Search Results - "Kensler, Robert W."

Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments by Kensler, Robert W., Craig, Roger, Moss, Richard L.

“…Cardiac myosin binding protein C (cMyBP-C) has a key regulatory role in cardiac contraction, but the mechanism by which changes in phosphorylation of cMyBP-C…”
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The Myosin-binding Protein C Motif Binds to F-actin in a Phosphorylation-sensitive Manner by Shaffer, Justin F., Kensler, Robert W., Harris, Samantha P.

“…Cardiac myosin-binding protein C (cMyBP-C) is a regulatory protein expressed in cardiac sarcomeres that is known to interact with myosin, titin, and actin…”
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Atomic model of the human cardiac muscle myosin filament by Al-Khayat, Hind A., Kensler, Robert W., Squire, John M., Marston, Steven B., Morris, Edward P.

“…Of all the myosin filaments in muscle, the most important in terms of human health, and so far the least studied, are those in the human heart. Here we report…”
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Zebrafish Cardiac Muscle Thick Filaments: Isolation Technique and Three-Dimensional Structure by González-Solá, Maryví, AL-Khayat, Hind A., Behra, Martine, Kensler, Robert W.

“…To understand how mutations in thick filament proteins such as cardiac myosin binding protein-C or titin, cause familial hypertrophic cardiomyopathies, it is…”
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Structure and Orientation of Troponin in the Thin Filament by Paul, Danielle M., Morris, Edward P., Kensler, Robert W., Squire, John M.

“…The troponin complex on the thin filament plays a crucial role in the regulation of muscle contraction. However, the precise location of troponin relative to…”
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Three-Dimensional Structure of the M-region (Bare Zone) of Vertebrate Striated Muscle Myosin Filaments by Single-Particle Analysis by AL-Khayat, Hind A., Kensler, Robert W., Morris, Edward P., Squire, John M.

“…The rods of anti-parallel myosin molecules overlap at the centre of bipolar myosin filaments to produce an M-region (bare zone) that is free of myosin heads…”
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Binding of the N-terminal fragment C0–C2 of cardiac MyBP-C to cardiac F-actin by Kensler, Robert W., Shaffer, Justin F., Harris, Samantha P.

“…Cardiac myosin-binding protein C (cMyBP-C), a major accessory protein of cardiac thick filaments, is thought to play a key role in the regulation of myocardial…”
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The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position by Mun, Ji Young, Kensler, Robert W, Harris, Samantha P, Craig, Roger

“…Abstract Mutations in cardiac myosin binding protein C (cMyBP-C), a thick filament protein that modulates contraction of the heart, are a leading cause of…”
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The Structure of Isolated Cardiac Myosin Thick Filaments from Cardiac Myosin Binding Protein-C Knockout Mice by Kensler, Robert W., Harris, Samantha P.

“…Mutations in the thick filament associated protein cardiac myosin binding protein-C (cMyBP-C) are a major cause of familial hypertrophic cardiomyopathy…”
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Myosin filament 3D structure in mammalian cardiac muscle by AL-Khayat, Hind A., Morris, Edward P., Kensler, Robert W., Squire, John M.

“…A number of cardiac myopathies (e.g. familial hypertrophic cardiomyopathy and dilated cardiomyopathy) are linked to mutations in cardiac muscle myosin filament…”
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The mammalian cardiac muscle thick filament: Crossbridge arrangement by Kensler, Robert W.

“…Although skeletal muscle thick filaments have been extensively studied, information on the structure of cardiac thick filaments is limited. Since cardiac…”
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The mammalian cardiac muscle thick filament: Backbone contributions to meridional reflections by Kensler, Robert W.

“…Information about the structure of the vertebrate striated muscle thick filament backbone is important for understanding the arrangement of both the rod…”
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3D structure of relaxed fish muscle myosin filaments by single particle analysis by AL-Khayat, Hind A., Morris, Edward P., Kensler, Robert W., Squire, John M.

“…To understand the structural changes involved in the force-producing myosin cross-bridge cycle in vertebrate muscle it is necessary to know the arrangement and…”
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Mammalian Cardiac Muscle Thick Filaments: Their Periodicity and Interactions with Actin by Kensler, Robert W.

“…Cardiac muscle has been extensively studied, but little information is available on the detailed macromolecular structure of its thick filament. To elucidate…”
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3D Structure of Fish Muscle Myosin Filaments by Eakins, Felicity, AL-Khayat, Hind A., Kensler, Robert W., Morris, Ed P., Squire, John M.

“…Myosinfilaments isolated from goldfish (Carassius auratus) muscle under relaxing conditions and viewed in negative stain by electron microscopy have been…”
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Crossbridge Arrangement in Cardiac Thick Filaments Isolated from cMyBP-C Phosphomimetic Mice by Kensler, Robert W., Craig, Roger, Moss, Richard L.

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Zebrafish Cardiac Muscle Thick Filaments; Isolation without Proteolytic Enzymes by Gonzalez-Sola, Maryvi, Huertas-Toledo, Jaime, Kensler, Robert W.

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The HCM Mutation L348P in cMyBP-C Enhances Thin Filament Activation through Tropomyosin Shift by Mun, Ji Young, Kensler, Robert W., Harris, Samantha P., Craig, Roger

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3D-Reconstruction of the Isolated Zebrafish Cardiac Muscle Thick Filament by Gonzalez, Maryvi, AL-Khayat, Hind A., Behra, Martine L., Kensler, Robert W.

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Mechanical Unfolding of Cardiac Myosin Binding Protein-C by Atomic Force Microscopy by Karsai, Árpád, Kensler, Robert W., Kellermayer, Miklós, Harris, Samantha P.

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