Search Results - "Kenneth R Shroyer"

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference by Premsrirut, Prem K., Dow, Lukas E., Kim, Sang Yong, Camiolo, Matthew, Malone, Colin D., Miething, Cornelius, Scuoppo, Claudio, Zuber, Johannes, Dickins, Ross A., Kogan, Scott C., Shroyer, Kenneth R., Sordella, Raffaella, Hannon, Gregory J., Lowe, Scott W.

“…RNA interference is a powerful tool for studying gene function, however, the reproducible generation of RNAi transgenic mice remains a significant limitation…”
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miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14 by Li, Yiyi, Kuscu, Cem, Banach, Anna, Zhang, Qian, Pulkoski-Gross, Ashleigh, Kim, Deborah, Liu, Jingxuan, Roth, Eric, Li, Ellen, Shroyer, Kenneth R, Denoya, Paula I, Zhu, Xiaoxia, Chen, Longhua, Cao, Jian

“…Upregulation of matrix metalloproteinase MMP-14 (MT1-MMP) is associated with poor prognosis in cancer patients, but it is unclear how MMP-14 becomes elevated…”
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PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth by Montal, Emily D., Dewi, Ruby, Bhalla, Kavita, Ou, Lihui, Hwang, Bor Jang, Ropell, Ashley E., Gordon, Chris, Liu, Wan-Ju, DeBerardinis, Ralph J., Sudderth, Jessica, Twaddel, William, Boros, Laszlo G., Shroyer, Kenneth R., Duraisamy, Sekhar, Drapkin, Ronny, Powers, R. Scott, Rohde, Jason M., Boxer, Matthew B., Wong, Kwok-Kin, Girnun, Geoffrey D.

“…Phosphoenolpyruvate carboxykinase (PEPCK) is well known for its role in gluconeogenesis. However, PEPCK is also a key regulator of TCA cycle flux. The TCA…”
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Prognostic significance of miR-205 in endometrial cancer by Karaayvaz, Mihriban, Zhang, Cecilia, Liang, Sharon, Shroyer, Kenneth R, Ju, Jingfang

“…microRNAs have emerged as key regulators of gene expression, and their altered expression has been associated with tumorigenesis and tumor progression. Thus,…”
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Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations by Kanakia, Shruti, Toussaint, Jimmy D, Mullick Chowdhury, Sayan, Tembulkar, Tanuf, Lee, Stephen, Jiang, Ya-Ping, Lin, Richard Z, Shroyer, Kenneth R, Moore, William, Sitharaman, Balaji

“…Abstract Graphene nanoparticle dispersions show immense potential as multifunctional agents for in vivo biomedical applications. Herein, we follow regulatory…”
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Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders by Gaudino, Stephen J., Singh, Ankita, Huang, Huakang, Padiadpu, Jyothi, Jean-Pierre, Makheni, Kempen, Cody, Bahadur, Tej, Shiomitsu, Kiyoshi, Blumberg, Richard, Shroyer, Kenneth R., Beyaz, Semir, Shulzhenko, Natalia, Morgun, Andrey, Kumar, Pawan

“…IL-22 is critical for ameliorating obesity-induced metabolic disorders. However, it is unknown where IL-22 acts to mediate these outcomes. Here we examine the…”
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Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet by Luo, Yongde, Yang, Yaying, Liu, Muyun, Wang, Dan, Wang, Feng, Bi, Yawei, Ji, Juntao, Li, Suyun, Liu, Yan, Chen, Rong, Huang, Haojie, Wang, Xiaojie, Swidnicka-Siergiejko, Agnieszka K., Janowitz, Tobias, Beyaz, Semir, Wang, Guoqiang, Xu, Sulan, Bialkowska, Agnieszka B., Luo, Catherine K., Pin, Christoph L., Liang, Guang, Lu, Xiongbin, Wu, Maoxin, Shroyer, Kenneth R., Wolff, Robert A., Plunkett, William, Ji, Baoan, Li, Zhaoshen, Li, Ellen, Li, Xiaokun, Yang, Vincent W., Logsdon, Craig D., Abbruzzese, James L., Lu, Weiqin

“…Obesity is a risk factor for pancreatic cancer. In mice, a high-fat diet (HFD) and expression of oncogenic KRAS lead to development of invasive pancreatic…”
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Development of Patient-Derived Gastric Cancer Organoids from Endoscopic Biopsies and Surgical Tissues by Gao, Mei, Lin, Miranda, Rao, Manisha, Thompson, Hannah, Hirai, Kelsi, Choi, Minsig, Georgakis, Georgios V., Sasson, Aaron R., Bucobo, Juan Carlos, Tzimas, Demetri, D’Souza, Lionel S., Buscaglia, Jonathan M., Davis, James, Shroyer, Kenneth R., Li, Jinyu, Powers, Scott, Kim, Joseph

“…Background Organoids are three-dimensional in vitro models of human disease developed from benign and malignant gastrointestinal tissues with tremendous…”
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Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility by Escobar-Hoyos, Luisa F, Shah, Ruchi, Roa-Peña, Lucia, Vanner, Elizabeth A, Najafian, Nilofar, Banach, Anna, Nielsen, Erik, Al-Khalil, Ramsey, Akalin, Ali, Talmage, David, Shroyer, Kenneth R

“…Keratins that are overexpressed selectively in human carcinomas may offer diagnostic and prognostic utility. In this study, we show that high expression of…”
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Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker by Escobar-Hoyos, Luisa F, Yang, Jie, Zhu, Jiawen, Cavallo, Julie-Ann, Zhai, Haiyan, Burke, Stephanie, Koller, Antonius, Chen, Emily I, Shroyer, Kenneth R

“…Most previously described immunohistochemical markers of cervical high-grade squamous intraepithelial lesion (HSIL) and squamous cell carcinoma may help to…”
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Annexin A2 promotes glioma cell invasion and tumor progression by Zhai, Haiyan, Acharya, Suchitra, Gravanis, Iordanis, Mehmood, Saira, Seidman, Roberta J, Shroyer, Kenneth R, Hajjar, Katherine A, Tsirka, Stella E

“…Gliomas are highly invasive, lethal brain tumors. Tumor-associated proteases play an important role in glioma progression. Annexin A2 is overexpressed in many…”
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Deep learning-based image analysis methods for brightfield-acquired multiplex immunohistochemistry images by Fassler, Danielle J, Abousamra, Shahira, Gupta, Rajarsi, Chen, Chao, Zhao, Maozheng, Paredes, David, Batool, Syeda Areeha, Knudsen, Beatrice S, Escobar-Hoyos, Luisa, Shroyer, Kenneth R, Samaras, Dimitris, Kurc, Tahsin, Saltz, Joel

“…Multiplex immunohistochemistry (mIHC) permits the labeling of six or more distinct cell types within a single histologic tissue section. The classification of…”
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Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma by Pagnotti, Gabriel M., Chan, M. Ete, Adler, Benjamin J., Shroyer, Kenneth R., Rubin, Janet, Bain, Steven D., Rubin, Clinton T.

“…Myeloma facilitates destruction of bone and marrow. Since physical activity encourages musculoskeletal preservation we evaluated whether low-intensity…”
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Keratin 17 is overexpressed and predicts poor survival in estrogen receptor–negative/human epidermal growth factor receptor-2–negative breast cancer by Merkin, Ross D., Vanner, Elizabeth A., Romeiser, Jamie L., Shroyer, A. Laurie W., Escobar-Hoyos, Luisa F., Li, Jinyu, Powers, Robert S., Burke, Stephanie, Shroyer, Kenneth R.

“…Clinicopathological features of breast cancer have limited accuracy to predict survival. By immunohistochemistry (IHC), keratin 17 (K17) expression has been…”
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Dry heat sterilization as a method to recycle N95 respirator masks: The importance of fit by Yuen, John G, Marshilok, Amy C, Benziger, Peter Todd, Yan, Shan, Cello, Jeronimo, Stackhouse, Chavis A, Kisslinger, Kim, Bock, David C, Takeuchi, Esther S, Takeuchi, Kenneth J, Wang, Lei, Babu, Sruthi, Itzkowitz, Glen, Thanassi, David, Knopf, Daniel A, Shroyer, Kenneth R

“…In times of crisis, including the current COVID-19 pandemic, the supply chain of filtering facepiece respirators, such as N95 respirators, are disrupted. To…”
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Keratin 17 modulates the immune topography of pancreatic cancer by Delgado-Coka, Lyanne, Horowitz, Michael, Torrente-Goncalves, Mariana, Roa-Peña, Lucia, Leiton, Cindy V, Hasan, Mahmudul, Babu, Sruthi, Fassler, Danielle, Oentoro, Jaymie, Bai, Ji-Dong K, Petricoin, 3rd, Emanuel F, Matrisian, Lynn M, Blais, Edik Matthew, Marchenko, Natalia, Allard, Felicia D, Jiang, Wei, Larson, Brent, Hendifar, Andrew, Chen, Chao, Abousamra, Shahira, Samaras, Dimitris, Kurc, Tahsin, Saltz, Joel, Escobar-Hoyos, Luisa F, Shroyer, Kenneth R

“…The immune microenvironment impacts tumor growth, invasion, metastasis, and patient survival and may provide opportunities for therapeutic intervention in…”
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Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP) by Evensen, Nikki A, Li, Yiyi, Kuscu, Cem, Liu, Jingxuan, Cathcart, Jillian, Banach, Anna, Zhang, Qian, Li, Ellen, Joshi, Sonia, Yang, Jie, Denoya, Paula I, Pastorekova, Silvia, Zucker, Stanley, Shroyer, Kenneth R, Cao, Jian

“…Hypoxic stress drives cancer progression by causing a transcriptional reprogramming. Recently, KIAA1199 was discovered to be a cell-migration inducing protein…”
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Differential expression of miRNAs in colon cancer between African and Caucasian Americans: Implications for cancer racial health disparities by LI, ELLEN, JI, PING, OUYANG, NENGTAI, ZHANG, YUANHAO, WANG, XIN YU, RUBIN, DEBORAH C, DAVIDSON, NICHOLAS O, BERGAMASCHI, ROBERTO, SHROYER, KENNETH R, BURKE, STEPHANIE, ZHU, WEI, WILLIAMS, JENNIE L

“…Colorectal cancer (CRC) incidence and mortality are higher in African Americans (AAs) than in Caucasian Americans (CAs) and microRNAs (miRNAs) have been found…”
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O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation by Du, Jianguang, Takeuchi, Hideyuki, Leonhard-Melief, Christina, Shroyer, Kenneth R., Dlugosz, Malgosia, Haltiwanger, Robert S., Holdener, Bernadette C.

“…Thrombospondin type 1 repeat (TSR) superfamily members regulate diverse biological activities ranging from cell motility to inhibition of angiogenesis. In this…”
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RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis by Choi, Yeon Ja, Laclef, Christine, Yang, Ning, Andreu-Cervera, Abraham, Lewis, Joshua, Mao, Xuming, Li, Li, Snedecor, Elizabeth R, Takemaru, Ken-Ichi, Qin, Chuan, Schneider-Maunoury, Sylvie, Shroyer, Kenneth R, Hannun, Yusuf A, Koch, Peter J, Clark, Richard A, Payne, Aimee S, Kowalczyk, Andrew P, Chen, Jiang

“…Cilia-related proteins are believed to be involved in a broad range of cellular processes. Retinitis pigmentosa GTPase regulator interacting protein 1-like…”
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