Search Results - "Kennel, Kilian B"

Immune cell - produced ROS and their impact on tumor growth and metastasis by Kennel, Kilian B., Greten, Florian R.

“…Reactive oxygen species (ROS) are derivatives of molecular oxygen (O2) involved in various physiological and pathological processes. In immune cells, ROS are…”
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Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer by Nicolas, Adele M., Pesic, Marina, Engel, Esther, Ziegler, Paul K., Diefenhardt, Markus, Kennel, Kilian B., Buettner, Florian, Conche, Claire, Petrocelli, Valentina, Elwakeel, Eiman, Weigert, Andreas, Zinoveva, Anna, Fleischmann, Maximilian, Häupl, Björn, Karakütük, Cem, Bohnenberger, Hanibal, Mosa, Mohammed H., Kaderali, Lars, Gaedcke, Jochen, Ghadimi, Michael, Rödel, Franz, Arkan, Melek C., Oellerich, Thomas, Rödel, Claus, Fokas, Emmanouil, Greten, Florian R.

“…Standard cancer therapy targets tumor cells without considering possible damage on the tumor microenvironment that could impair therapy response. In rectal…”
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The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer by Kennel, Kilian B, Burmeister, Julius, Radhakrishnan, Praveen, Giese, Nathalia A, Giese, Thomas, Salfenmoser, Martin, Gebhardt, Jasper M, Strowitzki, Moritz J, Taylor, Cormac T, Wielockx, Ben, Schneider, Martin, Harnoss, Jonathan M

“…Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel disease (IBD). HIF-prolyl hydroxylases (PHD1, PHD2, and PHD3) control…”
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Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity by Kennel, Kilian B, Bozlar, Müge, De Valk, Adalbert F, Greten, Florian R

“…Tumor-associated inflammation (TAI) is a feature of essentially all cancers and can confer both tumor-promoting and -suppressive functions. Cancer-associated…”
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Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade by Conche, Claire, Finkelmeier, Fabian, Pešić, Marina, Nicolas, Adele M, Böttger, Tim W, Kennel, Kilian B, Denk, Dominic, Ceteci, Fatih, Mohs, Kathleen, Engel, Esther, Canli, Özge, Dabiri, Yasamin, Peiffer, Kai-Henrik, Zeuzem, Stefan, Salinas, Gabriela, Longerich, Thomas, Yang, Huan, Greten, Florian R

“…Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Glutathione peroxidase 4…”
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The PHD1 oxygen sensor in health and disease by Kennel, Kilian B., Burmeister, Julius, Schneider, Martin, Taylor, Cormac T.

“…The hypoxia‐inducible factor (HIF) co‐ordinates the adaptive transcriptional response to hypoxia in metazoan cells. The hypoxic sensitivity of HIF is conferred…”
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Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation by Schmitt, Mark, Ceteci, Fatih, Gupta, Jalaj, Pesic, Marina, Böttger, Tim W., Nicolas, Adele M., Kennel, Kilian B., Engel, Esther, Schewe, Matthias, Callak Kirisözü, Asude, Petrocelli, Valentina, Dabiri, Yasamin, Varga, Julia, Ramakrishnan, Mallika, Karimova, Madina, Ablasser, Andrea, Sato, Toshiro, Arkan, Melek C., de Sauvage, Frederic J., Greten, Florian R.

“…Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth 1 , 2 . Increasing evidence…”
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Prolyl Hydroxylase Inhibition Mitigates Pouchitis by Harnoss, Jonathan M, Gebhardt, Jasper M, Radhakrishnan, Praveen, Leowardi, Christine, Burmeister, Julius, Halligan, Doug N, Yuan, Shuai, Kennel, Kilian B, Strowitzki, Moritz J, Schaible, Anja, Lasitschka, Felix, Taylor, Cormac T, Schneider, Martin

“…We demonstrate that PHD1 is overexpressed in pouchitis in patients with ulcerative colitis and correlates with disease activity. PHD small-molecule inhibition…”
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