelkka, Tiina, Rajala, Hanna, Hellström-Lindberg, Eva, Itälä-Remes, Maija, Kankainen, Matti, Mustjoki, Satu

“…Somatic mutations in T cells can cause cancer but also have implications for immunological diseases and cell therapies. The mutation spectrum in nonmalignant T…”
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PDGF-A, -C, and -D but not PDGF-B Increase TGF-β1 and Chronic Rejection in Rat Cardiac Allografts by TUUMINEN, Raimo, NYKÄNEN, Antti I, KREBS, Rainer, SORONEN, Jarkko, PAJUSOLA, Katri, KERÄNEN, Mikko A. I, KOSKINEN, Petri K, ALITALO, Kari, LEMSTRÖM, Karl B

“…Objective— Chronic rejection is the main reason for the poor long-term survival of heart transplant recipients and is characterized by cardiac allograft…”
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Increased Th17 rather than Th1 alloimmune response is associated with cardiac allograft vasculopathy after hypothermic preservation in the rat by Syrjälä, Simo O., MD, Keränen, Mikko A.I., MD, Tuuminen, Raimo, MD, Nykänen, Antti I., MD, Tammi, Markku, MD, PhD, Krebs, Rainer, MS, Lemström, Karl B., MD, PhD

“…Background Preservation injury decreases patient survival and promotes the development of cardiac allograft vasculopathy. We investigated the sequential…”
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Immunogenomic Landscape of Hematological Malignancies by Dufva, Olli, Pölönen, Petri, Brück, Oscar, Keränen, Mikko A.I., Klievink, Jay, Mehtonen, Juha, Huuhtanen, Jani, Kumar, Ashwini, Malani, Disha, Siitonen, Sanna, Kankainen, Matti, Ghimire, Bishwa, Lahtela, Jenni, Mattila, Pirkko, Vähä-Koskela, Markus, Wennerberg, Krister, Granberg, Kirsi, Leivonen, Suvi-Katri, Meriranta, Leo, Heckman, Caroline, Leppä, Sirpa, Nykter, Matti, Lohi, Olli, Heinäniemi, Merja, Mustjoki, Satu

“…Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000…”
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