Search Results - "Kennedy, Ryan C."

Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-to-in vivo predictions of hepatic clearance by Krishnan, Preethi, Smith, Andrew K, Ropella, Glen E. P, Dutta, Lopamudra, Kennedy, Ryan C, Hunt, C. Anthony

“…Predictions of xenobiotic hepatic clearance in humans using in vitro-to-in vivo extrapolation methods are frequently inaccurate and problematic. Multiple…”
Get full text

Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms by Smith, Andrew K, Ropella, Glen E P, McGill, Mitchell R, Krishnan, Preethi, Dutta, Lopamudra, Kennedy, Ryan C, Jaeschke, Hartmut, Hunt, C Anthony

“…Interpretations of elevated blood levels of alanine aminotransferase (ALT) for drug-induced liver injury often assume that the biomarker is released passively…”
Get full text

Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments by Smith, Andrew K, Petersen, Brenden K, Ropella, Glen E P, Kennedy, Ryan C, Kaplowitz, Neil, Ookhtens, Murad, Hunt, C Anthony

“…Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in humans. A precondition for improved strategies to disrupt and/or reverse…”
Get full text

Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange by Kennedy, Ryan C, Smith, Andrew K, Ropella, Glen E P, McGill, Mitchell R, Jaeschke, Hartmut, Hunt, C Anthony

“…Abstract Acetaminophen (APAP)-induced liver injury is clinically significant, and APAP overdose in mice often serves as a model for drug-induced liver injury…”
Get full text

Simulation enabled search for explanatory mechanisms of the fracture healing process by Kennedy, Ryan C, Marmor, Meir, Marcucio, Ralph, Hunt, C Anthony

“…A significant portion of bone fractures fail to heal properly, increasing healthcare costs. Advances in fracture management have slowed because translation…”
Get full text

Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi by Jiang, Xiaofang, Peery, Ashley, Hall, A Brantley, Sharma, Atashi, Chen, Xiao-Guang, Waterhouse, Robert M, Komissarov, Aleksey, Riehle, Michelle M, Shouche, Yogesh, Sharakhova, Maria V, Lawson, Dan, Pakpour, Nazzy, Arensburger, Peter, Davidson, Victoria L M, Eiglmeier, Karin, Emrich, Scott, George, Phillip, Kennedy, Ryan C, Mane, Shrinivasrao P, Maslen, Gareth, Oringanje, Chioma, Qi, Yumin, Settlage, Robert, Tojo, Marta, Tubio, Jose M C, Unger, Maria F, Wang, Bo, Vernick, Kenneth D, Ribeiro, Jose M C, James, Anthony A, Michel, Kristin, Riehle, Michael A, Luckhart, Shirley, Sharakhov, Igor V, Tu, Zhijian

“…Anopheles stephensi is the key vector of malaria throughout the Indian subcontinent and Middle East and an emerging model for molecular and genetic studies of…”
Get full text

An automated homology-based approach for identifying transposable elements by Kennedy, Ryan C, Unger, Maria F, Christley, Scott, Collins, Frank H, Madey, Gregory R

“…Transposable elements (TEs) are mobile sequences found in nearly all eukaryotic genomes. They have the ability to move and replicate within a genome, often…”
Get full text

Combination of bendamustine, lenalidomide, and dexamethasone (BLD) in patients with relapsed or refractory multiple myeloma is feasible and highly effective: results of phase 1/2 open-label, dose escalation study by Lentzsch, Suzanne, O'Sullivan, Amy, Kennedy, Ryan C., Abbas, Mohammad, Dai, Lijun, Pregja, Silvana Lalo, Burt, Steve, Boyiadzis, Michael, Roodman, G. David, Mapara, Markus Y., Agha, Mounzer, Waas, John, Shuai, Yongli, Normolle, Daniel, Zonder, Jeffrey A.

“…This multicenter phase 1/2 trial investigated the combination of bendamustine, lenalidomide, and dexamethasone in repeating 4-week cycles as treatment for…”
Get full text

Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity by Hunt, C. Anthony, Kennedy, Ryan C., Kim, Sean H. J., Ropella, Glen E. P.

“…A crisis continues to brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite…”
Get full text

A cell-centered, agent-based framework that enables flexible environment granularities by Kennedy, Ryan C, Ropella, Glen Ep, Hunt, C Anthony

“…Mechanistic explanations of cell-level phenomena typically adopt an observer perspective. Explanations developed from a cell's perspective may offer new…”
Get full text

VectorBase: a home for invertebrate vectors of human pathogens by Lawson, Daniel, Arensburger, Peter, Atkinson, Peter, Besansky, Nora J, Bruggner, Robert V, Butler, Ryan, Campbell, Kathryn S, Christophides, George K, Christley, Scott, Dialynas, Emmanuel, Emmert, David, Hammond, Martin, Hill, Catherine A, Kennedy, Ryan C

“…VectorBase (http://www.vectorbase.org/) is a web-accessible data repository for information about invertebrate vectors of human pathogens. VectorBase annotates…”
Get full text

VectorBase: a home for invertebrate vectors of human pathogens by Lawson, Daniel, Arensburger, Peter, Atkinson, Peter, Besansky, Nora J., Bruggner, Robert V., Butler, Ryan, Campbell, Kathryn S., Christophides, George K., Christley, Scott, Dialynas, Emmanuel, Emmert, David, Hammond, Martin, Hill, Catherine A., Kennedy, Ryan C., Lobo, Neil F., MacCallum, M. Robert, Madey, Greg, Megy, Karine, Redmond, Seth, Russo, Susan, Severson, David W., Stinson, Eric O., Topalis, Pantelis, Zdobnov, Evgeny M., Birney, Ewan, Gelbart, William M., Kafatos, Fotis C., Louis, Christos, Collins, Frank H.

“…VectorBase () is a web-accessible data repository for information about invertebrate vectors of human pathogens. VectorBase annotates and maintains vector…”
Get full text

test of agent-based models as a tool for predicting patterns of pathogen transmission in complex landscapes by Lane-deGraaf, Kelly E, Kennedy, Ryan C, Arifin, SM Niaz, Madey, Gregory R, Fuentes, Agustin, Hollocher, Hope

“…BACKGROUND: Landscape complexity can mitigate or facilitate host dispersal, influencing patterns of pathogen transmission. Spatial transmission of pathogens…”
Get full text

In vitro–in vivo extrapolation of hepatic clearance: using virtual experiments to identify a plausibly influential source of inaccuracies by Hunt, C. Anthony, Smith, Andrew K., Ropella, Glen E. P., Kennedy, Ryan C.

“…It is understood that entanglement of different methodological and biological factors is responsible for IVIVE uncertainties, but untangling them using wet‐lab…”
Get full text

Contrasting model mechanisms of alanine aminotransferase by Smith, Andrew K, Ropella, Glen E. P, McGill, Mitchell R, Krishnan, Preethi, Dutta, Lopamudra, Kennedy, Ryan C, Jaeschke, Hartmut, Hunt, C. Anthony

Get full text

A Phase I Study of Bendamustine Combined with Lenalidomide and Dexamethasone in Patients with Refractory or Relapsed Multiple Myeloma by Lentzsch, Suzanne, O'Sullivan, Amy, Lalo, Silvana, Kruppa, Carrie, Gardner, Diane, Kennedy, Ryan C, Burt, Steve, Mapara, Markus Y, Redner, Robert, Roodman, David, Volkin, Robert L, Zonder, Jeffrey

“…Abstract 1856 Poster Board I-882 Lenalidomide is an analog of thalidomide that has shown significant clinical activity in patients with relapsed or refractory…”
Get full text

Identification and annotation of transposable elements and agent- and GIS-based modeling of pathogen transmission by Kennedy, Ryan C

“…The work presented here has two primary components: (1) the identification and annotation of transposable elements (TEs) and (2) a spatially-aware agent-based…”
Get full text

Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics by ARENSBURGER, Peter, MEGY, Karine, CAMPBELL, Corey L, CAMPBELL, Kathryn S, CASOLA, Claudio, CASTRO, Marta T, CHANDRAMOULISWARAN, Ishwar, CHAPMAN, Sinéad B, CHRISTLEY, Scott, COSTAS, Javier, EISENSTADT, Eric, FESCHOTTE, Cedric, WATERHOUSE, Robert M, FRASER-LIGGETT, Claire, GUIGO, Roderic, HAAS, Brian, HAMMOND, Martin, HANSSON, Bill S, HEMINGWAY, Janet, HILL, Sharon R, HOWARTH, Clint, IGNELL, Rickard, KENNEDY, Ryan C, ABRUDAN, Jenica, KODIRA, Chinnappa D, LOBO, Neil F, CHUNHONG MAO, MAYHEW, George, MICHEL, Kristin, MORI, Akio, NANNAN LIU, NAVEIRA, Horacio, NENE, Vishvanath, NGUYEN, Nam, AMEDEO, Paolo, PEARSON, Matthew D, PRITHAM, Ellen J, PUIU, Daniela, YUMIN QI, RANSON, Hilary, RIBEIRO, Jose M. C, ROBERSTON, Hugh M, SEVERSON, David W, SHUMWAY, Martin, STANKE, Mario, ANTELO, Beatriz, STRAUSBERG, Robert L, CHENG SUN, SUTTON, Granger, ZHIJIAN TU, TUBIO, Jose Manuel C, UNGER, Maria F, VANLANDINGHAM, Dana L, VILELLA, Albert J, WHITE, Owen, WHITE, Jared R, BARTHOLOMAY, Lyric, BIDWELL, Shelby, CALER, Elisabet, CAMARA, Francisco

Get full text

Identification and annotation of transposable elements and agent- and GIS-based modeling of pathogen transmission by Kennedy, Ryan C

“…The work presented here has two primary components: (1) the identification and annotation of transposable elements (TEs) and (2) a spatially-aware agent-based…”
Get full text

Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi by Jiang, Xiaofang, Peery, Ashley, Hall, A, Sharma, Atashi, Chen, Xiao-Guang, Waterhouse, Robert M, Komissarov, Aleksey, Riehl, Michelle M, Shouche, Yogesh, Sharakhova, Maria V, Lawson, Dan, Pakpour, Nazzy, Arensburger, Peter, Davidson, Victoria L M, Eiglmeier, Karin, Emrich, Scott, George, Phillip, Kennedy, Ryan C, Mane, Shrinivasrao P, Maslen, Gareth, Oringanje, Chioma, Qi, Yumin, Settlage, Robert, Tojo, Marta, Tubio, Jose M C, Unger, Maria F, Wang, Bo, Vernick, Kenneth D, Ribeiro, Jose M C, James, Anthony A, Michel, Kristin, Riehle, Michael A, Luckhart, Shirley, Sharakhov, Igor V, Tu, Zhijian

Get full text