Search Results - "Kenyon, G L"

Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents by Andricopulo, A.D., Akoachere, M.B., Krogh, R., Nickel, C., McLeish, M.J., Kenyon, G.L., Arscott, L.D., Williams, C.H., Davioud-Charvet, E., Becker, K.

“…Uncompetitive inhibition of Plasmodium falciparum thioredoxin reductase by nitrophenyl derivatives. Plasmodium falciparum thioredoxin reductase (PfTrxR: NADPH…”
Get full text

Optimizing the Binding of Fullerene Inhibitors of the HIV-1 Protease through Predicted Increases in Hydrophobic Desolvation by Friedman, Simon H, Ganapathi, Padma S, Rubin, Yves, Kenyon, George L

“…We have developed and applied a computational strategy to increase the affinity of fullerene-based inhibitors of the HIV protease. The result is a ∼50-fold…”
Get full text

Inhibition of the HIV-1 protease by fullerene derivatives: model building studies and experimental verification by Friedman, Simon H, DeCamp, Dianne L, Sijbesma, Rint P, Srdanov, Gordana, Wudl, Fred, Kenyon, George L

“…The ability of C sub(60) fullerene ("Bucky Ball") derivatives to interact with the active site of HIV-1 protease (HIVP) has been examined through model…”
Get full text

In Vitro Antimalarial Activity of Chalcones and Their Derivatives by Li, Rongshi, Kenyon, George L, Cohen, Fred E, Chen, Xiaowu, Gong, Baoqing, Dominguez, Jose N, Davidson, Eugene, Kurzban, Gary, Miller, Robert E, Nuzum, Edwin O, Rosenthal, Philip J, McKerrow, James H

“…A series of chalcones and their derivatives have been synthesized and identified as novel potential antimalarials using both molecular modeling and in vitro…”
Get full text

Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei by Troeberg, L, Chen, X, Flaherty, T M, Morty, R E, Cheng, M, Hua, H, Springer, C, McKerrow, J H, Kenyon, G L, Lonsdale-Eccles, J D, Coetzer, T H, Cohen, F E

“…Protozoan parasites of the genus Trypanosoma cause disease in a wide range of mammalian hosts. Trypanosoma brucei brucei, transmitted by tsetse fly to cattle,…”
Get full text

A functionally diverse enzyme superfamily that abstracts the α protons of carboxylic acids by BABBITT, P. C, MRACHKO, G. T, HASSON, M. S, HUISMAN, G. W, KOLTER, R, RINGE, D, PETSKO, G. A, KENYON, G. L, GERLT, J. A

“…Mandelate racemase and muconate lactonizing enzyme are structurally homologous but catalyze different reactions, each initiated by proton abstraction from…”
Get full text

Spectroscopic Detection of Transient Thiamin Diphosphate-Bound Intermediates on Benzoylformate Decarboxylase by Sergienko, Eduard A, Wang, Jue, Polovnikova, Lena, Hasson, Miriam S, McLeish, Michael J, Kenyon, George L, Jordan, Frank

“…Thiamin diphosphate (ThDP)-dependent enzymes catalyze a range of transformations, such as decarboxylation and ligation. We report a novel spectroscopic assay…”
Get full text

4-Oxalocrotonate tautomerase, an enzyme composed of 62 amino acid residues per monomer by CHEN, L. H, KENYON, G. L, CURTIN, F, HARAYAMA, S, BEMBENEK, M. E, GHOLAMHOSSEIN HAJIPOUR, WHITMAN, C. P

“…The xylH gene encoding 4-oxalocrotonate tautomerase (4-OT) has been located on a subclone of the Pseudomonas putida mt-2 TOL plasmid pWW0 and inserted into an…”
Get full text

Mutagenesis of Two Acidic Active Site Residues in Human Muscle Creatine Kinase:  Implications for the Catalytic Mechanism by Cantwell, John S, Novak, Walter R, Wang, Pan-Fen, McLeish, Michael J, Kenyon, George L, Babbitt, Patricia C

“…Creatine kinase (CK) catalyzes the reversible phosphorylation of the guanidine substrate, creatine, by MgATP. Although several X-ray crystal structures of…”
Get full text

Structural identification of autoinducer of Photobacterium fischeri luciferase by Eberhard, A, Burlingame, A. L, Eberhard, C, Kenyon, G. L, Nealson, K. H, Oppenheimer, N. J

“…Synthesis of bacterial luciferase in some strains of luminous bacteria requires a threshold concentration of an autoinducer synthesized by the bacteria and…”
Get full text

Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases by Babbitt, Patricia C, Kenyon, George L, Martin, Brian M, Charest, Hugues, Slyvestre, Michel, Scholten, Jeffrey D, Chang, Kai Hsuan, Liang, Po Huang, Dunaway-Mariano, Debra

“…We have deduced the nucleotide sequence of the genes encoding the three components of 4-chlorobenzoate (4-CBA) dehalogenase from Pseudomonas sp. CBS-3 and…”
Get full text

The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: Mechanistic and crystallographic evidence for stereospecific alkylation by (R)-.alpha.-phenylglycidate by Landro, James A, Gerlt, John A, Kozarich, John W, Koo, Carolyn W, Shah, Vibhakar J, Kenyon, George L, Neidhart, David J, Fujita, Shigeo, Petsko, Gregory A

“…The mechanism of irreversible inactivation of mandelate racemase (MR) from Pseudomonas putida by alpha-phenylglycidate (alpha PGA) has been investigated…”
Get full text

The active site of creatine kinase. Affinity labeling of cysteine 282 with N-(2,3-epoxypropyl)-N-amidinoglycine by Buechter, D D, Medzihradszky, K F, Burlingame, A L, Kenyon, G L

“…Epoxycreatine (N-(2,3-epoxypropyl)-N-amidinoglycine) is an affinity label of creatine kinase that irreversibly and completely inactivates the enzyme (Marletta,…”
Get full text

Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli by Tsou, Amy Y, Ransom, Stephen C, Gerlt, John A, Buechter, Douglas D, Babbitt, Patricia C, Kenyon, George L

“…The genes that encode the five known enzymes of the mandelate pathway of Pseudomonas putida (ATCC 12633), mandelate racemase (mdlA), (S)-mandelate…”
Get full text

Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous by Neidhart, David J, Kenyon, George L, Gerlt, John A, Petsko, Gregory A

“…Mandelate racemase (MR) and muconate lactonizing enzyme (MLE) catalyse separate and mechanistically distinct reactions necessary for the catabolism of aromatic…”
Get full text

Sequence Verification of Human Creatine Kinase (43 kDa) Isozymes by High- Resolution Tandem Mass Spectrometry by Wood, Troy D., Chen, Lorenzo H., White, Camille B., Babbitt, Patricia C., Kenyon, George L., McLafferty, Fred W.

“…Amino acid sequencing by recombinant DNA technology, although dramatically useful, is subject to base reading errors, is indirect, and is insensitive to…”
Get full text

The crystal structure of benzoylformate decarboxylase at 1.6 Angstrom resolution: Diversity of catalytic residues in thiamin diphosphate-dependent enzymes by Hasson, MS, Muscate, A, McLeish, MJ, Polovnikova, L S, Gerlt, JA, Kenyon, G L, Petsko, G A, Ringe, D

“…The crystal structure of the thiamin diphosphate (ThDP)-dependent enzyme benzoylformate decarboxylase (BFD), the third enzyme in the mandelate pathway of…”
Get full text

Exchanging the substrate specificities of pyruvate decarboxylase from Zymomonas mobilis and benzoylformate decarboxylase from Pseudomonas putida by Siegert, Petra, McLeish, Michael J., Baumann, Martin, Iding, Hans, Kneen, Malea M., Kenyon, George L., Pohl, Martina

“…Pyruvate decarboxylase from Zymomonas mobilis (PDC) and benzoylformate decarboxylase from Pseudomonas putida (BFD) are thiamine diphosphate-dependent enzymes…”
Get full text

An Unusually Low pK a for Cys282 in the Active Site of Human Muscle Creatine Kinase by Wang, Pan-Fen, McLeish, Michael J, Kneen, Malea M, Lee, Gavin, Kenyon, George L

“…All phosphagen kinases contain a conserved cysteine residue which has been shown by crystallographic studies, on both creatine kinase and arginine kinase, to…”
Get full text

The Enolase Superfamily:  A General Strategy for Enzyme-Catalyzed Abstraction of the α-Protons of Carboxylic Acids by Babbitt, Patricia C, Hasson, Miriam S, Wedekind, Joseph E, Palmer, David R. J, Barrett, William C, Reed, George H, Rayment, Ivan, Ringe, Dagmar, Kenyon, George L, Gerlt, John A

“…We have discovered a superfamily of enzymes related by their ability to catalyze the abstraction of the α-proton of a carboxylic acid to form an enolic…”
Get full text