Evaluation of Outcomes in Patients Given Dexmedetomidine in Functional Endoscopic Sinus Surgery

Objectives: We aimed to evaluate the effects of dexmedetomidine hydrochloride (DEX) on hemodynamic parameters and on surgeon and patient satisfaction during functional endoscopic sinus surgery (FESS). Methods: Forty patients who were to undergo FESS were enrolled in this randomized, prospective, con...

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Bibliographic Details
Published in:	Annals of otology, rhinology & laryngology Vol. 120; no. 9; pp. 586 - 592
Main Authors:	Guven, Damla Guclu, Demiraran, Yavuzw, Sezen, Gulbin, Kepek, Okkes, Iskender, Abdulkadir
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-09-2011 Annals Publishing Compagny SAGE PUBLICATIONS, INC
Subjects:	Adolescent Adrenergic alpha-2 Receptor Agonists - adverse effects Adrenergic alpha-2 Receptor Agonists - therapeutic use Adult Biological and medical sciences Blood Loss, Surgical - prevention & control Chronic Disease Conscious Sedation Dexmedetomidine - adverse effects Dexmedetomidine - therapeutic use Endoscopy Female Heart Rate - drug effects Hemodynamics - drug effects Humans Male Medical sciences Middle Aged Otorhinolaryngology. Stomatology Paranasal Sinuses - surgery Prospective Studies Sinusitis - surgery Treatment Outcome dexmedetomidine intraoperative bleeding hemodynamic stability FESS functional endoscopic sinus surgery α2-Adrenergic receptor Human Endoscopic surgery Evaluation Agonist Prognosis Stability Intraoperative ENT Hemorrhage Treatment Dexmedetomidine α-Adrenergic receptor agonist Hemodynamics
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Summary:	Objectives: We aimed to evaluate the effects of dexmedetomidine hydrochloride (DEX) on hemodynamic parameters and on surgeon and patient satisfaction during functional endoscopic sinus surgery (FESS). Methods: Forty patients who were to undergo FESS were enrolled in this randomized, prospective, controlled study. In the DEX group, conscious sedation was induced with an infusion of 1 μg/kg of DEX 10 minutes before surgery, followed by an infusion of DEX at 0.2 μg/kg per hour. A control group was given identical amounts of saline solution. During the procedure, hemodynamic data were recorded. The patients evaluated their pain on a visual analog scale (VAS). Intraoperative bleeding was rated on a 6-point scale for evaluation of operative field visibility. Results: We observed that the DEX group had lower bleeding scores (p = 0.019). The heart rates were lower in the DEX group at the time of induction (p = 0.052) and in the 1st (p = 0.009) and 20th minutes (p = 0.039) of induction. The mean blood pressure values were lower in the DEX group in the 5th (p < 0.001), 45th (p = 0.003), and 60th (p = 0.05) minutes of induction. The VAS score was lower in the DEX group in the 30th postoperative minute (p = 0.001); however, the VAS score was lower in the control group after the 12th hour (p < 0.001). Postoperative side effects such as nausea, tachycardia, hypotension, and vomiting were significantly less frequent in the DEX group (p < 0.001). Conclusions: We observed that the intraoperative bleeding, hemodynamic stability, and VAS scores were better and the side effects were less frequent in the DEX group.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0003-4894 1943-572X
DOI:	10.1177/000348941112000906