Search Results - "Kennerdell, Jason R"

MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging by Kennerdell, Jason R., Liu, Nan, Bonini, Nancy M.

“…Aging is a prominent risk factor for neurodegenerative disease. Defining gene expression mechanisms affecting healthy brain aging should lead to insight into…”
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A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry by Chen, Yanwen, Lear, Travis B., Evankovich, John W., Larsen, Mads B., Lin, Bo, Alfaras, Irene, Kennerdell, Jason R., Salminen, Laura, Camarco, Daniel P., Lockwood, Karina C., Tuncer, Ferhan, Liu, Jie, Myerburg, Michael M., McDyer, John F., Liu, Yuan, Finkel, Toren, Chen, Bill B.

“…SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for the global pandemic of COVID-19 disease. The Spike (S) protein of SARS-CoV-2 attaches to…”
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Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity by Chung, Chia-Yu, Berson, Amit, Kennerdell, Jason R., Sartoris, Ashley, Unger, Travis, Porta, Sílvia, Kim, Hyung-Jun, Smith, Edwin R., Shilatifard, Ali, Van Deerlin, Vivianna, Lee, Virginia M.-Y., Chen-Plotkin, Alice, Bonini, Nancy M.

“…TDP-43 is the major disease protein associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions…”
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Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans by Kennerdell, Jason R, Fetter, Richard D, Bargmann, Cornelia I

“…Wnt signaling through Frizzled proteins guides posterior cells and axons in C. elegans into different spatial domains. Here we demonstrate an essential role…”
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A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis by Chen, Yanwen, Evankovich, John W., Lear, Travis B., Tuncer, Ferhan, Kennerdell, Jason R., Camarco, Daniel P., Shishido, Morgan S., Liu, Yuan, Chen, Bill B.

“…NRF2 is a master regulator of cellular anti-oxidant and anti-inflammatory responses, and strategies to augment NRF2-dependent responses may beneficial in many…”
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Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity by Chung, Chia-Yu, Berson, Amit, Kennerdell, Jason R., Sartoris, Ashley, Unger, Travis, Porta, Sílvia, Kim, Hyung-Jun, Smith, Edwin R., Shilatifard, Ali, Van Deerlin, Vivianna, Lee, Virginia M. -Y., Chen-Plotkin, Alice, Bonini, Nancy M.

“…The original version of this Article contained an error in the author affiliations. The affiliation of Alice Chen-Plotkin with the Department of Neurology,…”
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RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E by Kennerdell, Jason R, Yamaguchi, Shinji, Carthew, Richard W

“…Gene silencing by double-stranded RNA is a widespread phenomenon called RNAi, involving homology-dependent degradation of mRNAs. Here we show that RNAi is…”
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The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila by Liu, Nan, Landreh, Michael, Cao, Kajia, Abe, Masashi, Hendriks, Gert-Jan, Kennerdell, Jason R., Zhu, Yongqing, Wang, Li-San, Bonini, Nancy M.

“…The conserved microRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila , providing a molecular link between ageing and…”
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A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance by Liu, Yuan, Jurczak, Michael J., Lear, Travis B., Lin, Bo, Larsen, Mads B., Kennerdell, Jason R., Chen, Yanwen, Huckestein, Brydie R., Nguyen, Matthew K., Tuncer, Ferhan, Jiang, Yu, Monga, Satdarshan P., O’Donnell, Christopher P., Finkel, Toren, Chen, Bill B., Mallampalli, Rama K.

“…The adenosine monophosphate (AMP)-activated protein kinase (Ampk) is a central regulator of metabolic pathways, and increasing Ampk activity has been…”
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Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis by Lear, Travis B., Lockwood, Karina C., Larsen, Mads, Tuncer, Ferhan, Kennerdell, Jason R., Morse, Christina, Valenzi, Eleanor, Tabib, Tracy, Jurczak, Michael J., Kass, Daniel J., Evankovich, John W., Finkel, Toren, Lafyatis, Robert, Liu, Yuan, Chen, Bill B.

“…Systemic scleroderma (SSc) is an autoimmune disease that affects over 2.5 million people globally. SSc results in dysfunctional connective tissues with…”
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Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway by Kennerdell, Jason R, Carthew, Richard W

“…We investigated the potential of double-stranded RNA to interfere with the function of genes in Drosophila. Injection of dsRNA into embryos resulted in potent…”
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Heritable gene silencing in Drosophila using double-stranded RNA by Carthew, Richard W, Kennerdell, Jason R

“…RNA-mediated interference (RNAi) is a recently discovered method to determine gene function in a number of organisms, including plants, nematodes, Drosophila,…”
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Abstract 6070: Identification of a molecular glue degrader that engages a cancer-specific E3 ligase by Liu, Yuan, Larsen, Mads, Lin, Bo, Cardenal, Irene A., Kennerdell, Jason R., Finkel, Toren, Chen, Bill B.

“…To date, most successful molecular glues have leveraged ubiquitously expressed E3 ligases, most notably Cereblon in the case of the thalidomide derivatives…”
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Abstract 1619: Generation of a novel estrogen receptor degrader by Liu, Yuan, Kennerdell, Jason R., Lin, Bo, Larsen, Mads B., Alfaras, Irene, Camarco, Daniel P., Tuncer, Ferhan, Finkel, Toren, Chen, Bill B.

“…Fulvestrant is an effective therapy to treat post-menopausal women with estrogen receptor (ER)-positive metastatic breast cancer. The compound works as a…”
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Abstract 1620: Identification of a molecular degrader targeting the AR-V7 splice variant by Liu, Yuan, Lin, Bo, Larsen, Mads B., Alfaras, Irene, Kennerdell, Jason R., Camarco, Daniel P., Tuncer, Ferhan, Finkel, Toren, Chen, Bill B.

“…Prostate cancer is the most common cancer in males and the fifth leading cause of cancer mortality worldwide. A variety of therapeutic approaches exist…”
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Abstract 1805: Identification of a small molecule that induces targeted protein degradation of ADAR1 by Liu, Yuan, Larsen, Mads B., Lin, Bo, Kennerdell, Jason R., Alfaras, Irene, Camarco, Daniel P., Tuncer, Ferhan, Finkel, Toren, Chen, Bill B.

“…Adenosine deaminase acting on RNA (ADAR) are a family of enzymes that catalyzes the posttranscriptional conversion of adenosine to inosine in double-stranded…”
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Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis by Lear, Travis B, Lockwood, Karina C, Larsen, Mads, Tuncer, Ferhan, Kennerdell, Jason R, Morse, Christina, Valenzi, Eleanor, Tabib, Tracy, Jurczak, Michael J, Kass, Daniel J, Evankovich, John W, Finkel, Toren, Lafyatis, Robert, Liu, Yuan, Chen, Bill B

“…Systemic scleroderma (SSc) is an autoimmune disease that affects over 2.5 million people globally. SSc results in dysfunctional connective tissues with…”
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Genetic and cellular analysis of nerve ring defects in Caenorhabditis elegans by Kennerdell, Jason R

“…The nervous system has an exceptionally complex morphology. Even in C. elegans, a relatively simple animal, its complexity and intricacy is impressive. Studies…”
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Genetic and cellular analysis of nerve ring defects in Caenorhabditis elegans by Kennerdell, Jason R

“…The nervous system has an exceptionally complex morphology. Even in C. elegans, a relatively simple animal, its complexity and intricacy is impressive. Studies…”
Get full text