Search Results - "Keohavong, Phouthone"

Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons by Shvedova, Anna A, Yanamala, Naveena, Kisin, Elena R, Tkach, Alexey V, Murray, Ashley R, Hubbs, Ann, Chirila, Madalina M, Keohavong, Phouthone, Sycheva, Lyudmila P, Kagan, Valerian E, Castranova, Vincent

“…The hallmark geometric feature of single-walled carbon nanotubes (SWCNT) and carbon nanofibers (CNF), high length to width ratio, makes them similar to a…”
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Aberrant Promoter Methylation of p16 and MGMT Genes in Lung Tumors from Smoking and Never-Smoking Lung Cancer Patients by Liu, Yang, Lan, Qing, Siegfried, Jill M., Luketich, James D., Keohavong, Phouthone

“…Aberrant methylation in gene promoter regions leads to transcriptional inactivation of cancer-related genes and plays an integral role in tumorigenesis. This…”
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Molecular analysis of mutations in the human HPRT gene by Keohavong, Phouthone, Xi, Liqiang, Grant, Stephen G

“…The HPRT assay uses incorporation of toxic nucleotide analogues to select for cells lacking the purine scavenger enzyme hypoxanthine-guanine phosphoribosyl…”
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Analysis of p53 mutations in histologically normal lung tissues and lung tumors from non-small cell lung cancer patients by Gao, Weimin, Mady, Hussam H., Melhem, Mona F., Keohavong, Phouthone

“…Our previous study showed a characteristic p53 mutational spectrum in lung tumors from lung cancer patients in the Western Pennsylvania region. To further…”
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Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis by Stabile, Laura P, Rothstein, Mary E, Keohavong, Phouthone, Jin, Jide, Yin, Jinling, Land, Stephanie R, Dacic, Sanja, Luong, The Minh, Kim, K Jin, Dulak, Austin M, Siegfried, Jill M

“…The hepatocyte growth factor (HGF)/c-Met signaling pathway is involved in lung tumor growth and progression, and agents that target this pathway have clinical…”
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Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice by Stabile, Laura P, Rothstein, Mary E, Keohavong, Phouthone, Lenzner, Diana, Land, Stephanie R, Gaither-Davis, Autumn L, Kim, K Jin, Kaminski, Naftali, Siegfried, Jill M

“…EGFR and c-Met are both overexpressed in lung cancer and initiate similar downstream signaling, which may be redundant. To determine how frequently ligands…”
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Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers by Liu, Yang, Gao, Weimin, Siegfried, Jill M, Weissfeld, Joel L, Luketich, James D, Keohavong, Phouthone

“…Epidemiological studies indicate that some characteristics of lung cancer among never-smokers significantly differ from those of smokers. Aberrant promoter…”
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Aberrant Gene Promoter Methylation in Sputum from Individuals Exposed to Smoky Coal Emissions by YANG LIU, QING LAN, MIN SHEN, JIDE JIN, MUMFORD, Judy, DIANXU REN, KEOHAVONGI, Phouthone

“…Background: Recent studies suggested the potential for aberrant gene promoter methylation in sputum as a predictive marker for lung cancer. Here, the promoter…”
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Polymorphisms in the DNA Base Excision Repair Genes APEX1 and XRCC1 and Lung Cancer Risk in Xuan Wei, China by Shen, Min, Berndt, Sonja I, Rothman, Nathaniel, Mumford, Judy L, He, Xingzhou, Yeager, Meredith, Welch, Robert, Chanock, Stephen, Keohavong, Phouthone, Donahue, Mark, Zheng, Tongzhang, Caporaso, Neil, Lan, Qing

“…The lung cancer mortality rate in Xuan Wei is among the highest in China and has been causally attributed to high exposure to indoor smoky coal emissions,…”
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Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China by Lan, Qing, Shen, Min, Berndt, Sonja I., Bonner, Matthew R., He, Xingzhou, Yeager, Meredith, Welch, Robert, Keohavong, Phouthone, Donahue, Mark, Hainaut, Pierre, Chanock, Stephen

“…Lung cancer rates in Xuan Wei County are among the highest in China and have been associated with exposure to indoor smoky coal emissions that contain high…”
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Comparison of Mutations in the p53 and K-ras Genes in Lung Carcinomas from Smoking and Nonsmoking Women by Gealy, R, Zhang, L, Siegfried, J M, Luketich, J D, Keohavong, P

“…Lung cancer incidence is increasing in women with little or no tobacco exposure, and the cause of this trend is not known. One possibility is increased…”
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Fidelity of DNA Polymerases in DNA Amplification by Keohavong, Phouthone, Thilly, William G.

“…Denaturing gradient gel electrophoresis (DGGE) was used to separate and isolate the products of DNA amplification by polymerase chain reaction (PCR). The…”
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Detection of K-ras mutations in lung carcinomas: relationship to prognosis by PHOUTHONE KEOHAVONG, DEMICHELE, M. A. A, MELACRINOS, A. C, LANDRENEAU, R. J, WEYANT, R. J, SIEGFRIED, J. M

“…The K-ras mutation is one of the most common genetic alterations found in human lung cancer. To evaluate the prognostic value of ras gene alterations in lung…”
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Lipopolysaccharide-Mediated Chronic Inflammation Promotes Tobacco Carcinogen-Induced Lung Cancer and Determines the Efficacy of Immunotherapy by Liu, Chia-Hsin, Chen, Zhong, Chen, Kong, Liao, Fu-Tien, Chung, Chia-En, Liu, Xiaoping, Lin, Yu-Chun, Keohavong, Phouthone, Leikauf, George D, Di, Yuanpu Peter

“…Chronic obstructive pulmonary disease (COPD) is an inflammatory disease that is associated with increased risk of lung cancer. (PA) infections are frequent in…”
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Overexpression of CRM1: A Characteristic Feature in a Transformed Phenotype of Lung Carcinogenesis and a Molecular Target for Lung Cancer Adjuvant Therapy by Gao, Weimin, Lu, Chuanwen, Chen, Lixia, Keohavong, Phouthone

“…Our previous study showed that chromosome region maintenance 1 (CRM1), a nuclear export receptor for various cancer-associated "cargo" proteins, was important…”
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p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China by Keohavong, Phouthone, Lan, Qing, Gao, Weimin

“…•Female nonsmokers in Xuan Wei County, China, were exposed to smoky coal combustion.•These women developed lung cancer at a rate higher than the Chinese…”
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Detection of point mutations of K-ras oncogene and p53 tumor-suppressor gene in sputum samples by Gao, Weimin, Keohavong, Phouthone

“…Mutations in the p53 tumor-suppressor gene and K-ras oncogene have been frequently found in sputum and bronchoalveolar lavage samples of lung cancer patients…”
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Pulmonary Inflammation and KRAS Mutation in Lung Cancer by Keohavong, Phouthone, Peter Di, Y

“…Chronic lung infection and lung cancer are two of the most important pulmonary diseases. Respiratory infection and its associated inflammation have been…”
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Sequence‐dependent cleavage of mismatched DNA by Ban I restriction endonuclease by Gao, Weimin, Zhu, Dan, Keohavong, Phouthone

“…Restriction enzymes have previously shown the ability to cleave DNA substrates with mismatched base(s) in recognition sequences; in this study, Ban I…”
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Inflammation synergistically promotes cigarette smoke carcinogen-induced lung tumorigenesis and determines immunotherapy efficacy by Di, Yuanpu Peter, Liu, Chia-Hsin, Chen, Zhong, Chen, Kong, Liao, Fu-Tien, Keohavong, Phouthone, Leikauf, George

“…Abstract Chronic obstructive pulmonary disease (COPD) is a chronic lung inflammatory disease with an increased risk of lung cancer. Pseudomonas aeruginosa (PA)…”
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