Search Results - "Kenneth Cowan"

Correction: ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation by Kolb, Ryan H, Greer, Patrick M, Cao, Phu T, Cowan, Kenneth H, Yan, Ying

“…For the Fig 6A ETOP ATR activity panel, 6B ATR activity panel, and 6C DOX Chk2 activity panel, only the cropped images are available; however, the authors’…”
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Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers by Li, You, Wang, Xiaosheng, Vural, Suleyman, Mishra, Nitish K, Cowan, Kenneth H, Guda, Chittibabu

“…Breast cancers exhibit highly heterogeneous molecular profiles. Although gene expression profiles have been used to predict the risks and prognostic outcomes…”
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Breast Cancer Collaborative Registry informs understanding of factors predicting sleep quality by Berger, Ann M., Kupzyk, Kevin A., Djalilova, Dilorom M., Cowan, Kenneth H.

“…Significance Poor sleep quality is a common and persistent problem reported by women with breast cancer (BC). Empirical evidence identifies many risk factors…”
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ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation by Kolb, Ryan H, Greer, Patrick M, Cao, Phu T, Cowan, Kenneth H, Yan, Ying

“…Topo II poisons, which target topoisomerase II (topo II) to generate enzyme mediated DNA damage, have been commonly used for anti-cancer treatment. While…”
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Receptor for hyaluronan‐mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients by Tarullo, Sarah E, He, Yuyu, Daughters, Claire, Knutson, Todd P, Henzler, Christine M, Price, Matthew A, Shanley, Ryan, Witschen, Patrice, Tolg, Cornelia, Kaspar, Rachael E, Hallstrom, Caroline, Gittsovich, Lyubov, Sulciner, Megan L, Zhang, Xihong, Forster, Colleen L, Lange, Carol A, Shats, Oleg, Desler, Michelle, Cowan, Kenneth H, Yee, Douglas, Schwertfeger, Kathryn L, Turley, Eva A, McCarthy, James B, Nelson, Andrew C

“…Breast cancer invasion and metastasis result from a complex interplay between tumor cells and the tumor microenvironment (TME). Key oncogenic changes in the…”
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Withdrawal: BRCA1-induced apoptosis involves inactivation of ERK1/2 activities by Yan, Ying, Haas, John P., Kim, Min, Sgagias, Magdalene K., Cowan, Kenneth H.

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Correction: KSR1 is required for cell cycle reinitiation following DNA damage by Razidlo, Gina L., Johnson, Heidi J., Stoeger, Scott M., Cowan, Kenneth H., Bessho, Tadayoshi, Lewis, Robert E.

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The mutational landscape of a US Midwestern breast cancer cohort reveals subtype-specific cancer drivers and prognostic markers by Vellichirammal, Neetha Nanoth, Tan, Yuan-De, Xiao, Peng, Eudy, James, Shats, Oleg, Kelly, David, Desler, Michelle, Cowan, Kenneth, Guda, Chittibabu

“…Female breast cancer remains the second leading cause of cancer-related death in the USA. The heterogeneity in the tumor morphology across the cohort and…”
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Association ofSOD3 promoter DNA methylation with its down-regulation in breast carcinomas by Griess, Brandon, Klinkebiel, David, Kueh, Alice, Desler, Michelle, Cowan, Kenneth, Fitzgerald, Matthew, Teoh-Fitzgerald, Melissa

“…Superoxide dismutase 3 (SOD3) is a secreted antioxidant enzyme that regulates reactive oxygen species in the microenvironment. It is also a potential tumour…”
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Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer by Wen, Hongxiu, Kim, Yeong C, Snyder, Carrie, Xiao, Fengxia, Fleissner, Elizabeth A, Becirovic, Dina, Luo, Jiangtao, Downs, Bradley, Sherman, Simon, Cowan, Kenneth H, Lynch, Henry T, Wang, San Ming

“…Genetic predisposition is the primary risk factor for familial breast cancer. For the majority of familial breast cancer, however, the genetic predispositions…”
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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage by Brody, Lawrence C, Yarden, Ronit I, Pardo-Reoyo, Sherly, Sgagias, Magda, Cowan, Kenneth H

“…The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain-a motif that is found in many proteins that are implicated in DNA damage…”
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The Multidrug Resistance Transporter ABCG2 (Breast Cancer Resistance Protein 1) Effluxes Hoechst 33342 and Is Overexpressed in Hematopoietic Stem Cells by KIM, Min, TURNQUIST, Heth, JACKSON, John, SGAGIAS, Magda, YING YAN, GONG, Maokai, DEAN, Michael, SHARP, John G, COWAN, Kenneth

“…The human ATP-binding cassette superfamily G (White) member 2 ( ABCG2 ) gene and its murine homologue breast cancer resistance protein 1 ( Bcrp1 ) are recently…”
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Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation by Yan, Ying, Hein, Ashley L, Etekpo, Asserewou, Burchett, Katrina M, Lin, Chi, Enke, Charles A, Batra, Surinder K, Cowan, Kenneth H, Ouellette, Michel M

“…[This corrects the article DOI: 10.18632/oncotarget.2500.]…”
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Breast Cancer Risk Reduction, Version 2.2015 by Bevers, Therese B, Ward, John H, Arun, Banu K, Colditz, Graham A, Cowan, Kenneth H, Daly, Mary B, Garber, Judy E, Gemignani, Mary L, Gradishar, William J, Jordan, Judith A, Korde, Larissa A, Kounalakis, Nicole, Krontiras, Helen, Kumar, Shicha, Kurian, Allison, Laronga, Christine, Layman, Rachel M, Loftus, Loretta S, Mahoney, Martin C, Merajver, Sofia D, Meszoely, Ingrid M, Mortimer, Joanne, Newman, Lisa, Pritchard, Elizabeth, Pruthi, Sandhya, Seewaldt, Victoria, Specht, Michelle C, Visvanathan, Kala, Wallace, Anne, Bergman, Mary Ann, Kumar, Rashmi

“…Breast cancer is the most frequently diagnosed malignancy in women in the United States and is second only to lung cancer as a cause of cancer death. To assist…”
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Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation by Yan, Ying, Hein, Ashley L, Etekpo, Asserewou, Burchett, Katrina M, Lin, Chi, Enke, Charles A, Batra, Surinder K, Cowan, Kenneth H, Ouellette, Michel M

“…Radiation therapy is a staple treatment for pancreatic cancer. However, owing to the intrinsic radioresistance of pancreatic cancer cells, radiation therapy…”
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Genome instability in blood cells of a BRCA1+ breast cancer family by Xiao, Fengxia, Kim, Yeong C, Snyder, Carrie, Wen, Hongxiu, Chen, Pei Xian, Luo, Jiangtao, Becirovic, Dina, Downs, Bradley, Cowan, Kenneth H, Lynch, Henry, Wang, San Ming

“…BRCA1 plays an essential role in maintaining genome stability. Inherited BRCA1 germline mutation (BRCA1+) is a determined genetic predisposition leading to…”
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Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells by Yaar, Mina, Eller, Mark S, Panova, Izabela, Kubera, John, Wee, Lee Hng, Cowan, Kenneth H, Gilchrest, Barbara A

“…Cancer is a leading cause of death in Americans. We have identified an inducible cancer avoidance mechanism in cells that reduces mutation rate, reduces and…”
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Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival by ZHENGTANG CHEN, VARNEY, Michelle L, BACKORA, Matthew W, COWAN, Kenneth, SOLHEIM, Joyce C, TALMADGE, James E, SINGH, Rakesh K

“…Tumor production of vascular endothelial cell growth factor (VEGF)-C is associated with tumor lymphangiogenesis and lymph node metastasis. In this study, we…”
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Distinct Neoadjuvant Chemotherapy Response and 5-Year Outcome in Patients With Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Tumors That Reclassify as Basal-Type by the 80-Gene Signature by Whitworth, Pat W, Beitsch, Peter D, Pellicane, James V, Baron, Paul L, Lee, Laura A, Dul, Carrie L, Murray, Mary K, Gittleman, Mark A, Budway, Raye J, Rahman, Rakhshanda Layeequr, Kelemen, Pond R, Dooley, William C, Rock, David T, Cowan, Kenneth H, Lesnikoski, Beth-Ann, Barone, Julie L, Ashikari, Andrew Y, Dupree, Beth B, Wang, Shiyu, Menicucci, Andrea R, Yoder, Erin B, Finn, Christine, Corcoran, Kate, Blumencranz, Lisa E, Audeh, William

“…The 80-gene molecular subtyping signature (80-GS) reclassifies a proportion of immunohistochemistry (IHC)-defined luminal breast cancers (estrogen…”
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Genetic Variants in Circadian Rhythm Genes and Self-Reported Sleep Quality in Women with Breast Cancer by LeVan, Tricia D, Xiao, Peng, Kumar, Gaurav, Kupzyk, Kevin, Qiu, Fang, Klinkebiel, David, Eudy, James, Cowan, Kenneth, Berger, Ann M

“…Women diagnosed with breast cancer (BC) are at increased risk of sleep deficiency. Approximately 30-60% of these women report poor sleep during and following…”
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