Search Results - "Kenney, Grace E"

Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase by Ro, Soo Y., Schachner, Luis F., Koo, Christopher W., Purohit, Rahul, Remis, Jonathan P., Kenney, Grace E., Liauw, Brandon W., Thomas, Paul M., Patrie, Steven M., Kelleher, Neil L., Rosenzweig, Amy C.

“…Aerobic methane oxidation is catalyzed by particulate methane monooxygenase (pMMO), a copper-dependent, membrane metalloenzyme composed of subunits PmoA, PmoB,…”
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The biosynthesis of methanobactin by Kenney, Grace E, Dassama, Laura M K, Pandelia, Maria-Eirini, Gizzi, Anthony S, Martinie, Ryan J, Gao, Peng, DeHart, Caroline J, Schachner, Luis F, Skinner, Owen S, Ro, Soo Y, Zhu, Xiao, Sadek, Monica, Thomas, Paul M, Almo, Steven C, Bollinger, Jr, J Martin, Krebs, Carsten, Kelleher, Neil L, Rosenzweig, Amy C

“…Metal homeostasis poses a major challenge to microbes, which must acquire scarce elements for core metabolic processes. Methanobactin, an extensively modified…”
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A Peroxodiiron(III/III) Intermediate Mediating Both N‑Hydroxylation Steps in Biosynthesis of the N‑Nitrosourea Pharmacophore of Streptozotocin by the Multi-domain Metalloenzyme SznF by McBride, Molly J, Sil, Debangsu, Ng, Tai L, Crooke, Anne Marie, Kenney, Grace E, Tysoe, Christina R, Zhang, Bo, Balskus, Emily P, Boal, Amie K, Krebs, Carsten, Bollinger, J. Martin

“…The alkylating warhead of the pancreatic cancer drug strepto­zotocin (SZN) contains an N-nitroso­urea moiety constructed from N ω-methyl-l-arginine (l-NMA) by…”
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Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria by Fisher, Oriana S., Kenney, Grace E., Ross, Matthew O., Ro, Soo Y., Lemma, Betelehem E., Batelu, Sharon, Thomas, Paul M., Sosnowski, Victoria C., DeHart, Caroline J., Kelleher, Neil L., Stemmler, Timothy L., Hoffman, Brian M., Rosenzweig, Amy C.

“…Methane-oxidizing microbes catalyze the oxidation of the greenhouse gas methane using the copper-dependent enzyme particulate methane monooxygenase (pMMO)…”
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Copper-responsive gene expression in the methanotroph Methylosinus trichosporium OB3b by Kenney, Grace E, Sadek, Monica, Rosenzweig, Amy C

“…Methanotrophic bacteria convert methane to methanol using methane monooxygenase (MMO) enzymes. In many strains, either an iron-containing soluble (sMMO) or a…”
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Chemistry and Biology of the Copper Chelator Methanobactin by Kenney, Grace E, Rosenzweig, Amy C

“…Methanotrophic bacteria, organisms that oxidize methane, produce a small copper chelating molecule called methanobactin (Mb). Mb binds Cu(I) with high affinity…”
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Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins by Park, Yun Ji, Kenney, Grace E, Schachner, Luis F, Kelleher, Neil L, Rosenzweig, Amy C

“…Methanobactins (Mbns) are ribosomally produced, post-translationally modified bacterial natural products with a high affinity for copper. MbnN, a pyridoxal…”
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Chalkophores by Kenney, Grace E, Rosenzweig, Amy C

“…Copper-binding metallophores, or chalkophores, play a role in microbial copper homeostasis that is analogous to that of siderophores in iron homeostasis. The…”
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Methanobactins: Maintaining copper homeostasis in methanotrophs and beyond by Kenney, Grace E., Rosenzweig, Amy C.

“…Methanobactins (Mbns) are ribosomally produced, post-translationally modified natural products that bind copper with high affinity and specificity. Originally…”
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The CopC Family: Structural and Bioinformatic Insights into a Diverse Group of Periplasmic Copper Binding Proteins by Lawton, Thomas J, Kenney, Grace E, Hurley, Joseph D, Rosenzweig, Amy C

“…The CopC proteins are periplasmic copper binding proteins believed to play a role in bacterial copper homeostasis. Previous studies have focused on CopCs that…”
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Structure and function of prodrug-activating peptidases by Velilla, José A., Kenney, Grace E., Gaudet, Rachelle

“…Bacteria protect themselves from the toxicity of antimicrobial metabolites they produce through several strategies. In one resistance mechanism, bacteria…”
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Structural basis of colibactin activation by the ClbP peptidase by Velilla, José A., Volpe, Matthew R., Kenney, Grace E., Walsh, Richard M., Balskus, Emily P., Gaudet, Rachelle

“…Colibactin, a DNA cross-linking agent produced by gut bacteria, is implicated in colorectal cancer. Its biosynthesis uses a prodrug resistance mechanism: a…”
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Dual Pathways for Copper Uptake by Methanotrophic Bacteria by Balasubramanian, Ramakrishnan, Kenney, Grace E., Rosenzweig, Amy C.

“…Methanobactin (Mb), a 1217-Da copper chelator produced by the methanotroph Methylosinus trichosporium OB3b, is hypothesized to mediate copper acquisition from…”
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Methanobactin transport machinery by Dassama, Laura M. K., Kenney, Grace E., Ro, Soo Y., Zielazinski, Eliza L., Rosenzweig, Amy C.

“…Methanotrophic bacteria use methane, a potent greenhouse gas, as their primary source of carbon and energy. The first step in methane metabolism is its…”
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Characterization of a Copper-Chelating Natural Product from the Methanotroph Methylosinus sp. LW3 by Park, Yun Ji, Roberts, Gerri M, Montaser, Rana, Kenney, Grace E, Thomas, Paul M, Kelleher, Neil L, Rosenzweig, Amy C

“…Methanobactins (Mbns) are ribosomally produced, post-translationally modified peptidic natural products that bind copper with high affinity. Methanotrophic…”
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Genome mining for methanobactins by Kenney, Grace E, Rosenzweig, Amy C

“…Methanobactins (Mbns) are a family of copper-binding natural products involved in copper uptake by methanotrophic bacteria. The few Mbns that have been…”
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A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria by Bisanz, Jordan E., Soto-Perez, Paola, Noecker, Cecilia, Aksenov, Alexander A., Lam, Kathy N., Kenney, Grace E., Bess, Elizabeth N., Haiser, Henry J., Kyaw, Than S., Yu, Feiqiao B., Rekdal, Vayu M., Ha, Connie W.Y., Devkota, Suzanne, Balskus, Emily P., Dorrestein, Pieter C., Allen-Vercoe, Emma, Turnbaugh, Peter J.

“…Despite the remarkable microbial diversity found within humans, our ability to link genes to phenotypes is based upon a handful of model microorganisms. We…”
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Methanobactins: from genome to function by Dassama, Laura M K, Kenney, Grace E, Rosenzweig, Amy C

“…Methanobactins (Mbns) are ribosomally produced, post-translationally modified peptide (RiPP) natural products that bind copper with high affinity using…”
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Revving an Engine of Human Metabolism: Activity Enhancement of Triosephosphate Isomerase via Hemi-Phosphorylation by Schachner, Luis F., Soye, Benjamin Des, Ro, Soo, Kenney, Grace E., Ives, Ashley N., Su, Taojunfeng, Goo, Young Ah, Jewett, Michael C., Rosenzweig, Amy C., Kelleher, Neil L.

“…Triosephosphate isomerase (TPI) performs the 5th step in glycolysis, operates near the limit of diffusion, and is involved in “moonlighting” functions. Its…”
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Characterization of Methanobactin from Methylosinus sp. LW4 by Kenney, Grace E, Goering, Anthony W, Ross, Matthew O, DeHart, Caroline J, Thomas, Paul M, Hoffman, Brian M, Kelleher, Neil L, Rosenzweig, Amy C

“…Methanobactins (Mbns) are a growing family of ribosomally produced, post-translationally modified natural products. Characteristic nitrogen-containing…”
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