Search Results - "Kenyon, Elaina M"

Arsenic toxicokinetic modeling and risk analysis: Progress, needs and applications by Kenyon, Elaina M.

“…Arsenic (As) poses unique challenges in PBTK model development and risk analysis applications. Arsenic metabolism is complex, adequate information to attribute…”
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Genome-wide Analysis of DNA Methylation and Gene Expression Changes in the Mouse Lung following Subchronic Arsenate Exposure by Boellmann, Frank, Zhang, Lu, Clewell, Harvey J., Schroth, Gary P., Kenyon, Elaina M., Andersen, Melvin E., Thomas, Russell S.

“…Alterations in DNA methylation have been proposed as a mechanism for the complex toxicological effects of arsenic. In this study, whole-genome DNA methylation…”
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A concise review of the toxicity and carcinogenicity of dimethylarsinic acid by Kenyon, Elaina M., Hughes, Michael F.

“…Dimethylarsinic acid (DMA) has been used as a herbicide (cacodylic acid) and is the major metabolite formed after exposure to tri- (arsenite) or pentavalent…”
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Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate by Hughes, Michael F, Kenyon, Elaina M, Edwards, Brenda C, Mitchell, Carol T, Razo, Luz Maria Del, Thomas, David J

“…Exposure to the human carcinogen inorganic arsenic (iAs) occurs daily. However, the disposition of arsenic after repeated exposure is not well known. This…”
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Corrigendum to ’Comparison of In Vivo Derived and Scaled In Vitro Metabolic Rate Constants for Several Volatile Organic Compounds (VOCs)’ [toxicology in vitro 68 (2020) start page–end page] by Kenyon, Elaina M., Eklund, Christopher, Pegram, Rex A., Lipscomb, John C.

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Comparison of in vivo derived and scaled in vitro metabolic rate constants for several volatile organic compounds (VOCs) by Kenyon, Elaina M., Eklund, Christopher, Pegram, Rex A., Lipscomb, John C.

“…Metabolic rate parameters estimation using in vitro data is necessary due to numbers of chemicals for which data are needed, trend towards minimizing…”
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Development and application of a human PBPK model for bromodichloromethane to investigate the impacts of multi-route exposure by Kenyon, Elaina M., Eklund, Christopher, Leavens, Teresa, Pegram, Rex A.

“…As a result of its presence in water as a volatile disinfection byproduct, bromodichloromethane (BDCM), which is mutagenic, poses a potential health risk from…”
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Genomic comparisons between hepatocarcinogenic and non-hepatocarcinogenic organophosphate insecticides in the mouse liver by Rooney, John, Wehmas, Leah C., Ryan, Natalia, Chorley, Brian N., Hester, Susan D., Kenyon, Elaina M., Schmid, Judith E., George, Barbara Jane, Hughes, Michael F., Sey, Yusupha M., Tennant, Alan H., Simmons, Jane Ellen, Wood, Charles E., Corton, J. Christopher

“…Short-term biomarkers of toxicity have an increasingly important role in the screening and prioritization of new chemicals. In this study, we examined early…”
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The Impact of Scaling Factor Variability on Risk-Relevant Pharmacokinetic Outcomes in Children: A Case Study Using Bromodichloromethane (BDCM) by Kenyon, Elaina M, Lipscomb, John C, Pegram, Rex A, George, Barbara J, Hines, Ronald N

“…Abstract Biotransformation rates extrapolated from in vitro data are used increasingly in human physiologically based pharmacokinetic (PBPK) models. This…”
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From the Cover: Genomic Effects of Androstenedione and Sex-Specific Liver Cancer Susceptibility in Mice by Rooney, John P, Ryan, Natalia, Chorley, Brian N, Hester, Susan D, Kenyon, Elaina M, Schmid, Judith E, George, Barbara Jane, Hughes, Michael F, Sey, Yusupha M, Tennant, Alan, MacMillan, Denise K, Simmons, Jane Ellen, McQueen, Charlene A, Pandiri, Arun, Wood, Charles E, Corton, J Christopher

“…Current strategies for predicting carcinogenic mode of action for nongenotoxic chemicals are based on identification of early key events in toxicity pathways…”
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Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action by Lake, April D, Wood, Charles E, Bhat, Virunya S, Chorley, Brian N, Carswell, Gleta K, Sey, Yusupha M, Kenyon, Elaina M, Padnos, Beth, Moore, Tanya M, Tennant, Alan H, Schmid, Judith E, George, Barbara Jane, Ross, David G, Hughes, Michael F, Corton, J Christopher, Simmons, Jane Ellen, McQueen, Charlene A, Hester, Susan D

“…Current strategies for predicting adverse health outcomes of environmental chemicals are centered on early key events in toxicity pathways. However,…”
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The impact of variation in scaling factors on the estimation of internal dose metrics: a case study using bromodichloromethane (BDCM) by Kenyon, Elaina M., Eklund, Christopher, Lipscomb, John C., Pegram, Rex A.

“…A rate for hepatic metabolism (V max ) determined in vitro must be scaled for in vivo use in a physiologically based pharmacokinetic (PBPK) model. This…”
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Development of a human physiologically based pharmacokinetic (PBPK) model for inorganic arsenic and its mono- and di-methylated metabolites by El-Masri, Hisham A., Kenyon, Elaina M.

“…A physiologically-based pharmacokinetic (PBPK) model was developed to estimate levels of arsenic and its metabolites in human tissues and urine after oral…”
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Identifiability of PBPK models with applications to dimethylarsinic acid exposure by Garcia, Ramon I., Ibrahim, Joseph G., Wambaugh, John F., Kenyon, Elaina M., Setzer, R. Woodrow

“…Any statistical model should be identifiable in order for estimates and tests using it to be meaningful. We consider statistical analysis of…”
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Dose-dependent effects on tissue distribution and metabolism of dimethylarsinic acid in the mouse after intravenous administration by Hughes, Michael F., Del Razo, Luz Maria, Kenyon, Elaina M.

“…Most mammals methylate inorganic arsenic to dimethylarsinic acid (DMA). This organic arsenical causes organ-specific toxicity and is a multi-organ tumor…”
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Interspecies extrapolation by Kenyon, Elaina M

“…Interspecies extrapolation encompasses two related but distinct topic areas that are germane to quantitative extrapolation and hence computational…”
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Neurobehavioral Effects of Acute Exposure to Four Solvents: Meta-analyses by Benignus, Vernon A., Bushnell, Philip J., Boyes, William K., Eklund, Chris, Kenyon, Elaina M.

“…Meta- and reanalyses of the available data for the neurobehavioral effects of acute inhalation exposure to toluene were reported by Benignus et al. The present…”
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A General Physiological and Toxicokinetic (GPAT) Model for Simulating Complex Toluene Exposure Scenarios in Humans by Benignus, Vernon A., Coleman, Thomas, Eklund, Christopher R., Kenyon, Elaina M.

“…Realistic simulation of environmental exposure scenarios requires dynamic methods in which exposures and human activities vary continuously as a function of…”
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A Physiologically based Pharmacokinetic Model for Intravenous and Ingested Dimethylarsinic Acid in Mice by Evans, Marina V., Dowd, Sean M., Kenyon, Elaina M., Hughes, Michael F., El-Masri, Hisham A.

“…A physiologically based pharmacokinetic (PBPK) model for the organoarsenical dimethylarsinic acid (DMAV) was developed in mice. The model was calibrated using…”
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Quantitative Comparisons of the Acute Neurotoxicity of Toluene in Rats and Humans by Benignus, Vernon A., Boyes, William K., Kenyon, Elaina M., Bushnell, Philip J.

“…The behavioral and neurophysiological effects of acute exposure to toluene are the most thoroughly explored of all the hydrocarbon solvents. Behavioral effects…”
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