Search Results - "Kepler, J A"

Simple stiffness tailoring of balsa sandwich core material by Kepler, J.A.

“…A concept for improving the shear stiffness properties of balsa core material for sandwich structures is presented. The concept is based on utilization of the…”
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Behaviour of multiple composite plates subjected to ballistic impact by Sheikh, A.H., Bull, P.H., Kepler, J.A.

“…An experimental and numerical investigation has been carried out to study the behavior of single and multiple laminated panels subjected to ballistic impact. A…”
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Characterization of the interaction of cryptophycin 1 with tubulin : Binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction by BAI, R, SCHWARTZ, R. E, KEPLER, J. A, PETTIT, G. R, HAMEL, E

“…The antimitotic depsipeptide cryptophycin 1 (CP1) was compared to the antimitotic peptide dolastatin 10 (D10) as an antiproliferative agent and in its…”
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Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions by Bai, R, Taylor, G F, Schmidt, J M, Williams, M D, Kepler, J A, Pettit, G R, Hamel, E

“…We have prepared [3H]dolastatin 10 and examined its interactions with tubulin. Binding kinetics appeared to be biphasic, with a rapid initial reaction that…”
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Numerical Modeling of Sandwich Panel Response to Ballistic Loading — Energy Balance for Varying Impactor Geometries by Kepler, J.A., Hansen, M.R.

“…A sandwich panel is described by an axisymmetric lumped mass— spring model. The panel compliance is simplified, considering only core shear deformation…”
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In vivo labeling of neuronal nicotinic acetylcholine receptors with radiolabeled isomers of norchloroepibatidine by Scheffel, U, Taylor, G F, Kepler, J A, Carroll, F I, Kuhar, M J

“…In vitro binding studies have shown that epibatidine and its norchloro analogues have high affinities for the cholinergic nicotinic receptor. In this study,…”
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1,2,4-Trioxanes as potential antimalarial agents by Kepler, John A, Philip, Abraham, Lee, Y. W, Morey, Matthew C, Carroll, F. Ivy

“…A number of 1,2,4-trioxanes were prepared and tested for antimalarial activity in search of a simplified analogue of the naturally occurring antimalarial…”
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Synthesis of carbon-14 labeled 1-(2-hydroxyiminomethyl)-1-pyridino-3-(4-carbamoyl-1-pyridino)-2-oxapropane dichloride monohydrate ([14C]HI-6 · H2O) by Amin, M., Twine, C. E., Kepler, J. A.

“…The synthesis of the title compound ([14C]‐2) is described. Simultaneous quaternizations of 2‐pyridine[14C]aldoxime (8) and isonicotin‐amide (10) by…”
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The Spongistatins, Potently Cytotoxic Inhibitors of Tubulin Polymerization, Bind in a Distinct Region of the Vinca Domain by Bai, Ruoli, Taylor, George F, Cichacz, Zbigniew A, Herald, Cherry L, Kepler, John A, Pettit, George R, Hamel, Ernest

“…The highly cytotoxic, sponge-derived, antimitotic macrolide polyether spongistatin 1 has been previously shown to inhibit microtubule assembly, the binding of…”
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Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity by Verdier-Pinard, P, Kepler, J A, Pettit, G R, Hamel, E

“…Dolastatin 10 is a highly cytotoxic antimitotic peptide in phase II clinical trials. Its cytotoxicity has been as much as 50-fold greater than that of…”
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Caffeine in plasma and saliva by a radioimmunoassay procedure by Cook, C E, Tallent, C R, Amerson, E W, Myers, M W, Kepler, J A, Taylor, G F, Christensen, H D

“…Caffeine was analyzed in human plasma and saliva by a simple, rapid, and sensitive radioimmunoassay procedure. Immunization of rabbits with an antigen prepared…”
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Endoperoxides as potential antimalarial agents by Kepler, John A, Philip, Abraham, Lee, Y. W, Musallam, H. A, Carroll, F. Ivy

“…A number of mono- and bicyclic endoperoxides were prepared and tested for antimalarial activity in search of a simplified analogue of the 5-oxygen-substituted…”
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Plant antitumor agents. IX. Total synthesis of dl-camptothecin by Wani, M. C, Campbell, H. F, Brine, G. A, Kepler, J. A, Wall, Monroe E, Levine, S. G

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The Structure of Fomannosin, a Novel Sesquiterpene Metabolite of the Fungus Fomes annosus by Kepler, J. A, Wall, Monroe E, Mason, J. E, Basset, C, McPhail, A. T, Sim, G. A

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Plant antitumor agents. IV. An approach toward the synthesis of camptothecin by Kepler, J. A, Wani, M. C, McNaull, J. N, Wall, Monroe E, Levine, Samuel Gale

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Behaviour of multiple composite plates subjected to ballistic impact: ONR - Dynamic Failure and Durability by SHEIKH, A. H, BULL, P. H, KEPLER, J. A

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Synthesis of [14C]Azodicarbonamide by Hristova-Kazmierski, Maria K., Kepler, John A.

“…[14C]Azodicarbonamide, a potent inhibitor of HIV‐1 and HIV‐2 was prepared by reaction of hydrazine sulfate with potassium [14C]cyanate, followed by oxidation…”
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The preparation of stereospecific tritium-labeled reduced nicotinamide adenine dinucleotide phosphate by Freudenthal, R I, Kepler, J A, Cook, C E

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Peptide derivatives of primaquine as potential antimalarial agents by Philip, A, Kepler, J A, Johnson, B H, Carroll, F I

“…Three peptide derivatives of primaquine were synthesized. The compounds were tested for radical curative antimalarial activity against Plasmodium cynomolgi in…”
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Reaction of the Trichloromethyl Group with Di- and Trialkyl Phosphites by Kepler, J. A, Carroll, F. I, Garner, R. A, Wall, M. E

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