Search Results - "Keppler, K."

Functionality of Ingredients and Additives in Plant-Based Meat Analogues by Kyriakopoulou, Konstantina, Keppler, Julia K, van der Goot, Atze Jan

“…Meat analogue research and development focuses on the production of sustainable products that recreate conventional meat in its physical sensations (texture,…”
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NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application by Trondl, Robert, Heffeter, Petra, Kowol, Christian R, Jakupec, Michael A, Berger, Walter, Keppler, Bernhard K

“…NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer and has recently been studied successfully in a…”
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Anticancer activity of metal complexes: involvement of redox processes by Jungwirth, Ute, Kowol, Christian R, Keppler, Bernhard K, Hartinger, Christian G, Berger, Walter, Heffeter, Petra

“…Cells require tight regulation of the intracellular redox balance and consequently of reactive oxygen species for proper redox signaling and maintenance of…”
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Metal Ions and Metal Complexes in Alzheimer's Disease by Spinello, Angelo, Bonsignore, Riccardo, Barone, Giampaolo, Keppler, Bernhard K, Terenzi, Alessio

“…Alzheimer's disease (AD) is the most common form of dementia that seriously affects daily life. Even if AD pathogenesis is still subject of debate, it is…”
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Protein oxidation during temperature-induced amyloid aggregation of beta-lactoglobulin by Keppler, Julia K., Heyn, Timon R., Meissner, Philipp M., Schrader, Katrin, Schwarz, Karin

“…•Amyloid aggregates at pH 2 and pH 3.5 differed in their building blocks.•All aggregate building blocks changed towards smaller peptides after >48 h…”
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Task-specific thioglycolate ionic liquids for heavy metal extraction: Synthesis, extraction efficacies and recycling properties by Platzer, Sonja, Kar, Mega, Leyma, Raphlin, Chib, Sonia, Roller, Alexander, Jirsa, Franz, Krachler, Regina, MacFarlane, Douglas R., Kandioller, Wolfgang, Keppler, Bernhard K.

“…[Display omitted] •Thioglycolate-based ionic liquids have been synthesized and their physicochemical properties have been examined.•The developed ionic liquids…”
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Nanoscale Ion-Exchange Materials: From Analytical Chemistry to Industrial and Biomedical Applications by Matczuk, Magdalena, Ruzik, Lena, Keppler, Bernhard K, Timerbaev, Andrei R

“…Nano-sized ion exchangers (NIEs) combine the properties of common bulk ion-exchange polymers with the unique advantages of downsizing into nanoparticulate…”
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An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin by Meier, Samuel M., Kreutz, Dominique, Winter, Lilli, Klose, Matthias H. M., Cseh, Klaudia, Weiss, Tamara, Bileck, Andrea, Alte, Beatrix, Mader, Johanna C., Jana, Samir, Chatterjee, Annesha, Bhattacharyya, Arindam, Hejl, Michaela, Jakupec, Michael A., Heffeter, Petra, Berger, Walter, Hartinger, Christian G., Keppler, Bernhard K., Wiche, Gerhard, Gerner, Christopher

“…Organometallic metal(arene) anticancer agents require ligand exchange for their anticancer activity and this is generally believed to confer low selectivity…”
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Analysis of Engineered Nanoparticles in Seawater Using ICP-MS-Based Technology: From Negative to Positive Samples by Kuznetsova, Olga V, Keppler, Bernhard K, Timerbaev, Andrei R

“…A growing global emission of engineered nanoparticles (ENPs) into the aquatic environment has become an emerging safety concern that requires methods capable…”
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KP1019, A New Redox-Active Anticancer Agent - Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients by Hartinger, Christian G., Jakupec, Michael A., Zorbas-Seifried, Stefanie, Groessl, Michael, Egger, Alexander, Berger, Walter, Zorbas, Haralabos, Dyson, Paul J., Keppler, Bernhard K.

“…The promising drug candidate indazolium trans‐[tetrachlorobis(1H‐indazole)ruthenate(III)] (KP1019) is the second Ru‐based anticancer agent to enter clinical…”
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Antitumour metal compounds: more than theme and variations by Jakupec, Michael A, Galanski, Markus, Arion, Vladimir B, Hartinger, Christian G, Keppler, Bernhard K

“…Triggered by the resounding success of cisplatin, the past decades have seen tremendous efforts to produce clinically beneficial analogues. The recent…”
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From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1 H-indazole)ruthenate(III)] (KP1019 or FFC14A) by Hartinger, Christian G., Zorbas-Seifried, Stefanie, Jakupec, Michael A., Kynast, Bernd, Zorbas, Haralabos, Keppler, Bernhard K.

“…Indazolium trans-[tetrachlorobis(1 H-indazole)ruthenate(III)] (KP1019 or FFC14A) is just the second ruthenium-based anticancer agent after NAMI-A which was…”
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Influence of the polydispersity of pH 2 and pH 3.5 beta-lactoglobulin amyloid fibril solutions on analytical methods by Heyn, Timon R., Garamus, Vasil M., Neumann, Hendrikje R., Uttinger, Maximilian J., Guckeisen, Tobias, Heuer, Monique, Selhuber-Unkel, Christine, Peukert, Wolfgang, Keppler, Julia K.

“…[Display omitted] •pH 2 and pH 3.5 amyloid aggregate solution differ in their polydispersity.•Mixtures of amyloid and non-amyloids were compared with separated…”
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Update of the Preclinical Situation of Anticancer Platinum Complexes: Novel Design Strategies and Innovative Analytical Approaches by Galanski, Mathea Sophia, Jakupec, Michael A, Keppler, Bernhard K

“…Research in the field of bioinorganic chemistry has been stimulated by the worldwide success of the anticancer drug cisplatin. 40 years after the first report…”
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Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis‐1,8‐naphthalimide Ligands by Streciwilk, Wojciech, Terenzi, Alessio, Lo Nardo, Federico, Prochnow, Pascal, Bandow, Julia Elisabeth, Keppler, Bernhard K., Ott, Ingo

“…Organometallic N‐heterocyclic carbene (NHC) complexes with intercalating bis‐naphthalimide ligands were prepared and evaluated biologically. Cytotoxic effects…”
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Ionic liquids for extraction of metals and metal containing compounds from communal and industrial waste water by Fischer, Lisa, Falta, Thomas, Koellensperger, Gunda, Stojanovic, Anja, Kogelnig, Daniel, Galanski, Mathea S., Krachler, Regina, Keppler, Bernhard K., Hann, Stephan

“…In a fundamental study the potential of ionic liquids based on quaternary ammonium- and phosphonium cations and thiol-, thioether-, hydroxyl-, carboxylate- and…”
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Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans by Fangmann, Daniela, Theismann, Eva-Maria, Türk, Kathrin, Schulte, Dominik M, Relling, Isabelle, Hartmann, Katharina, Keppler, Julia K, Knipp, Jörg-Rainer, Rehman, Ateequr, Heinsen, Femke-Anouska, Franke, Andre, Lenk, Lennart, Freitag-Wolf, Sandra, Appel, Esther, Gorb, Stanislav, Brenner, Charles, Seegert, Dirk, Waetzig, Georg H, Rosenstiel, Philip, Schreiber, Stefan, Schwarz, Karin, Laudes, Matthias

“…Gut microbiota represent a potential novel target for future prediabetes and type 2 diabetes therapies. In that respect, niacin has been shown to beneficially…”
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Structure−Activity Relationships for NAMI-A-type Complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl-1,2,4-triazole):  Aquation, Redox Properties, Protein Binding, and Antiproliferative Activity by Groessl, Michael, Reisner, Erwin, Hartinger, Christian G, Eichinger, Rene, Semenova, Olga, Timerbaev, Andrei R, Jakupec, Michael A, Arion, Vladimir B, Keppler, Bernhard K

“…Imidazolium [trans-tetrachloro(1H-imidazole)(S-dimethylsulfoxide)ruthenate(III)] (NAMI-A) and indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)]…”
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Offering HCV treatment to prisoners is an important opportunity: key principles based on policy and practice assessment in Europe by Stöver, H, Meroueh, F, Marco, A, Keppler, K, Saiz de la Hoya, P, Littlewood, R, Wright, N, Nava, F, Alam, F, Walcher, S, Somaini, L

“…Prisoners have a high prevalence of hepatitis C virus (HCV) infection but may find it difficult to access healthcare services. This may be related to risk…”
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Ruthenium-arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition by Hager, Laura A, Mokesch, Stephan, Kieler, Claudia, Alonso-de Castro, Silvia, Baier, Dina, Roller, Alexander, Kandioller, Wolfgang, Keppler, Bernhard K, Berger, Walter, Salassa, Luca, Terenzi, Alessio

“…Quadruplex nucleic acids - DNA/RNA secondary structures formed in guanine rich sequences - proved to have key roles in the biology of cancers and, as such, in…”
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