Search Results - "Keppel, Dorottya"

Abstract 944: Pre-clinical activity of the Wnt pathway inhibitor RXC004 in combination with MAPK pathway inhibitors in GI cancer models by Woodcock, Simon A., Keppel, Dorottya, Eagle, Catherine, Kelly, James, Flanagan, Eimear, Bishop, Emma, Bhamra, Inder, Jones, Clifford D., Armer, Richard, Robertson, Jane, Phillips, Caroline

“…Abstract Background: Gastrointestinal (GI) cancers cause more cancer deaths than any other body system, with 3.4 million related deaths in 2018. Wnt pathway…”
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Abstract 1654: Pre-clinical activity of the Wnt/Beta-catenin pathway inhibitor RXC004 in models of biliary tract cancer by Woodcock, Simon A., Keppel, Dorottya, Eagle, Catherine, Bhamra, Inder, Platt, Eleanor, Frost, Lucy, Randall, Kevin, Armer, Richard, Robertson, Jane, Marshall, Gayle, Phillips, Caroline

“…Abstract Background: RXC004 is a potent and selective inhibitor of the Wnt pathway regulator Porcupine, and is currently being investigated in phase 2 studies…”
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Abstract 2677: JZP815, a potent and selective pan-RAF inhibitor, demonstrates efficacy in RAF and RAS mutant tumor pre-clinical models by Hauptschein, Robert, Woodcock, Simon, Belfield, Andrew, Mason, Helen, Keppel, Dorottya, Markova, Svetlana, Kim, Kyuri, Roller, Shane, Phillips, Caroline, Jones, Clifford D., Humphreys, Robin C.

“…Abstract Activation of the mitogen-activated protein kinase (MAPK) pathway by oncogenic mutations in RAS and RAF is a frequent driver of human cancer…”
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