Search Results - "Kent, Thomas A"

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective by Derry, Paul J., Hegde, Muralidhar L., Jackson, George R., Kayed, Rakez, Tour, James M., Tsai, Ah-Lim, Kent, Thomas A.

“…•Iron can facilitate oxidative stress and the cell death pathway ferroptosis.•The Alzheimer disease related pathological proteins, amyloid-β and tau, bind iron…”
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Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations by FISHER, Marc, FEUERSTEIN, Giora, HOWELLS, David W, HUM, Patricia D, KENT, Thomas A, SAVITZ, Sean I, LO, Eng H

“…The initial Stroke Therapy Academic Industry Roundtable (STAIR) recommendations published in 1999 were intended to improve the quality of preclinical studies…”
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Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications by Simard, J Marc, Dr, Kent, Thomas A, MD, Chen, Mingkui, MD, Tarasov, Kirill V, PhD, Gerzanich, Volodymyr, MD

“…Summary Focal cerebral ischaemia and post-ischaemic reperfusion cause cerebral capillary dysfunction, resulting in oedema formation and haemorrhagic…”
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Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters by Samuel, Errol L. G., Marcano, Daniela C., Berka, Vladimir, Bitner, Brittany R., Wu, Gang, Potter, Austin, Fabian, Roderic H., Pautler, Robia G., Kent, Thomas A., Tsai, Ah-Lim, Tour, James M.

“…Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an…”
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RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway by Ni, Yong, Gu, Wei-Wei, Liu, Zhi-He, Zhu, Yong-Ming, Rong, Jia-Guo, Kent, Thomas A., Li, Min, Qiao, Shi-Gang, An, Jian-Zhong, Zhang, Hui-Ling

“…[Display omitted] •Inhibition of RIP1K produces neuroprotection against focal cerebral ischemia.•Inhibition of RIP1K directly protects ischemic neurons and…”
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Hyperglycemia in acute ischemic stroke: a vascular perspective by Martini, Sharyl R, Kent, Thomas A

“…Admission hyperglycemia complicates approximately one-third of acute ischemic strokes and is associated with a worse clinical outcome. Both human and animal…”
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Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia–reperfusion brain injury by Zhu, Yong-Ming, Gao, Xue, Ni, Yong, Li, Wei, Kent, Thomas A, Qiao, Shi-Gang, Wang, Chen, Xu, Xiao-Xuan, Zhang, Hui-Ling

“…Graphical abstract…”
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Inhibition of autophagy blocks cathepsins–tBid–mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes by Zhou, Xian-Yong, Luo, Yu, Zhu, Yong-Ming, Liu, Zhi-He, Kent, Thomas A, Rong, Jia-Guo, Li, Wei, Qiao, Shi-Gang, Li, Min, Ni, Yong, Ishidoh, Kazumi, Zhang, Hui-Ling

“…Our previous study and others have demonstrated that autophagy is activated in ischemic astrocytes and contributes to astrocytic cell death. However, the…”
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Mechanistic Study of the Conversion of Superoxide to Oxygen and Hydrogen Peroxide in Carbon Nanoparticles by Jalilov, Almaz S, Zhang, Chenhao, Samuel, Errol L. G, Sikkema, William K. A, Wu, Gang, Berka, Vladimir, Kent, Thomas A, Tsai, Ah-Lim, Tour, James M

“…Hydrophilic carbon clusters (HCCs) are oxidized carbon nanoparticles with a high affinity for electrons. The electron accepting strength of HCCs, employing the…”
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The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis by Derry, Paul J, Vo, Anh Tran Tram, Gnanansekaran, Aswini, Mitra, Joy, Liopo, Anton V, Hegde, Muralidhar L, Tsai, Ah-Lim, Tour, James M, Kent, Thomas A

“…Intracerebral hemorrhage (ICH) is a particularly devastating event both because of the direct injury from space-occupying blood to the sequelae of the brain…”
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Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications by Olson, Kenneth R., Clear, Kasey J., Derry, Paul J., Gao, Yan, Ma, Zhilin, Cieplik, Nathaniel M., Fiume, Alyssa, Gaziano, Dominic J., Kasko, Stephen M., Narloch, Kathleen, Velander, Cecilia L., Nwebube, Ifeyinwa, Pallissery, Collin J., Pfaff, Ella, Villa, Brian P., Kent, Thomas A., Wu, Gang, Straub, Karl D.

“…1,4-Napththoquinones (NQs) are clinically relevant therapeutics that affect cell function through production of reactive oxygen species (ROS) and formation of…”
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Efficacy of Novel Carbon Nanoparticle Antioxidant Therapy in a Severe Model of Reversible Middle Cerebral Artery Stroke in Acutely Hyperglycemic Rats by Fabian, Roderic H, Derry, Paul J, Rea, Harriett Charmaine, Dalmeida, William V, Nilewski, Lizanne G, Sikkema, William K A, Mandava, Pitchaiah, Tsai, Ah-Lim, Mendoza, Kimberly, Berka, Vladimir, Tour, James M, Kent, Thomas A

“…While oxidative stress can be measured during transient cerebral ischemia, antioxidant therapies for ischemic stroke have been clinically unsuccessful. Many…”
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Telemedicine in Prehospital Acute Stroke Care: An Expanding Infrastructure for Treatment and Research by Derry, Paul J, Mandava, Pitchaiah, Kent, Thomas A

“…See Article by Geisler et al…”
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The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase by Olson, Kenneth R, Takata, Tsuyoshi, Clear, Kasey J, Gao, Yan, Ma, Zhilin, Pfaff, Ella, Mouli, Karthik, Kent, Thomas A, Jones, Jr, Prentiss, Fukuto, Jon, Wu, Gang, Straub, Karl D

“…LCS-1, a putative selective inhibitor of SOD1, is a substituted pyridazinone with rudimentary similarity to quinones and naphthoquinones. As quinones…”
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Using Mobile Video-Teleconferencing to Deliver Secondary Stroke Prevention Interventions: A Pilot Study by Anderson, Jane A., Kimmel, Barbara, Sansgiry, Shubhada, Venkatasubba Rao, Chethan P., Ovalle, Anette P., Cerra-Stewart, Colleen A., Kent, Thomas A.

“…Objectives: Patient self-management support (SMS) interventions help stroke survivors control stroke risk factors and assist with secondary prevention. We…”
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Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia by Fabian, Roderic H, Perez-Polo, J Regino, Kent, Thomas A

“…Decreased cerebral blood flow (CBF) has been observed following the resuscitation from neonatal hypoxic-ischemic injury, but its mechanism is not known. We…”
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Quantification of errors in ordinal outcome scales using shannon entropy: effect on sample size calculations by Mandava, Pitchaiah, Krumpelman, Chase S, Shah, Jharna N, White, Donna L, Kent, Thomas A

“…Clinical trial outcomes often involve an ordinal scale of subjective functional assessments but the optimal way to quantify results is not clear. In stroke,…”
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Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke by Alexandrov, Andrei V., Tsivgoulis, Georgios, Köhrmann, Martin, Katsanos, Aristeidis H., Soinne, Lauri, Barreto, Andrew D., Rothlisberger, Travis, Sharma, Vijay K., Mikulik, Robert, Muir, Keith W., Levi, Christopher R., Molina, Carlos A., Saqqur, Maher, Mavridis, Dimitris, Psaltopoulou, Theodora, Vosko, Milan R., Fiebach, Jochen B., Mandava, Pitchaiah, Kent, Thomas A., Alexandrov, Anne W., Schellinger, Peter D.

“…Background: Results of our recently published phase III randomized clinical trial of ultrasound-enhanced thrombolysis (sonothrombolysis) using an…”
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Empathic deficits and alexithymia in trauma-related impulsive aggression by Teten, Andra L., Miller, Lisa A., Bailey, Sara D., Dunn, Nancy Jo, Kent, Thomas A.

“…Our long term interest is to develop a developmental model of impulsive aggression based on a confluence of social, psychological and biological features. This…”
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Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats by Stroemer, R P, Kent, T A, Hulsebosch, C E

“…Neuroanatomical plasticity is well described in lesions of the hippocampus but remains a subject of some controversy in the neocortex. The purpose of the…”
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