Search Results - "Kenyon, Cynthia"

The genetics of ageing by Kenyon, Cynthia J

“…The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more. Assuming that the ancestor we share with nematodes…”
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The Plasticity of Aging: Insights from Long-Lived Mutants by Kenyon, Cynthia

“…Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all increase the life spans of model organisms. These…”
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A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage by Bohnert, K. Adam, Kenyon, Cynthia

“…Sperm-activated lysosomes enhance proteostasis in nematode oocytes just before fertilization; this could prevent transmission of damaged proteins to the next…”
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How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude by Podshivalova, Katie, Kerr, Rex A., Kenyon, Cynthia

“…The goal of aging research is to extend healthy, active life. For decades, C. elegans daf-2 insulin/insulin-like growth factor 1 (IGF-1) receptor mutants have…”
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Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression by Lee, Seung-Jae, Murphy, Coleen T., Kenyon, Cynthia

“…Many studies have addressed the effect of dietary glycemic index on obesity and diabetes, but little is known about its effect on life span itself. We found…”
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Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators by Zhang, Peichuan, Judy, Meredith, Lee, Seung-Jae, Kenyon, Cynthia

“…In long-lived C. elegans insulin/IGF-1 pathway mutants, the life-extending FOXO transcription factor DAF-16 is present throughout the animal, but we find that…”
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Regulation of the Longevity Response to Temperature by Thermosensory Neurons in Caenorhabditis elegans by Lee, Seung-Jae, Kenyon, Cynthia

“…Many ectotherms, including C. elegans, have shorter life spans at high temperature than at low temperature. High temperature is generally thought to increase…”
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Individual cell types in C. elegans age differently and activate distinct cell-protective responses by Roux, Antoine Emile, Yuan, Han, Podshivalova, Katie, Hendrickson, David, Kerr, Rex, Kenyon, Cynthia, Kelley, David

“…Aging is characterized by a global decline in physiological function. However, by constructing a complete single-cell gene expression atlas, we find that…”
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Germ-Cell Loss Extends C. elegans Life Span through Regulation of DAF-16 by kri-1 and Lipophilic-Hormone Signaling by Berman, Jennifer R., Kenyon, Cynthia

“…In C. elegans, removing the germ cells extends life span by triggering the nuclear localization and activation of the DAF-16/FOXO transcription factor in the…”
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Widespread protein aggregation as an inherent part of aging in C. elegans by David, Della C, Ollikainen, Noah, Trinidad, Jonathan C, Cary, Michael P, Burlingame, Alma L, Kenyon, Cynthia

“…Aberrant protein aggregation is a hallmark of many age-related diseases, yet little is known about whether proteins aggregate with age in a non-disease…”
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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans by Hansen, Malene, Chandra, Abha, Mitic, Laura L, Onken, Brian, Driscoll, Monica, Kenyon, Cynthia

“…In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR…”
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Sources of Infant Pertussis Infection in the United States by Skoff, Tami H, Kenyon, Cynthia, Cocoros, Noelle, Liko, Juventila, Miller, Lisa, Kudish, Kathy, Baumbach, Joan, Zansky, Shelley, Faulkner, Amanda, Martin, Stacey W

“…Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when…”
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Interventions to Slow Aging in Humans: Are We Ready? by Longo, Valter D., Antebi, Adam, Bartke, Andrzej, Barzilai, Nir, Brown‐Borg, Holly M., Caruso, Calogero, Curiel, Tyler J., Cabo, Rafael, Franceschi, Claudio, Gems, David, Ingram, Donald K., Johnson, Thomas E., Kennedy, Brian K., Kenyon, Cynthia, Klein, Samuel, Kopchick, John J., Lepperdinger, Guenter, Madeo, Frank, Mirisola, Mario G., Mitchell, James R., Passarino, Giuseppe, Rudolph, Karl L., Sedivy, John M., Shadel, Gerald S., Sinclair, David A., Spindler, Stephen R., Suh, Yousin, Vijg, Jan, Vinciguerra, Manlio, Fontana, Luigi

“…Summary The workshop entitled ‘Interventions to Slow Aging in Humans: Are We Ready?’ was held in Erice, Italy, on October 8–13, 2013, to bring together leading…”
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Waning immunity to pertussis following 5 doses of DTaP by Tartof, Sara Y, Lewis, Melissa, Kenyon, Cynthia, White, Karen, Osborn, Andrew, Liko, Juventila, Zell, Elizabeth, Martin, Stacey, Messonnier, Nancy E, Clark, Thomas A, Skoff, Tami H

“…To assess the risk of pertussis by time since vaccination in children in Minnesota and Oregon who received 5 doses of acellular pertussis vaccines (DTaP)…”
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Could a hormone point the way to life extension? by Kenyon, Cynthia

“…Mice that have been genetically modified to produce high levels of fibroblast growth factor-21 live longer than mice with normal levels of this hormone…”
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Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons by Alcedo, Joy, Kenyon, Cynthia

“…The life span of C. elegans is extended by mutations that inhibit the function of sensory neurons. In this study, we show that specific subsets of sensory…”
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Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity by Henis-Korenblit, Sivan, Zhang, Peichuan, Hansen, Malene, McCormick, Mark, Lee, Seung-Jae, Cary, Michael, Kenyon, Cynthia

“…When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response is activated. This ER stress response restores ER…”
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The genetics of ageing by Kenyon, Cynthia J

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Tissue-Specific Activities of C. elegans DAF-16 in the Regulation of Lifespan by Libina, Nataliya, Berman, Jennifer R., Kenyon, Cynthia

“…In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced insulin/IGF-1 signaling or germline ablation. In this study, we have…”
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A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans by Ghazi, Arjumand, Henis-Korenblit, Sivan, Kenyon, Cynthia

“…In Caenorhabditis elegans and Drosophila melanogaster, the aging of the soma is influenced by the germline. When germline-stem cells are removed, aging slows…”
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