Search Results - "Keränen, I."

Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia by Lundgren, Sofie, Keränen, Mikko A. I., Kankainen, Matti, Huuhtanen, Jani, Walldin, Gunilla, Kerr, Cassandra M., Clemente, Michael, Ebeling, Freja, Rajala, Hanna, Brück, Oscar, Lähdesmäki, Harri, Hannula, Sari, Hannunen, Tiina, Ellonen, Pekka, Young, Neal S., Ogawa, Seishi, Maciejewski, Jaroslaw P., Hellström-Lindberg, Eva, Mustjoki, Satu

“…The prevalence and functional impact of somatic mutations in nonleukemic T cells is not well characterized, although clonal T-cell expansions are common. In…”
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Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia by Douglas, Suvi P. M., Lahtinen, Atte K., Koski, Jessica R., Leimi, Lilli, Keränen, Mikko A. I., Koskenvuo, Minna, Heckman, Caroline A., Jahnukainen, Kirsi, Pitkänen, Esa, Wartiovaara-Kautto, Ulla, Kilpivaara, Outi

“…Despite recent progress in acute lymphoblastic leukemia (ALL) therapies, a significant subset of adult and pediatric ALL patients has a dismal prognosis…”
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Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease by Kim, Daehong, Park, Giljun, Huuhtanen, Jani, Lundgren, Sofie, Khajuria, Rajiv K., Hurtado, Ana M., Muñoz-Calleja, Cecilia, Cardeñoso, Laura, Gómez-García de Soria, Valle, Chen-Liang, Tzu Hua, Eldfors, Samuli, Ellonen, Pekka, Hannula, Sari, Kankainen, Matti, Bruck, Oscar, Kreutzman, Anna, Salmenniemi, Urpu, Lönnberg, Tapio, Jerez, Andrés, Itälä-Remes, Maija, Myllymäki, Mikko, Keränen, Mikko A. I., Mustjoki, Satu

“…Graft versus host disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). Here we report studies of a patient…”
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Ischemia–Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts by Dashkevich, A., Raissadati, A., Syrjälä, S. O., Zarkada, G., Keränen, M. A. I., Tuuminen, R., Krebs, R., Anisimov, A., Jeltsch, M., Leppänen, V.‐M., Alitalo, K., Nykänen, A. I., Lemström, K. B.

“…Organ damage and innate immunity during heart transplantation may evoke adaptive immunity with serious consequences. Because lymphatic vessels bridge innate…”
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Angiopoietin‐2 Inhibition Prevents Transplant Ischemia‐Reperfusion Injury and Chronic Rejection in Rat Cardiac Allografts by Syrjälä, S. O., Tuuminen, R., Nykänen, A. I., Raissadati, A., Dashkevich, A., Keränen, M. A. I., Arnaudova, R., Krebs, R., Leow, C. C., Saharinen, P., Alitalo, K., Lemström, K. B.

“…Transplant ischemia‐reperfusion injury (Tx‐IRI) and allograft dysfunction remain as two of the major clinical challenges after heart transplantation. We…”
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Gemtuzumab-Ozogamicin-Related Impaired Hemoglobin-Haptoglobin Scavenging as On-Target/Off-Tumor Toxicity of Anti-CD33 AML Therapy: A Report of Two Cases by Rajala, Hanna L. M., Anttila, Veli-Jukka, Haapio, Mikko, Keränen, Mikko A. I., Wartiovaara-Kautto, Ulla, Räty, Riikka

“…Gemtuzumab-ozogamicin (GO) is a humanized anti-CD33 antibody, which is conjugated to a cytotoxic calicheamicin. It is used to treat acute myeloid leukemia…”
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Donor Simvastatin Treatment Prevents Ischemia‐Reperfusion and Acute Kidney Injury by Preserving Microvascular Barrier Function by Tuuminen, R., Nykänen, A. I., Saharinen, P., Gautam, P., Keränen, M. A. I., Arnaudova, R., Rouvinen, E., Helin, H., Tammi, R., Rilla, K., Krebs, R., Lemström, K. B.

“…Ischemia‐reperfusion injury (IRI) after kidney transplantation may result in delayed graft function. We used rat renal artery clamping and transplantation…”
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Donor Heart Treatment With COMP‐Ang1 Limits Ischemia‐Reperfusion Injury and Rejection of Cardiac Allografts by Syrjälä, S. O., Nykänen, A. I., Tuuminen, R., Raissadati, A., Keränen, M. A. I., Arnaudova, R., Krebs, R., Koh, G. Y., Alitalo, K., Lemström, K. B.

“…The major cause of death during the first year after heart transplantation is primary graft dysfunction due to preservation and ischemia‐reperfusion injury…”
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Author Correction: Clonal hematopoiesis in patients with rheumatoid arthritis by Savola, Paula, Lundgren, Sofie, Keränen, Mikko A. I., Almusa, Henrikki, Ellonen, Pekka, Leirisalo-Repo, Marjatta, Kelkka, Tiina, Mustjoki, Satu

“…A Correction to this paper has been published: https://doi.org/10.1038/s41408-021-00427-1…”
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Permanent Genetic Resources added to Molecular Ecology Resources Database 1 February 2011-31 March 2011 by AUSTIN, JAMES D., BERTIN, ANGÉLINE, BÓRQUEZ, JÉSSICA P., CÁRDENAS, L., CARDOZA, TATIANA BACRY, CHAPMAN, FRANK, DE SOUSA, ADNA CRISTINA BARBOSA, DE SOUZA, ANETE PEREIRA, DOUGLAS, KORY C., ELLWOOD, SIMON R., FERRIOL, M., GARMENDIA, A., GOUIN, NICOLAS, HARGROVE, JOHN, JASTI, MADHURI, KERÄNEN, I., KNOTT, K. E., KONEC, MARJETA, KUITUNEN, K., LIMA, MARCOS PRADO, LINDE, CELESTE C., MERLE, H., OLIVA, M. E., PÉREZ, M., SAARINEN, EMILY, SAMOLLOW, PAUL B., SCARPASSA, VERA MARGARETE, SEGURA, I., SMITH, LEON, TRONTELJ, PETER, VALDIVIA, I. M., WALLWORK, HUGH, WELLENREUTHER, M.

“…This article documents the addition of 111 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following…”
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Clonal hematopoiesis in patients with rheumatoid arthritis by Savola, Paula, Lundgren, Sofie, Keränen, Mikko A. I., Almusa, Henrikki, Ellonen, Pekka, Leirisalo-Repo, Marjatta, Kelkka, Tiina, Mustjoki, Satu

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Effect of cognitive load on articulation rate and formant frequencies during simulator flights by Huttunen, Kerttu H., Keränen, Heikki I., Pääkkönen, Rauno J., Päivikki Eskelinen-Rönkä, R., Leino, Tuomo K.

“…It was explored how three types of intensive cognitive load typical of military aviation (load on situation awareness, information processing, or…”
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Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants by Raissadati, Alireza, Jokinen, Janne J, Syrjälä, Simo O, Keränen, Mikko A I, Krebs, Rainer, Tuuminen, Raimo, Arnaudova, Ralica, Rouvinen, Eeva, Anisimov, Andrey, Soronen, Jarkko, Pajusola, Katri, Alitalo, Kari, Nykänen, Antti I, Lemström, Karl

“…Heart transplant gene therapy requires vectors with long-lasting gene expression, high cardiotropism, and minimal pathological effects. Here, we examined…”
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Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts by NYKÄNEN, Antti I, SANDELIN, Henrik, ALITALO, Kari, LEMSTRÖM, Karl B, KREBS, Rainer, KERÄNEN, Mikko A. I, TUUMINEN, Raimo, KÄRPÄNEN, Terhi, YAN WU, PYTOWSKI, Bronislaw, KOSKINEN, Petri K, YLÄ-HERTTUALA, Seppo

“…Lymphatic network and chemokine-mediated signals are essential for leukocyte traffic during the proximal steps of alloimmune response. We aimed to determine…”
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Donor Simvastatin Treatment Abolishes Rat Cardiac Allograft Ischemia/Reperfusion Injury and Chronic Rejection Through Microvascular Protection by TUUMINEN, Raimo, SYRJALA, Simo, KREBS, Rainer, KERÄNEN, Mikko A. I, KOLI, Katri, ABO-RAMADAN, Usama, NEUVONEN, Pertti J, TIKKANEN, Jussi M, NYKANEN, Antti I, LEMSTRÖM, Karl B

“…Ischemia/reperfusion injury may have deleterious short- and long-term consequences for cardiac allografts. The underlying mechanisms involve microvascular…”
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Platelet-derived Growth Factor-B Protects Rat Cardiac Allografts From Ischemia-reperfusion Injury by Tuuminen, Raimo, Dashkevich, Alexey, Keränen, Mikko A I, Raissadati, Alireza, Krebs, Rainer, Jokinen, Janne J, Arnaudova, Ralica, Rouvinen, Eeva, Ylä-Herttuala, Seppo, Nykänen, Antti I, Lemström, Karl B

“…BACKGROUNDMicrovascular dysfunction and cardiomyocyte injury are hallmarks of ischemia-reperfusion injury (IRI) after heart transplantation. Platelet-derived…”
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Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity by Dufva, Olli, Koski, Jan, Maliniemi, Pilvi, Ianevski, Aleksandr, Klievink, Jay, Leitner, Judith, Pölönen, Petri, Hohtari, Helena, Saeed, Khalid, Hannunen, Tiina, Ellonen, Pekka, Steinberger, Peter, Kankainen, Matti, Aittokallio, Tero, Keränen, Mikko A.I., Korhonen, Matti, Mustjoki, Satu

“…Chimeric antigen receptor (CAR) T-cell therapy has proven effective in relapsed and refractory B-cell malignancies, but resistance and relapses still occur…”
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Angiogenic growth factors in cardiac allograft rejection by NYKÄNEN, Antti I, TIKKANEN, Jussi M, KREBS, Rainer, KERÄNEN, Mikko A. I, SIHVOLA, Roope K, SANDELIN, Henrik, TUUMINEN, Raimo, RAISKY, Olivier, KOSKINEN, Petri K, LEMSTRÖM, Karl B

“…Normal adult vasculature is in a quiescent state. In transplanted hearts, peri- and postoperative ischemic and alloimmune stimuli may be interpreted as…”
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Immunogenomic Landscape of Hematological Malignancies by Dufva, Olli, Pölönen, Petri, Brück, Oscar, Keränen, Mikko A.I., Klievink, Jay, Mehtonen, Juha, Huuhtanen, Jani, Kumar, Ashwini, Malani, Disha, Siitonen, Sanna, Kankainen, Matti, Ghimire, Bishwa, Lahtela, Jenni, Mattila, Pirkko, Vähä-Koskela, Markus, Wennerberg, Krister, Granberg, Kirsi, Leivonen, Suvi-Katri, Meriranta, Leo, Heckman, Caroline, Leppä, Sirpa, Nykter, Matti, Lohi, Olli, Heinäniemi, Merja, Mustjoki, Satu

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Somatic mutations and T-cell clonality in patients with immunodeficiency by Savola, Paula, Martelius, Timi, Kankainen, Matti, Huuhtanen, Jani, Lundgren, Sofie, Koski, Yrjö, Eldfors, Samuli, Kelkka, Tiina, Keränen, Mikko A I, Ellonen, Pekka, Kovanen, Panu E, Kytölä, Soili, Saarela, Janna, Lähdesmäki, Harri, Seppänen, Mikko R J, Mustjoki, Satu

“…Common variable immunodeficiency and other late-onset immunodeficiencies often co-manifest with autoimmunity and lymphoproliferation. The pathogenesis of most…”
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