Search Results - "Kenny, B.A."

Characterization of an α1D‐adrenoceptor mediating the contractile response of rat aorta to noradrenaline by Kenny, B.A., Chalmers, D.H., Philpott, P.C., Naylor, A.M.

“…1 The affinities of a number of α1 ‐adrenoceptor antagonists were determined by displacement of [3H]‐prazosin binding from cloned human α1A‐adrenoceptors…”
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Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: binding, functional and in vivo studies by Kenny, B.A., Miller, A.M., Williamson, I.J.R., O'Connell, J., Chalmers, D.H., Naylor, A.M.

“…1 The profile of a range of α1 adrenoceptor antagonists was determined in vitro against cloned human α1A, α1B and α1D adrenoceptors and against…”
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Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies by Kenny, B A, Miller, A M, Williamson, I J, O'Connell, J, Chalmers, D H, Naylor, A M

“…1. The profile of a range of alpha 1 adrenoceptor antagonists was determined in vitro against cloned human alpha 1A, alpha 1B and alpha 1D adrenoceptors and…”
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Characterization of an α 1D ‐adrenoceptor mediating the contractile response of rat aorta to noradrenaline by Kenny, B.A., Chalmers, D.H., Philpott, P.C., Naylor, A.M.

“…The affinities of a number of α 1 ‐adrenoceptor antagonists were determined by displacement of [ 3 H]‐prazosin binding from cloned human α 1A ‐adrenoceptors…”
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Pharmacological properties of the cloned α1A/D‐adrenoceptor subtype are consistent with the α1A‐adrenoceptor characterized in rat cerebral cortex and vas deferens by Kenny, B.A., Naylor, A.M., Greengrass, P.M., Russell, M.J., Friend, S.J., Read, A.M., Wyllie, M.G.

“…1 The pharmacological characteristics of cloned mammalian α1A/D‐, α1B‐ and α1C‐adrenoceptor subtypes expressed in rat 1 fibroblasts were determined in…”
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Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia by Brown, C.M., Calder, C., Linton, C., Small, C., Kenny, B.A., Spedding, M., Patmore, L.

“…1 Changes in the peripheral type benzodiazepine binding site density following middle cerebral artery occlusion in the mouse, have been used as a marker of…”
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[3H]‐RS‐15385–197, a selective and high affinity radioligand for α2‐adrenoceptors: implications for receptor classification by MacKinnon, A.C., Kilpatrick, A.T., Kenny, B.A., Speeding, M., Brown, C.M.

“…1 RS‐15385–197 is the most potent and selective α2‐adrenoceptor antagonist available. We have used [3H]‐RS‐15385–197 to define α2‐adrenoceptor subtypes. The…”
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Pharmacological properties of the cloned α 1A/D ‐adrenoceptor subtype are consistent with the α 1A ‐adrenoceptor characterized in rat cerebral cortex and vas deferens by Kenny, B.A., Naylor, A.M., Greengrass, P.M., Russell, M.J., Friend, S.J., Read, A.M., Wyllie, M.G.

“…The pharmacological characteristics of cloned mammalian α 1A/D ‐, α 1B ‐ and α 1C ‐adrenoceptor subtypes expressed in rat 1 fibroblasts were determined in…”
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[3H]-RS-15385-197, a selective and high affinity radioligand for alpha 2-adrenoceptors: implications for receptor classification by MacKinnon, A C, Kilpatrick, A T, Kenny, B A, Spedding, M, Brown, C M

“…1. RS-15385-197 is the most potent and selective alpha 2-adrenoceptor antagonist available. We have used [3H]-RS-15385-197 to define alpha 2-adrenoceptor…”
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Muscarinic activity of McN‐A‐343 and its value in muscarinic receptor classification by Eglen, R.M., Kenny, B.A., Michel, A.D., Whiting, R.L.

“…1 The affinity and potency of McN‐A‐343 (4‐(m‐chlorophenyl‐carbamoyloxy) −2‐butynyltrimethylammonium chloride) has been assessed at a range of M1 and M2…”
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Changes in [3H]‐PK 11195 and [3H]‐8‐OH‐DPAT binding following forebrain ischaemia in the gerbil by Kenny, B.A., MacKinnon, A.C., Spedding, Michael, Brown, Christine M.

“…1 A high density of [3H]‐PK 11195 binding sites was present in gerbil cortical membranes (Bmax [3H]‐PK 11195 1360 ± 71 fmol mg−1 protein) in comparison to rat…”
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