Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke

Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke

Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood-brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of occludin research, a key tight ju...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity Vol. 2024; no. 1; p. 2121733
Main Authors: Urasheva, Zhanylsyn U, Kabdrakhmanova, Gulnar B, Yermagambetova, Aigul P, Utegenova, Aigerim B, Seitmaganbetova, Nazgul A, Aliyev, Ondassyn M, Kurmangaliyeva, Saulesh S, Kenzhina, Nazym K, Kurmambayev, Yergen Z, Khamidulla, Alima A
Format: Journal Article
Language:English
Published: United States Hindawi Limited 2024
Wiley
Subjects:
Animals
Bibliometrics
Blood-Brain Barrier - metabolism
Brain research
Citations
Collaboration
Humans
Ischemia
Keywords
Occludin - metabolism
Pathogenesis
Pathology
Permeability
Review
Software
Stroke - metabolism
Trends
Kazakhstan
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Summary:Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood-brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of occludin research, a key tight junction protein, during the years 2000-2023, shedding light on the global scientific contributions, collaborations, and emerging trends in this critical area of stroke pathogenesis. China and the United States emerge as significant contributors, underscoring their prominence in advancing our understanding of tight junction proteins. Occludin, identified as a linchpin in regulating BBB integrity, proves to be a pivotal player, with implications extending to the diagnosis of hemorrhagic transformation in ischemic stroke. This study identifies occludin as a potential biomarker, offering promise for early diagnosis and paving the way for novel diagnostic strategies. The analysis highlights the necessity for a more comprehensive exploration of tight junction proteins, including occludin and claudin-5, particularly in the context of acute cerebral ischemia. The unique healthcare landscape in Kazakhstan adds urgency to the call for further scientific research in this region, emphasizing the need for tailored investigations to address specific regional challenges. This comprehensive overview not only delineates the current state of occludin research but also signals the direction for future investigations. The identified knowledge gaps and emerging trends provide a roadmap for researchers and policymakers alike, with implications for both scientific discourse and clinical practice. Moving forward, a deeper understanding of tight junction proteins, informed by the insights gleaned from this study, holds the potential to shape targeted therapeutic interventions and diagnostic strategies, ultimately contributing to advancements in global stroke care.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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Academic Editor: Maurizio Forte
ISSN:1942-0900
1942-0994
1942-0994
DOI:10.1155/2024/2121733